A5021200157- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Child Nutrition and Water Access
- Research on Leishmaniasis Studies
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Trypanosoma species research and implications
- History of Medical Practice
- Parvovirus B19 Infection Studies
- Virus-based gene therapy research
Universidad Nacional de Asunción
2007-2023
Fundação Oswaldo Cruz
2013
Ministério da Saúde
2013
Norovirus is a major cause of acute gastroenteritis worldwide. Over 30 different genotypes, mostly from genogroup I (GI) and II (GII), have been shown to infect humans. Despite three decades genome sequencing, our understanding the role genomic diversification across continents time incomplete. To close spatiotemporal gap information human noroviruses, we conducted large-scale genome-wide analyses that included nearly full-length sequencing 281 archival viruses circulating since 1970s in...
Introducción: La leishmaniasis es una enfermedad endémica en Paraguay y aunque representa alta carga la morbimortalidad, no se cuenta con suficientes publicaciones sobre su epidemiología. Objetivo: Describir las características epidemiológicas entomológicas de tegumentaria visceral registrados el período 2017-2020. Metodología: Estudio descriptivo, retrospectivo, epidemiología los vectores asociados a 2017- 2020. información tomó memorias anuales del SENEPA (2017-2020) boletines...
SARS-CoV-2 variant detection relies on resource-intensive whole-genome sequencing methods. We sought to develop a scalable protocol for and surveillance in Paraguay, pairing rRT-PCR spike mutations with Nanopore sequencing. A total of 201 acute-phase nasopharyngeal samples were included. Samples positive the N2 target tested Spike SNP assay detect associated following variants: alpha (501Y), beta/gamma (417variant/484K/501Y), delta (452R/478K), lambda (452Q/490S). calls confirmed using...
SUMMARY Since their discovery, four species of human bocavirus (HBoV) have been described in patients with respiratory and gastrointestinal diseases. However, a clear causal association between HBoV-1 gastroenteritis has not demonstrated. In this study, we describe the detection quantification stools from children acute non-bacterial using quantitative polymerase chain reaction. genome was detected 10·6% frequent rotavirus norovirus. The median viral load 1·88 × 10 4 genome/ml, lower than...
Noroviruses (NoV) have been shown to be an important cause of morbidity and mortality in children worldwide, only second after Group A rotaviruses (RVA). In Paraguay, acute gastroenteritis (AGE) is the third ≤5 years old.To analyze presence diversity NoV Paraguayan old presenting AGE.Three hundred seventy eight fecal samples, negative for pathogenic bacteria RVA, were collected from admitted as ambulatory hospitalized patients a large private hospital Asuncion, Paraguay 2004 2005. The was...
Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, main vector. Seroprevalence studies of chagasic infection are included as part vector programs; they essential assess impact measures and monitor prevention transmission.To interruption transmission by T. infestans Paraguay evaluating current state rural areas.A survey seroprevalence was carried out a representative sample group Paraguayans aged one five...
Abstract Objectives The objective of the current study was to develop a lower-cost and scalable protocol identify monitor SARS-CoV-2 variants in Paraguay by pairing real-time RT-PCR detection spike mutations with amplicon Sanger sequencing whole-genome Nanopore sequencing. Methods 201 acute-phase nasopharyngeal samples from SARS-CoV-2-positive individuals were tested two rRT-PCRs: 1) N2RP assay confirm RNA (CDC N2 target), 2) Spike SNP detect receptor binding domain. performed probes...
Soon after the declaration of COVID-19 pandemic, Institute for Health Sciences Research (IICS) National University Asunción, Paraguay became a testing laboratory (COVID-Lab) SARS-CoV-2. The COVID-Lab performance was assessed from 1 April 2020 to 12 May 2021. effect pandemic on IICS and how contributed academic research activities institute were also assessed. researchers staff adjusted their work schedules support COVID-Lab. Of 13,082 nasopharyngeal/oropharyngeal swabs processed, 2704...
Las precipitaciones extremas representan uno de los eventos naturales climáticos más importantes y pueden originar inundaciones devastadoras. De junio a agosto del 2014 se registró una las graves en la historia ciudad Asunción. Ocasionó un incremento considerable nivel río Paraguay el desplazamiento 300.000 personas campamentos provisionales. Debido que contacto directo con agua inundación, consumo contaminada congregación afectados refugios provisorios son factores riesgo para enfermedades...