A5001438395- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Insect Pest Control Strategies
- Biochemical and Molecular Research
- Organic Chemistry Cycloaddition Reactions
- Crystallization and Solubility Studies
- Piperaceae Chemical and Biological Studies
- Essential Oils and Antimicrobial Activity
- Enzyme function and inhibition
- X-ray Diffraction in Crystallography
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Cocoa and Sweet Potato Agronomy
- Crystallography and molecular interactions
- Toxin Mechanisms and Immunotoxins
- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemistry and Biological Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Transgenic Plants and Applications
- Natural Compounds in Disease Treatment
- Parasites and Host Interactions
Universidad Nacional de Asunción
2014-2025
Instituto de Medicina Tropical
1998-2018
Universidad de Montevideo
2016
Instituto de Investigaciones en Ciencias de la Salud
1996-2014
Universidad de la República
2006
Institut Pasteur
2004
Universidad de Salamanca
2002
Pontificia Universidad Católica de Chile
2000
Introducción: La leishmaniasis es una enfermedad endémica en Paraguay y aunque representa alta carga la morbimortalidad, no se cuenta con suficientes publicaciones sobre su epidemiología. Objetivo: Describir las características epidemiológicas entomológicas de tegumentaria visceral registrados el período 2017-2020. Metodología: Estudio descriptivo, retrospectivo, epidemiología los vectores asociados a 2017- 2020. información tomó memorias anuales del SENEPA (2017-2020) boletines...
This publication reports the controlled cultivation of Zanthoxylum chiloperone var. angustifolium Engl. (Rutaceae) in several growth substrates under greenhouse conditions. plant is well-known for its anti-Chagas (trypanocidal) activity, related to presence β-carboline alkaloids. The metabolomic study Z. seedlings over two years (2018–2020) was performed using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS). canthin-6-one alkaloids, and...
For a fourth approach of quinoxaline N,N′-dioxides as anti-trypanosomatid agents against T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us to state the correct requirements for obtaining optimal in vitro anti-T. activity. Derivatives possessing electron-withdrawing substituents 2-, 3-, 6-, 7-positions were most compounds. With regard these features taking into account their mammal cytotoxicity, some trifluoromethylquinoxaline have been proposed...
Chagas disease, caused by Trypanosoma cruzi parasite, was described thousands of years ago. Currently, it affects millions people, mostly in Latin America, and there are not suitable drugs for treating it. As an attempt to find appropriate deal with this problem, we report here on the design, synthesis, characterization 82 new compounds. Trypanosomicidal behavior vitro showed more than 20 outstanding derivatives anti-Trypanosoma activity. Furthermore, studied nonspecific toxicity against...
ABSTRACT Although the parasitic infection Chagas' disease was described over 100 years ago, even now there are not suitable drugs. The available drugs nifurtimox and benznidazole have limited efficacies tolerances, with proven mutagenic effects. Attempting to find appropriate deal this problem, here we report on development pharmacological characterization of new amide-containing thiazoles. In present study, evaluated in vitro vivo effects candidates against Trypanosoma cruzi , etiological...
Three series of benzimidazole N-oxide derivatives were developed and examined for their activity against trypanosomatid parasites (Trypanosoma cruzi Leishmania spp.). 2H-Benzimidazole 1,3-dioxides displayed remarkable in vitro activities both parasites, with 28, 29, 32 being the most potent (IC50 < 5 μM) epimastigote form T. 33, 35 promastigote spp. Unspecific cytotoxicity was evaluated using murine macrophages, derivative 33 not toxic at a concentration 30 times that its IC50 completely...
Abstract Triosephosphate isomerase (TIM) is an essential Trypanosoma cruzi enzyme and one of the few validated drug targets for Chagas disease. The known inhibitors this behave poorly or have low activity in parasite. In work, we used symmetrical diarylideneketones derived from structures with trypanosomicidal activity. We obtained enzymatic inhibitor IC 50 value 86 n m without inhibition effects on mammalian enzyme. These molecules also affected cruzipain, another proteolytic This dual...
Two new prenylated quinones, piperogalone (1) and galopiperone (2), a dihydroquinone, hydropiperone (3), were isolated from Peperomia galioides H.B.K (Piperaceae). Hydropiperone exhibited potent antiparasitic activity against three species of Leishmania.
Extracts from the Argentinean herb Tagetes mendocina Phil.(Asteraceae) were tested for antimicrobial activity against fungi, bacteria and protozoa.The different extracts (PE, DCM, MeOH EtOAc) essential oil displayed mainly dermatophytes, a group of fungi that produces skin infections.The bioassay-guided fractionation PE, DCM EtOAc led to isolation eight compounds including two thiophenes, acetophenone derivatives, dihydrorosefuran three flavonoids.The thiophenes 5-(4-hydroxy-1-butynyl)-2,2 '...
The currently available treatments for Chagas disease show limited therapeutic potential and are associated with serious side effects. Attempting to find alternative drugs isolated from Nature as agents against Trypanosoma cruzi has been our goal. Recently, we have demonstrated the in vitro anti-T. activities of two secondary metabolites hydro-ethanolic extract aerial parts Aristeguietia glutinosa (Lam.), (family Asteraceae). These active principles displayed poor hemolytic activity, low...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Aporphine Alkaloids from Guatteria foliosaV. Mahiou, F. Roblot, R. Hocquemiller, A. Cavé, Rojas De Arias, Inchausti, G. Yaluff, Fournet, and AngeloCite this: J. Nat. Prod. 1994, 57, 7, 890–895Publication Date (Print):July 1, 1994Publication History Published online1 July 2004Published inissue 1 1994https://pubs.acs.org/doi/10.1021/np50109a003https://doi.org/10.1021/np50109a003research-articleACS PublicationsRequest reuse permissionsArticle...
Bioactivity-directed fractionation of the MeOH extract stem barks Rollinia emarginata resulted in isolation six compounds, four acetogenins, rolliniastatin-1, sylvaticin, squamocin, and rollidecin B, one lignan, lirioresinol an oxoaporphine, liriodenin. Their structures were determined by spectroscopic analysis their vitro leishmanicidal trypanocidal properties are reported.
Cryptofolione (1) and the new cryptofolione derivative 6-(4,6-dimethoxy-8-phenyl-octa-1,7-dienyl)-4-hydroxy-tetrahydro-pyran-2-one (2) were isolated from fruits of Cryptocarya alba. The structures elucidated by spectroscopic methods. showed activity towards Trypanosoma cruzi trypomastigotes, reducing their number 77% at 250 microg mL(-1). moderate cytotoxicity in both macrophages T. amastigotes. It also displayed a mild inhibitory effect on promastigote form Leishmania spp. As cytotoxic...
A series of quinones (3a-i, 4-9, 11) and aromatic compounds (2a, 2b, 2g) containing the thiophene ring were tested in vitro against trypomastigote form Trypanosoma cruzi promastigote forms Leishmania. The 3a-i, 4, 5a, b, 6 9 having fused to a quinone nucleus most active members series. electron affinities benzo[b]thiophene-4, 7-quinones 3, evaluated by their LUMO energies halfwave potentials, are reported.
Eleven bisbenzylisoquinoline (BBIQ) alkaloids were studied for in vitro trypanocidal activity against trypomastigote forms of the Y strain Trypanosoma cruzi. The inhibitory these compounds trypanothione reductase (TR), a target enzyme chemotherapy Chagas disease, was also studied. Six BBIQ (antioquine, cepharanthine, daphnoline, limacine, cycleanine and (-) curine) displayed 50% lethal concentration (LC50) T. cruzi less than 100μM. Daphnoline curine, with LC50 values 10μM, are attractive...