A5005203865- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
- Research on Leishmaniasis Studies
- Bioactive Compounds and Antitumor Agents
- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Cardiovascular Issues in Pregnancy
- Toxoplasma gondii Research Studies
- Ferrocene Chemistry and Applications
- Insect and Pesticide Research
- Parasites and Host Interactions
- Tannin, Tannase and Anticancer Activities
- Parasitic Infections and Diagnostics
- Malaria Research and Control
- Cancer, Hypoxia, and Metabolism
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Cancer therapeutics and mechanisms
- Molecular Junctions and Nanostructures
- Genomics, phytochemicals, and oxidative stress
- Parasite Biology and Host Interactions
- Vector-Borne Animal Diseases
- Adenosine and Purinergic Signaling
University of Chile
2015-2024
Centro de Investigacion Principe Felipe
2018
Institución Universitaria Esumer
2014
Universidad de la República
2006
Pontificia Universidad Católica de Chile
2005
In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel (II) formulas [PdCl2(HL)] and [Pd(L)2] synthesized, crystal structure of [Pd(5-nitrofuryl-3-acroleine thiosemicarbazone)2]·3DMSO was solved by X-ray diffraction methods. Most showed higher in vitro growth inhibition activity Trypanosoma cruzi than standard drug Nifurtimox. most cases, ligand maintained or...
Tumor cells principally exhibit increased mitochondrial transmembrane potential (ΔΨ(m)) and altered metabolic pathways. The therapeutic targeting delivery of anticancer drugs to the mitochondria might improve treatment efficacy. Gallic acid exhibits a variety biological activities, its ester derivatives can induce dysfunction. Four alkyl gallate triphenylphosphonium lipophilic cations were synthesized, each differing in size linker chain at cationic moiety. These selectively cytotoxic toward...
Based on the observed biological activities of coumarins and chalcones, we have synthesized coumarin–chalcone hybrids with aim evaluating their antioxidant properties trypanocidal activity against Trypanosoma cruzi, parasite responsible for Chagas disease. All derivatives been proved to be good antioxidants in spite moderate epimastigote stage (clone Dm28c). these results, can conclude that compounds 4 5 are potential candidates vitro studies activity. These preliminary findings encourage us...
Chagas disease is a health threat for many people, mostly those living in Latin America. One of the most important problems treatment limitation existing drugs. Prodigiosin, produced by Serratia marcescens (Rhodnius prolixus endosymbiont), belongs to red-pigmented bacterial prodiginine family, which displays numerous biological activities, including antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties. Here we describe its effects on...
l-Buthionine (S,R)-sulfoximine (BSO) increased the toxicity of nifurtimox and benznidazole toward epimastigote, trypomastigote, amastigote forms Trypanosoma cruzi. BSO at 500 muM decreased total glutathione-derived thiols by 70 to 80% in 48 h. In epimastigotes, concentration needed inhibit constant growth parasites 50%, from 14.0 9.0 muM, that 43.6 24.1 muM. The survival epimastigotes or trypomastigotes treated with benznidazole, as measured MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl...
Chagas' disease, produced by Trypanosoma cruzi, affects more than 8 million people, producing approximately 10,000 deaths each year in Latin America. Migration of people from endemic regions to developed countries has expanded the risk infection, transforming this disease into a globally emerging problem. PGE2 and other eicosanoids contribute cardiac functional deficits after infection with T. cruzi. Thus, inhibition host cyclooxygenase (COX) enzyme emerges as potential therapeutic target....