A5014195930- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Cardiovascular Issues in Pregnancy
- Toxoplasma gondii Research Studies
- Pregnancy and preeclampsia studies
- Biochemical and Molecular Research
- Metal complexes synthesis and properties
- Parasitic Infections and Diagnostics
- Bioactive Compounds and Antitumor Agents
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Salivary Gland Disorders and Functions
- Reproductive System and Pregnancy
- Cardiomyopathy and Myosin Studies
- Preterm Birth and Chorioamnionitis
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Signaling Pathways in Disease
- Glycosylation and Glycoproteins Research
- Tannin, Tannase and Anticancer Activities
University of Chile
2016-2025
Instituto de Neurociencia Biomédica
2019
National University of La Rioja
2012
University of Talca
2003-2011
Tumor cells principally exhibit increased mitochondrial transmembrane potential (ΔΨ(m)) and altered metabolic pathways. The therapeutic targeting delivery of anticancer drugs to the mitochondria might improve treatment efficacy. Gallic acid exhibits a variety biological activities, its ester derivatives can induce dysfunction. Four alkyl gallate triphenylphosphonium lipophilic cations were synthesized, each differing in size linker chain at cationic moiety. These selectively cytotoxic toward...
Breast cancer is the most prevalent type of among women worldwide and it characterized by a high morbidity. Curcumin naturally occurring compound derived from rhizome Curcuma longa known to have antioxidant anticarcinogenic properties. Emerging evidence has indicated that microRNAs (miRNAs or miRs) function as oncogenes tumor suppressor genes control invasion migration. The aim this study was evaluate effects curcumin on implicated in epithelial‑mesenchymal transition (EMT) examine...
Chagas' disease, produced by Trypanosoma cruzi, affects more than 8 million people, producing approximately 10,000 deaths each year in Latin America. Migration of people from endemic regions to developed countries has expanded the risk infection, transforming this disease into a globally emerging problem. PGE2 and other eicosanoids contribute cardiac functional deficits after infection with T. cruzi. Thus, inhibition host cyclooxygenase (COX) enzyme emerges as potential therapeutic target....
Problem Trypanosoma cruzi and Toxoplasma gondii present, respectively, low high congenital transmission rates. The placenta as an immune regulatory organ expresses TLR s, leading to the secretion of cytokines. Both parasites are recognized by ‐2, ‐4, ‐9. Here, we studied if induce differences in protein expression, cytokine profiles, whether receptor inhibition is related parasite infection. Method study Placental tissue explants were infected ex vivo with each parasite, s profile infection...
Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin America. Most infections occur in children vector or congenital transmission. cruzi establishes complexity of specific molecular parasite-host cell interactions invade the host. However, most studies have been mainly focused on interaction between and different types, but not infection invasion tissue level. During transmission, T. must cross placental barrier, composed epithelial connective tissues, order infect...
The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described natural compound, 10-((2,5-dihydroxybenzoyl)oxy)decyl) triphenylphosphonium bromide (GA-TPP+C10), with hydroquinone scaffold that selectively targets the mitochondria breast (BC) cells by binding group chemical chaperone; however, mechanism action remains unclear. In this work, showed GA-TPP+C10...