A5078691963- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Oxidative Organic Chemistry Reactions
- Synthesis and Reactions of Organic Compounds
- melanin and skin pigmentation
- Medicinal Plants and Neuroprotection
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Chemical synthesis and alkaloids
- Catalytic Cross-Coupling Reactions
- Bioactive Compounds and Antitumor Agents
- Nitric Oxide and Endothelin Effects
- Plant chemical constituents analysis
- Multicomponent Synthesis of Heterocycles
- Cholinesterase and Neurodegenerative Diseases
- Ferrocene Chemistry and Applications
- Pharmacological Receptor Mechanisms and Effects
- Chemotherapy-induced cardiotoxicity and mitigation
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Education during COVID-19 pandemic
- Parkinson's Disease Mechanisms and Treatments
- Nanoparticle-Based Drug Delivery
- Urban Development and Societal Issues
- Trypanosoma species research and implications
Azienda Sanitaria Unità Locale di Reggio Emilia
2023-2024
Institut de Chimie Moléculaire et des Matériaux d'Orsay
2018-2019
Université Paris-Saclay
2018
Université Paris-Sud
2018
Centre Hospitalier d'Orsay
2018
University of Namur
2013-2016
Namur Research Institute for Life Sciences
2013-2015
Universidade de Santiago de Compostela
2009-2015
Pharmac
2014
University of Cagliari
2010-2014
Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. Several 3-arylcoumarin derivatives were previously described as interesting selective MAO-B inhibitors. Preserving trans-stilbene structure, a series 2-arylbenzofuran and corresponding synthesized evaluated inhibitors both MAO isoforms, MAO-A MAO-B. In general, types found to be inhibitors, with IC50 values in nano- micromolar range. 5-Nitro-2-(4-methoxyphenyl)benzofuran (8) most active compound...
Abstract Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Both isoforms, MAO‐A MAO‐B, are known to play critical roles disease progression, as such, identification novel, potent selective inhibitors an important research goal. Here, two series 3‐phenylcoumarin derivatives were synthesized evaluated against MAO‐B. Most compounds tested acted preferentially on with IC 50 values micromolar nanomolar range. Only...
Abstract Objectives We report the pharmacological evaluation of a new series 3-aminocoumarins differently substituted with hydroxyl groups, which have been synthesized because they include in their structures tyrosine fragment (tyrosine-like compounds), aim discovering structural features necessary for tyrosinase inhibitory activity. Methods The compounds 4 and 7–9 were evaluated vitro as mushroom inhibitors. Key findings Two described showed lower IC50 (concentration giving 50% inhibition...
Spatiotemporally controlled dual delivery: a small molecular timer was designed to release two chemicals at programmed intervals, which could be tuned in wide range.
Due to the potential antibacterial activity of chalcone and coumarin moieties, hybrid compounds containing both structures have been synthesized in good yield using Knoevenagel reaction as key step.
Abstract BACKGROUND Seizures occur in up to 60% of patients with glioblastoma (GBM), revealing the tumor 25-30% cases. The understanding biology associated epilepsy as presenting symptom remains limited. Moreover, despite growing preclinical evidence a link between epileptogenesis and tumorigenesis, prognostic role seizures at onset debated, partly due study heterogeneity. MATERIAL AND METHODS We leveraged homogeneous cohort WHO 2021 GBM from our Institution available clinical, molecular,...
Pituitary metastases are very rare in cancer patients and often originate from lung or breast tumors. They usually occur with known metastatic disease, but rarely may be the first presentation of primary tumor.We present case a 58 years-old-man who reported three-month history polyuria-polydipsia syndrome, generalized asthenia, panhypopituitarism bitemporal hemianopsia. Brain-MRI showed voluminous pituitary mass causing posterior sellar enlargement compression surrounding structures...
Cancer is at present one of the most leading causes death in developed countries, and many efforts have been made to discover agents endowed with cytotoxic action. Natural products, their ability interact more than target, represent medicinal chemistry a significant source inspiration for design structural analogues an improved pharmacological profile. Coumarins are important family natural synthetic origin that has attracting intense interest recent years remarkable array biological...
Bacterial diseases of freshwater fish epithelia have been extensively studied; however in marine fishes relatively few bacterial skin and gill characterized. Tenacibaculum maritimum, a Gram-negative filamentous bacterium, has described as the etiological agent tenacibaculosis fish. Since 1990, farming became steadily growing industry, this disease widely distributed several countries is considered limiting factor for culture many species commercial value world. Among drugs used past years...