A5073737324- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Birth, Development, and Health
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neuropharmacology Research
- Prenatal Substance Exposure Effects
- Neuroendocrine regulation and behavior
- PARP inhibition in cancer therapy
- Child Abuse and Trauma
- Identity, Memory, and Therapy
- RNA Research and Splicing
- RNA regulation and disease
- Ion channel regulation and function
- RNA Interference and Gene Delivery
- Neurotransmitter Receptor Influence on Behavior
- Gut microbiota and health
- Receptor Mechanisms and Signaling
- Hormonal and reproductive studies
Bar-Ilan University
2013-2023
Douglas Mental Health University Institute
2023
Previous studies in animal models of cocaine craving have delineated broad changes DNA methylation profiles the nucleus accumbens. A crucial factor for progress behavioral and mental health epigenetics is discovery epigenetic markers peripheral tissues. Several primates humans associated differences phenotypes with T cells brain. Herein, we present a pilot study (n = 27) showing that cell profile differentiates persons substance use disorder from controls. Intervention dehydroepiandrosterone...
Abstract Post-traumatic-stress-disorder (PTSD) is a stress-related condition that may develop after exposure to severe trauma-event. One of the core brain areas considered be key regulatory region PTSD amygdala. Specifically, central amygdala (CeA) involved in emotion processing and associative fear learning memory, two main circuits PTSD. Long term dysregulation trauma-related emotional caused by neuroadaptations affect gene expression. The adenosine-(A) to-inosine (I) RNA editing machinery...
Substance use disorders (SUDs) are associated with depression and anxiety, the latter being one of major factors in substance-seeking relapse. Due to dose-dependent sedative side effects there is limited efficacy baclofen treatment for SUDs. Here we suggest a novel combination opipramol (O/B) which known attenuate anxiety depression, facilitation recovery from Since both have common downstream signal transduction, their individual doses could be reduced while still maintaining benefits...
Ras-related C3 botulinum toxin substrate 1 (Rac1), of the Rho small GTPase family, is a key regulator actin cytoskeleton rearrangement and plays an important role in dendritic morphogenesis. Cocaine produces neuronal alterations, including structural changes number morphology. Emerging data indicate sigma-1 receptors (σ-1Rs) as promising candidate for prevention cocaine craving. Opipramol σ-1R agonist approved some European countries depression anxiety. Here we report that opipramol,...