A5079084404- Mitochondrial Function and Pathology
- Neurological diseases and metabolism
- interferon and immune responses
- Herpesvirus Infections and Treatments
- Nerve injury and regeneration
- Axon Guidance and Neuronal Signaling
- Cell death mechanisms and regulation
- Metabolism and Genetic Disorders
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Neuroscience and Neuropharmacology Research
- Inflammasome and immune disorders
- Genetic Neurodegenerative Diseases
- Biochemical effects in animals
- Protein Kinase Regulation and GTPase Signaling
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
- Toxin Mechanisms and Immunotoxins
University of North Carolina at Chapel Hill
2015-2025
Abstract Axon pruning is a unique process neurons utilize to selectively degenerate axon branches while keeping the neuronal cell body intact. The mechanisms of have much in common with those apoptosis. Both and apoptosis pathways require key apoptotic proteins (Bax, Caspase-9, Caspase-3). Interestingly, does not Apaf-1, member apoptosome complex. As such, exactly how caspases are activated an apoptosome-independent manner during unknown. Here we show that NLRP1 inflammasome, innate immune...
Abstract While the consequences of nuclear DNA damage have been well studied, exact acute and selective mitochondrial (mtDNA) are less understood. damaging chemotherapeutic drugs known to activate p53-dependent apoptosis in response sustained damage. it is recognized that whole-cell exposure these also damages mtDNA, specific contribution mtDNA cellular degeneration clear. To examine this, we induced neuronal axons using microfluidic chambers allow for spatial fluidic isolation cell bodies...