A5039996453- Immune Response and Inflammation
- Barrier Structure and Function Studies
- Nuclear Issues and Defense
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Molecular Biology Techniques and Applications
- Inflammasome and immune disorders
- Immune cells in cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
University of North Carolina at Chapel Hill
2023-2025
National Institute of Environmental Health Sciences
2023
Abstract Axon pruning is a unique process neurons utilize to selectively degenerate axon branches while keeping the neuronal cell body intact. The mechanisms of have much in common with those apoptosis. Both and apoptosis pathways require key apoptotic proteins (Bax, Caspase-9, Caspase-3). Interestingly, does not Apaf-1, member apoptosome complex. As such, exactly how caspases are activated an apoptosome-independent manner during unknown. Here we show that NLRP1 inflammasome, innate immune...
Abstract Microglia function as the tissue‐specific resident macrophages of nervous system, performing immune and non‐immune functions. These functions are critical to development maintain homeostasis in system throughout lifespan, during brain injury or disease. One method by which microglia is phagocytosis aberrant proteins, extracellular debris, synapses, apoptotic cells. Phagocytic can be changed environmental genetic risk factors that affect microglia. protocols present a rapid simple...
This case study was designed to help students explore the molecular mechanisms of spliceosome and how SARS-CoV-2 impacts host cell spliceosomal function while interpreting figures from primary literature (A. K. Banjeree, et al., Cell 183:1325-1339, e1-e10, 2020, https://doi.org/10.1016/j.cell.2020.10.004). "Pete Missing Scissors" implemented in spring 2022 fall two large-enrollment (150+) introductory biology courses at a large, public research institution. The formatted alignment with...