A5101578920- Diffusion and Search Dynamics
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Spectroscopy and Quantum Chemical Studies
- Protein Structure and Dynamics
- Viral Infections and Immunology Research
- Lipid Membrane Structure and Behavior
- Advanced Thermodynamics and Statistical Mechanics
- Vector-borne infectious diseases
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Nuclear Structure and Function
- stochastic dynamics and bifurcation
- Material Dynamics and Properties
- Probabilistic and Robust Engineering Design
- Virus-based gene therapy research
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- Nanopore and Nanochannel Transport Studies
- Viral Infections and Vectors
- Microbial Metabolic Engineering and Bioproduction
- Force Microscopy Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- RNA and protein synthesis mechanisms
- Proteins in Food Systems
University of Engineering & Management
2024
Indian Institute of Technology Palakkad
2020-2024
Center for Theoretical Biological Physics
2014
New York Medical College
2013
Wadsworth Center
2013
University of California, Irvine
2013
New York State Department of Health
2013
Indian Institute of Science Bangalore
2008-2011
National Institute of Cholera and Enteric Diseases
2009-2010
Powassan virus, a member of the tick-borne encephalitis group flaviviruses, encompasses 2 lineages with separate enzootic cycles. The prototype lineage virus (POWV) is principally maintained between Ixodes cookei ticks and groundhog (Marmota momax) or striped skunk (Mephitis mephitis), whereas deer tick (DTV) believed to be scapularis white-footed mouse (Peromyscus leucopus). We report 14 cases from New York during 2004-2012. Ten (72%) patients were residents Lower Hudson Valley, Lyme...
SUMMARY Faecal specimens of diarrhoea cases ( n =2495, collected between November 2007 and October 2009) from Infectious Diseases Beliaghata General (ID&BG) Hospital, Kolkata, India, were screened by RT–PCR using specific primers targeting region C the capsid gene noroviruses (NoVs) to determine seasonal distribution clinical characteristics NoVs associated with diarrhoea. NoV infection was detected in 78 cases, mostly children aged <2 years. In 22/78 positive virus as sole agent;...
The utility of an approximate heuristic version Kramers’ theory reaction rates that was earlier used [Chaudhury and Cherayil, J. Chem. Phys. 125, 024904 (2006)] to successfully describe the nonexponential waiting time distributions enzyme β-galactosidase is reassessed. original model, based on Smoluchowski equation, reformulated in terms phase space variables coordinate, without neglecting inertial contributions. A new derivation Fokker–Planck equation (FPE) describes dynamics this...
Static disorder has recently been implicated in the non-exponential kinetics of unfolding single molecules poly-ubiquitin under a constant force [Kuo, Garcia-Manyes, Li, Barel, Lu, Berne, Urbakh, Klafter, and Fernández, Proc. Natl. Acad. Sci. U.S.A. 107, 11336 (2010)]. In present paper, it is suggested that dynamic may provide plausible, alternative description experimental observations. This suggestion made on basis model which barrier to chain assumed be modulated by control parameter r...
Many fundamental biophysical processes involving gene regulation and editing rely, at the molecular level, on an intricate methodology of searching locating precise target base pair sequence genome by specific binding proteins. A unique mechanism, known as 'facilitated diffusion', which is a combination 1D sliding along with 3D movement, considered to be key step for such events. This also explains relatively much shorter timescale process, compared other diffusion-controlled processes. In...
Multispecies biofilms are complex communities of microbial cells, and their medicinal ecological significance quite difficult to understand since they mostly have high antimicrobial resistance compared mono-species biofilms. The therapeutic strategies for pathogenic microorganisms became complicated due the morphogenic shift from a planktonic biofilm phenotype, resistant antibiotics, dehydration, biocides, UV radiation, host immunological reactions. condition is further aggravated with...
We show that data from recent experiments carried out on the kinetics of DNA escape α-hemolysin nanopores [M. Wiggin, C. Tropini, T. Cossa, N. Jetha, and A. Marziali, Biophys. J. 95, 5317 (2008)] may be rationalized by a model chain dynamics based anomalous diffusion particle moving in harmonic well presence delta function sink. The Wiggin et al. found, among other things, occasional occurrence unusually long times distribution trapping events led to nonexponential decays survival...
Cargo transport through the nuclear pore complex continues to be a subject of considerable interest experimentalists and theorists alike. Several recent studies have revealed details process that still fully understood, among them apparent nonlinearity between cargo size crossing time, skewed, asymmetric nature distribution such times, non-exponentiality in decay profile dynamic autocorrelation function positions. In this paper, we show model based on subdiffusive particle motion is...
A recent theoretical model developed by Imparato [Phys. Rev. E 76, 050101(R) (2007)] of the experimentally measured heat and work effects produced thermal fluctuations single micron-sized polystyrene beads in stationary moving optical traps has proved to be quite successful rationalizing observed experimental data. The model, based on overdamped Brownian dynamics a particle harmonic potential that moves at constant speed under time-dependent force, is used obtain an approximate expression...
The functional application of RNA-guided CRISPR-associated Cas9 protein, a bacterial immune system-based protein complex, via which in vivo, highly specific, and well-regulated, gene-editing processes are being monitored at an unprecedented level, has led to remarkable progress genetic engineering technology. complicated vivo process genome interrogation followed by gene editing the complex was recently reported Knight et al. (Science, 2015, 350, 823–826) using elegant single-particle...
We show that a model of target location involving n noninteracting particles moving subdiffusively along line segment (a generalization introduced by Sokolov et al. [Biophys. J. 2005, 89, 895.]) provides basis for understanding recent experiments Pelta [Phys. Rev. Lett. 2007, 98, 228302.] on the kinetics diffusion-limited gel degradation. These find time t(c) taken enzyme thermolysin to completely hydrolyze varies inversely as roughly 3/2 power initial concentration [E]. In general, however,...