A5019745268- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- RNA modifications and cancer
- CAR-T cell therapy research
- Mesenchymal stem cell research
- Cytomegalovirus and herpesvirus research
- Cancer, Hypoxia, and Metabolism
- Insurance and Financial Risk Management
- Connective Tissue Growth Factor Research
- Histone Deacetylase Inhibitors Research
- Financial Distress and Bankruptcy Prediction
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Congenital Anomalies and Fetal Surgery
- Neuroethics, Human Enhancement, Biomedical Innovations
- Immune cells in cancer
- interferon and immune responses
- Viral-associated cancers and disorders
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
McGill University
2019-2024
McGill Genome Centre
2021-2024
University of British Columbia
2022
Czech Academy of Sciences, Institute of Physiology
2020
Abstract As metagenomic approaches for detecting infectious agents have improved, each tissue that was once thought to be sterile has been found harbor a variety of microorganisms. Controversy still exists over the status amniotic fluid, which is part an immunologically privileged zone required prevent maternal immune system rejection fetus. Due this privilege, exclusion microbes proposed mandatory, leading womb hypothesis. Since nucleic acid yields from fluid are very low, contaminating in...
Abstract Stem and progenitor cells are the main mediators of tissue renewal repair, both under homeostatic conditions in response to physiological stress injury. Hematopoietic system is responsible for regeneration blood immune maintained by bone marrow-resident hematopoietic stem (HSPCs). particularly susceptible injury genotoxic stress, resulting risk marrow failure secondary malignancies cancer patients undergoing radiotherapy. Here we analyze vivo transcriptional HSPCs a mouse whole-body...
Ribosomopathies are congenital disorders caused by mutations in the genes encoding ribosomal and other functionally related proteins. They characterized anemia, hematopoietic developmental abnormalities, p53 activation. Ribosome assembly requires coordinated expression of many protein (RP) genes; however, regulation RP gene expression, especially stem cells (HSCs), remains poorly understood. MYSM1 is a transcriptional regulator essential for HSC function hematopoiesis. We established that...
BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, via deubiquitination histone H2AK119ub substrates. an important tumor suppressor in human, expressed functional across many cell-types tissues, including those immune system. B lymphocytes are mediators humoral response, however role cell development physiology remains poorly understood. Here we characterize mouse line with selective deletion within...
Myb-like SWIRM and MPN domains 1 (MYSM1) is a chromatin binding protein with deubiquitinase (DUB) catalytic activity. Rare MYSM1 mutations in human patients result an inherited bone marrow failure syndrome, highlighting the biomedical significance of hematopoietic system. We others characterized Mysm1-knockout mice as model this disorder established that regulates function leukocyte development such models through different mechanisms. It is, however, unknown whether DUB activity universally...
Abstract MYSM1 is a chromatin‐binding protein, widely investigated for its functions in haematopoiesis human and mouse; however, role haematologic malignancies remains unexplored. Here, we investigate the cross‐talk between oncogenic cMYC transcriptional regulation of genes encoding ribosomal proteins, implications these mechanisms cMYC‐driven carcinogenesis. We demonstrate that B cell lymphoma mouse models, MYSM1‐loss represses protein gene expression synthesis. Importantly, loss also...
Dendritic cells (DCs) are the most significant antigen presenting of immune system, critical for activation naïve T cells. The pathways controlling DC development, maturation, and effector function therefore require precise regulation to allow an effective induction adaptive response. MYSM1 is a chromatin binding deubiquitinase (DUB) activator gene expression via its catalytic activity monoubiquitinated histone H2A (H2A-K119ub), which highly abundant repressive epigenetic mark. important...
Rocaglates are a class of eukaryotic translation initiation inhibitors that being explored as chemotherapeutic agents. They function by targeting factor (eIF) 4A, an RNA helicase critical for recruitment the 40S ribosome (and associated factors) to mRNA templates. perturb eIF4A activity imparting gain-of-function and mediating clamping RNA. To appreciate how rocaglates could best be enabled in clinic, understanding resistance mechanisms is important, this inform on strategies bypass such...
Introduction BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, through its direct catalytic activity on repressive epigenetic mark histone H2AK119ub, as well several substrates. also highly important tumor suppressor, expressed functional across many cell types tissues. In recent work, we demonstrated intrinsic role in B lineage development murine bone marrow, however regulation mediated humoral...
Summary CD4 + T cells have a remarkable potential to differentiate into diverse effector lineages following activation. Here, we probed the heterogeneity present among naïve before encountering their cognate antigen ask whether is modulated by pre-existing transcriptional and epigenetic differences. Using single-cell RNA sequencing, showed that key drivers of variability are genes involved in cell receptor (TCR) signaling. CD5 expression as read-out strength tonic TCR interactions with...
Abstract The global financial crisis that has erupted many times in recent years not only harmed the systems of various countries, but even severely hit economies countries. Therefore, importance risk early warning become more prominent and challenges facing it have severe. In view this, is very important to explore an extreme model suits reality Chinese market, accurately predict prevent risks. This article first constructs model’s early-warning indicator system, determines state indicators...