A5018637533- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Johannes Gutenberg University Mainz
2022-2023
University Medical Center of the Johannes Gutenberg University Mainz
2023
Abstract Obesity promotes endothelial dysfunction. Endothelial cells not only respond, but possibly actively promote the development of obesity and metabolic Our aim was to characterize role leptin receptors (LepR) for whole body metabolism diet-induced obesity. Mice with tamoxifen-inducible, Tie2.Cre-ER T2 -mediated deletion LepR in (End.LepR knockout, KO) were fed high-fat diet (HFD) 16 weeks. Body weight gain, serum levels, visceral adiposity adipose tissue inflammation more pronounced...
Erythrocytes (red blood cells) participate in the control of vascular NO bioavailability. The purpose this study was to determine whether and how genetic deletion ARG1 (arginase-1) affects smooth muscle cell signaling, osteoblastic differentiation, atherosclerotic lesion calcification.Atherosclerosis-prone mice with conditional, erythrocyte-restricted (apoE-/- red cell.ARG1 knockout) were generated calcification studied using molecular imaging osteogenic activity agent OsteoSense, Alizarin...