A5051053583- Hematopoietic Stem Cell Transplantation
- Single-cell and spatial transcriptomics
- Pluripotent Stem Cells Research
Massachusetts Institute of Technology
2020-2021
Howard Hughes Medical Institute
2020
Small cell size preserves the function of hematopoietic stem cells (HSCs); HSC enlargement during aging causes their dysfunction.
Abstract Stem cells are remarkably small in size. Whether size is important for stem cell function unknown. We find that murine hematopoietic (HSCs) enlarge under conditions known to decrease function. This decreased fitness of large HSCs due reduced proliferative potential. Preventing HSC enlargement by inhibiting macromolecule biosynthesis or reducing shortening G 1 averts the loss potential causing exhaustion. Finally, we show a fraction and human during aging. this age-dependent improves...