A5053477945- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Birth, Development, and Health
- Tissue Engineering and Regenerative Medicine
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Selenium in Biological Systems
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Endometrial and Cervical Cancer Treatments
Instituto de Investigación Sanitaria La Fe
2020-2024
Valencian Infertility Institute
2020
The diagnosis of endometriosis by laparoscopy is delayed until advanced stages. In recent years, microRNAs have emerged as novel biomarkers for different diseases. These molecules are small non-coding RNA sequences involved in the regulation gene expression and can be detected peripheral blood. Our aim was to identify candidate serum associated with their role minimally invasive biomarkers. Serum samples were obtained from 159 women, whom 77 diagnosed 82 healthy women. First, a preliminary...
Ovarian aging is the main cause of infertility and telomere attrition common to both fertility disorders. Senescence-Accelerated Mouse Prone 8 (SAMP8) model has shortened lifespan premature infertility, reflecting signs reproductive senescence described in middle-aged women. Thus, our objective was study SAMP8 female pathway at point senescence. The control mice monitored. Telomere length (TL) measured by situ hybridization blood ovary. Telomerase activity (TA) analyzed telomere-repeat...
Most women who are treated at in vitro fertilization (IVF) clinics have trouble conceiving due to ovarian failure (OF), which seems be associated short telomeres and reduced or absent telomerase activity their granulosa cells. Indeed, telomere pathways involved organ dysfunction. However, sexual steroids can stimulate the expression of gene been successfully used prevent attrition. Thus, a strategy improve IVF outcomes with OF could reactivation using steroids.We conducted double-blind,...