A5049959002- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Reproductive Biology and Fertility
- Tissue Engineering and Regenerative Medicine
- Sperm and Testicular Function
- Birth, Development, and Health
- Thyroid Cancer Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Plant tissue culture and regeneration
- RNA Interference and Gene Delivery
- Renal and Vascular Pathologies
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Molecular Biology Techniques and Applications
- Sulfur Compounds in Biology
- Metabolomics and Mass Spectrometry Studies
- Glutathione Transferases and Polymorphisms
- Pluripotent Stem Cells Research
- Selenium in Biological Systems
- Epigenetics and DNA Methylation
- Renin-Angiotensin System Studies
Instituto de Investigación Sanitaria La Fe
2020-2024
Instituto de Investigaciones Biomédicas Sols-Morreale
2023
Universidad Autónoma de Madrid
2023
Universitat de Lleida
2021
Valencian Infertility Institute
2020
Ovarian aging is the main cause of infertility and telomere attrition common to both fertility disorders. Senescence-Accelerated Mouse Prone 8 (SAMP8) model has shortened lifespan premature infertility, reflecting signs reproductive senescence described in middle-aged women. Thus, our objective was study SAMP8 female pathway at point senescence. The control mice monitored. Telomere length (TL) measured by situ hybridization blood ovary. Telomerase activity (TA) analyzed telomere-repeat...
Metabolic adaptations are a hallmark of cancer and may be exploited to develop novel diagnostic therapeutic tools. Only about 50% the patients who undergo thyroidectomy due suspicion thyroid actually have disease, highlighting limitations current We explored possibility using non-invasive blood tests accurately diagnose cancer. analyzed tissue samples from two independent cohorts undergoing at Hospital Universitario 12 de Octubre (Madrid, Spain). As expected, histological comparisons...
Most women who are treated at in vitro fertilization (IVF) clinics have trouble conceiving due to ovarian failure (OF), which seems be associated short telomeres and reduced or absent telomerase activity their granulosa cells. Indeed, telomere pathways involved organ dysfunction. However, sexual steroids can stimulate the expression of gene been successfully used prevent attrition. Thus, a strategy improve IVF outcomes with OF could reactivation using steroids.We conducted double-blind,...
In brief COVID-19 does not affect the telomeres or fertility outcomes in mild cases. However, women with severe symptoms, of granulosa cells are shorter, and oocyte maturation rate is decreased. Abstract The coronavirus SARS-CoV-2 causes disease affects primarily lungs also other organs, causing accelerated cell aging. One main pathways involved aging telomere attrition, which ultimately leads to defective tissue regeneration organ dysfunction. Indeed, short aged people aggravate survivors...
Metabolic adaptations are a hallmark of cancer and may be exploited to develop novel diagnostic therapeutic tools. Only about 50% the patients who undergo thyroidectomy due suspicion thyroid actually have disease, highlighting limitations current We explored possibility using non-invasive blood tests accurately diagnose cancer. analyzed tissue samples from 2 independent cohorts undergoing at Hospital Universitario 12 de Octubre (Madrid, Spain). As expected, histological comparisons...
Abstract Study question Could the administration of a synthetic steroid -danazol- for 3 months reactivate telomerase activity and lengthen telomeres in patients with DOR? Summary answer Danazol treatment resulted an increase mean leukocyte telomeric length (TL) but did not improve fertility results after nearest ovarian stimulation (OS). What is known already A primary molecular cause aging telomere attrition, given that accumulation critically short leads organ dysfunction. Telomere...