A5021610721- Antiplatelet Therapy and Cardiovascular Diseases
- Platelet Disorders and Treatments
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Quinazolinone synthesis and applications
- Andrographolide Research and Applications
- Neurological Disease Mechanisms and Treatments
- Synthesis of Organic Compounds
- Pharmacological Effects of Natural Compounds
- Retinoids in leukemia and cellular processes
- Mast cells and histamine
- Antioxidant Activity and Oxidative Stress
- Plant-based Medicinal Research
- NF-κB Signaling Pathways
- Flavonoids in Medical Research
- Medicinal Plants and Bioactive Compounds
- Cell Adhesion Molecules Research
- Neurological Disorders and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Phytochemicals and Antioxidant Activities
- Metal complexes synthesis and properties
- Synthesis and Biological Evaluation
- Heme Oxygenase-1 and Carbon Monoxide
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
Pondicherry University
2022-2024
Taipei Medical University
2014-2023
Penn State Milton S. Hershey Medical Center
2019
Institute of Medical Sciences
2010-2014
Bharathidasan University
2005-2010
Joseph Eye Hospital
2010
Deleted Institution
2010
Mackay Memorial Hospital
2009
Andrographis paniculata (Burm. F) Nees, generally known as "king of bitters," is an herbaceous plant in the family Acanthaceae. In China, India, Thailand, and Malaysia, this has been widely used for treating sore throat, flu, upper respiratory tract infections. Andrographolide, a major bioactive chemical constituent plant, shown anticancer potential various investigations. Andrographolide its derivatives have anti-inflammatory effects experimental models asthma, stroke, arthritis. recent...
Astaxanthin, a potent antioxidant carotenoid, plays major role in modulating the immune response. In this study, we examined immunomodulatory effects of astaxanthin on cytokine production primary cultured lymphocytes both vitro and ex vivo. Direct administration (70-300 nM) did not produce cytotoxicity lipopolysaccharide (LPS, 100 µg/ mL)- or concanavalin A (Con A, 10 mL)-activated lymphocytes, whereas alone at 300 nM induced proliferation splenic (p < 0.05) vitro. Although astaxanthin, with...
Recent studies have demonstrated that transcription factor nuclear (NF)-κB inhibition may contribute to the protective anti-inflammatory actions of andrographolide, an abundant component plants genus Andrographis. However, precise mechanism by which andrographolide inhibits NF-κB signaling remains unclear. We thus investigated involved in suppression rat vascular smooth muscle cells (VSMCs) exposed proinflammatory stimuli, LPS, and IFN-γ. Andrographolide was shown suppress LPS/IFN-γ-induced...
Studies have discovered that different extracts of Evodia rutaecarpa and its phytochemicals show a variety biological activities associated with inflammation. Although rutaecarpine, an alkaloid isolated from the unripe fruit E. rutaecarpa, has been exposed to anti-inflammatory properties, mechanism action not well studied. Thus, this study investigated molecular mechanisms rutaecarpine (RUT) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. RUT reserved production nitric oxide (NO)...
Platelets assume a pivotal role in the cardiovascular diseases (CVDs). Thus, targeting platelet activation is imperative for mitigating CVDs. Ginkgetin (GK), from Ginkgo biloba L, renowned its anticancer and neuroprotective properties, remains unexplored concerning impact on activation, particularly humans. In this investigation, we delved into intricate mechanisms through which GK influences human platelets. At low concentrations (0.5-1 μM), exhibited robust inhibition of collagen...
Overexpression of matrix metalloproteinases (MMPs) is a major pathological factor causing cartilage destruction in osteoarthritis (OA). This study aimed to investigate the effects and mechanisms sesamol on expression MMPs activated chondrosarcoma cells. Sesamol significantly attenuated TNF-α- IL-1β-induced gelatinolysis MMP-9 concentration-dependent manner SW1353 Additionally, both MMP-1 -13 stimulated by PMA were inhibited sesamol. On other hand, NF-κB signaling activation through IκB-α...
Hinokitiol, a natural monoterpenoid from the heartwood of Calocedrus formosana, has been reported to have anticancer effects against various cancer cell lines. However, detailed molecular mechanisms and inhibiting roles hinokitiol on adenocarcinoma A549 cells remain be fully elucidated. Thus, current study was designed evaluate effect migration human lung in vitro. The data demonstrates that does not effectively inhibit viability at up 10 µM concentration. When treated with non-toxic doses...
Basal macroautophagy/autophagy has recently been found in anucleate platelets. Platelet autophagy is involved platelet activation and thrombus formation. However, the mechanism underlying platelets require further clarification. Our data revealed that LC3-II formation SQSTM1/p62 degradation were noted H2O2-activated human platelets, which could be blocked by 3-methyladenine bafilomycin A1, indicating may cause autophagy. AMPK phosphorylation MTOR dephosphorylation also detected, block of...
Inflammation is a major root of several diseases such as allergy, cancer, Alzheimer’s, and others, the present state existing drugs provoked researchers to search for new treatment strategies. Plants are regarded be unique sources active compounds holding pharmacological properties, they offer novel designs in development therapeutic agents. Therefore, this study aimed explore anti-inflammatory mechanism esculetin lipoteichoic acid (LTA)-induced macrophage cells (RAW 264.7). The relative...
Oxidative stress is believed to contribute the pathogenesis of hypercholesterolaemic atherosclerosis; hence, various antioxidant compounds are being evaluated for potential anti-atherogenic effects. The present study assessed efficacy epigallocatechin gallate (EGCG), an component plant Camellia sinensis, in improving serum lipid profile and parameters erythrocytes cardiac tissue rats fed atherogenic diet. In male albino Wistar diet 30 days, significantly increased levels total cholesterol,...
Hinokitiol ( β -thujaplicin), a tropolone-related compound found in the heartwood cupressaceous plants, is widely used hair tonics, tooth pastes, cosmetics, and food as an antimicrobial agent. Increasing evidence has confirmed that hinokitiol exhibits anticancer activity variety of cancers through inhibition cell proliferation. In present study, we have investigated neuroprotective effect mechanisms rats against middle cerebral artery occlusion (MCAO)-induced thromboembolic stroke. Treatment...
Vascular inflammatory process has been suggested to play a key role in the initiation and progression of atherosclerosis, major complication diabetes mellitus. Recent studies have shown that brazilin exhibits antihepatotoxic, antiplatelet, cancer preventive, or anti-inflammatory properties. Thus, we investigated whether suppresses vascular induced by high glucose (HG) cultured human umbilical vein endothelial cells (HUVEC). HG nitrite production, lipid peroxidation, intracellular reactive...
Melanoma is extremely resistant to chemotherapy and the death rate increasing hastily worldwide. Extracellular matrix promotes migration invasion of tumor cells through production metalloproteinase (MMP)-2 -9. Evidence has shown that natural dietary antioxidants are capable inhibiting cancer cell growth. Our recent studies showed hinokitiol, a bioactive compound, inhibited vascular smooth muscle proliferation platelets aggregation. The present study investigate anticancer efficacy hinokitiol...
Esculetin, a bioactive 6,7-dihydroxy derivative of coumarin, possesses pharmacological activities against obesity, diabetes, renal failure, and cardiovascular disorders (CVDs). Platelet activation plays major role in CVDs. Thus, disrupting platelet represents an attractive therapeutic target. We examined the effect esculetin human experimental mouse models. At 10–80 μM, inhibited collagen- arachidonic acid-induced aggregation washed platelets. However, it had no effects on other agonists...