A5101645318- Cellular transport and secretion
- 3D Printing in Biomedical Research
- Neuroscience and Neuropharmacology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Lipid Membrane Structure and Behavior
- Various Chemistry Research Topics
- Molecular Sensors and Ion Detection
- Hearing Loss and Rehabilitation
- Supramolecular Self-Assembly in Materials
- Neurogenesis and neuroplasticity mechanisms
- Plant Molecular Biology Research
- RNA regulation and disease
- Acoustic Wave Phenomena Research
- Chemical Synthesis and Analysis
- Single-cell and spatial transcriptomics
University of Göttingen
2022-2024
Universitätsmedizin Göttingen
2022-2024
Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103
2024
Tissue Dynamics (Israel)
2024
Max Planck Institute for Multidisciplinary Sciences
2022-2024
University of Chicago
2022
Abstract Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic tethers vesicles at the presynaptic active zone (AZ) and might act as a super-scaffold organizing AZ topography. Here we employed synthetic biology approach to reconstitute ribbon-type AZs in HEK293 cells for probing their minimal molecular requirements studying Ca 2+ channel clustering. Co-expressing membrane-targeted version AZ-protein Bassoon core protein RIBEYE, observed...
Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic tethers vesicles at the presynaptic active zone (AZ) and might act as a super-scaffold organizing AZ topography. Here we employed synthetic biology approach to reconstitute ribbon-type AZs in HEK293 cells for probing their minimal molecular requirements studying Ca 2+ channel clustering. Co-expressing membrane-targeted version AZ-protein Bassoon core protein RIBEYE, observed structures...
Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic tethers vesicles at the presynaptic active zone (AZ) and might act as a super-scaffold organizing AZ topography. Here we employed synthetic biology approach to reconstitute ribbon-type AZs in HEK293 cells for probing their minimal molecular requirements studying Ca 2+ channel clustering. Co-expressing membrane-targeted version AZ-protein Bassoon core protein RIBEYE, observed structures...
High-throughput screening based on molecular simulation, machine learning and black-box optimization identifies promising candidates for forming self-assembled peptide vesicles.
Abstract Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tireless-ly transmit sound information at high rates over long time periods extreme temporal precision. This functional specialization is essential for precise encoding and attributed to a distinct molecular machinery unique players or splice variants compared conventional neuronal synapses. Among these the active zone (AZ) scaffold protein piccolo/aczonin, which represented by its...