A5074927931- Economic and Financial Impacts of Cancer
- Cancer Treatment and Pharmacology
- Cancer therapeutics and mechanisms
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Advanced MRI Techniques and Applications
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cancer survivorship and care
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Multiple and Secondary Primary Cancers
- Antifungal resistance and susceptibility
- MRI in cancer diagnosis
- Lymphoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Palliative Care and End-of-Life Issues
- Cutaneous Melanoma Detection and Management
- Cancer Immunotherapy and Biomarkers
City of Hope
2018-2024
Beckman Research Institute
2021-2024
City Of Hope National Medical Center
1984-2024
University of Southern California
1990-2018
Children's Oncology Group
1999-2015
Tennessee Oncology
2012
Nashville Oncology Associates
2012
Memorial Sloan Kettering Cancer Center
2012
Breast Center
2012
East Carolina University
2010
PURPOSE: This randomized trial was designed to determine whether paclitaxel plus carboplatin (PC) offered a survival advantage over vinorelbine cisplatin (VC) for patients with advanced non–small-cell lung cancer. Secondary objectives were compare toxicity, tolerability, quality of life (QOL), and resource utilization. PATIENTS AND METHODS: Two hundred two received VC (vinorelbine 25 mg/m 2 /wk 100 /d, day 1 every 28 days) 206 PC (paclitaxel 225 3 hours area under the curve 6, 21 days)....
PURPOSE To assess the feasibility of concurrent chemotherapy and irradiation (chemoRT) followed by surgery in locally advanced non-small-cell lung cancer (NSCLC) a cooperative group setting, to estimate response, resection rates, relapse patterns, survival for stage subsets IIIA(N2) versus IIIB. PATIENTS AND METHODS Biopsy proof either positive N2 nodes (IIIAN2) or N3 T4 primary lesions (IIIB) was required. Induction two cycles cisplatin etoposide plus chest RT 45 Gy. Resection attempted if...
Abstract The purpose of this study was to develop an instrument for measuring the quality life cancer patients. Quality measured with 14 linear analogue scale items concerning general physical condition, normal activities, and personal attitudes on life. tool tested four subject groups: oncology outpatients receiving chemotherapy (43) or radiation therapy (39), inpatients (48), nonpatient volunteers (48). Test‐retest reliability coefficients these samples ranged from r = .11 .97, 52 56...
The reticuloendothelial system of mice bearing EMT6 tumors was effectively blocked by intravenous injections small unilamellar vesicles that incorporated a 6-aminomannose derivative cholesterol in the lipid bilayer. Neutral liposomes loaded with indium-111-nitrilotriacetic acid were then injected. Fifty percent more radioactivity deposited animals systems than controls. Twenty-four hours after injection radioactive vesicles, well-defined tumor images observed whole-body gamma camera...
Abstract Two phytohemagglutinins (PHA) with similar specificities for cell surface carbohydrate receptors were partially purified from the commercial mushroom Agaricus bisporus. One of PHAs, which was greater than 90% pure, iodinated and used in binding studies to determine number receptor sites on different types. Human erythrocytes contained 6.8 x 106 per cell, whereas normal human lymphocytes 12.7 patients chronic lymphocytic leukemia had 2.8 receptors. The ratio A. bisporus PHA Phaseolus...
Histopathologic peer review of specimens from 216 consecutive patients with soft-tissue or bone sarcomas on Southeastern Cancer Study Group protocols was performed by a panel three pathologists. Subtype sarcoma, degree confidence in diagnosis, and grade were compared agreement disagreement pathologic opinion the primary member institution v pathology panel. The most common sarcoma leiomyosarcoma, followed malignant fibrous histiocytoma, fibrosarcoma, liposarcoma, schwannoma,...
CDK4/6 inhibitors modulate immune response in breast cancer. This phase I/II trial was designed to test the safety and efficacy of palbociclib, pembrolizumab letrozole women with hormone receptor positive (HR+) human epidermal growth factor 2 negative (HER2-) metastatic cancer (MBC).Women stage IV HR+ HER2- MBC were enrolled treated letrozole. Primary end-points safety, tolerability efficacy.Between November 2016 July 2020, 23 patients 20 evaluable for response, including 4 cohort 1 16 2....
The pharmacokinetics of 5-fluorouracil (5FU) were studied in vivo patients with discrete tumors and rabbits bearing VX2 by using 19F NMR spectroscopy. human studies conducted a 1.5-T Magnetom magnetic resonance imager (Siemens), the rabbit 4.7-T GE/Nicolet 33-cm bore magnet. Free 5FU was detected four six all but not normal tissues. No other metabolites seen these tumors, contrary to extensive catabolism we had previously documented spectroscopy both animal livers. tumor pool free those that...
Twenty-four patients with proven primary and/or metastatic cancer received single intravenous injections of phospholipid vesicles containing 0.5 mCi Indium-111. Gamma camera scintigraphy 1 to 72 hours later visualized tumors in 22 (92%), including carcinomas breast, lung, colon, prostate, kidney, cervix, thyroid, and soft tissue sarcoma, lymphoma, melanoma. Tumor sites that were identified included tissues, bone, liver, lymph node, spinal cord. There only two false-positive images four...
Quitting smoking improves patients' clinical outcomes, yet is not commonly addressed as part of cancer care. The Cancer Center Cessation Initiative (C3I) supports National Institute-designated centers to integrate tobacco treatment programs (TTPs) into routine C3I vary in size, implementation strategies used, and approaches. We examined associations these contextual factors with reach cessation effectiveness.
We previously reported that fluorouracil (5FU) accumulation and metabolism in human livers tumors can be studied by vivo nuclear magnetic resonance spectroscopy (NMRS). have extended these observations evaluating the pharmacokinetics of 5FU 11 patients with carcinoma breast, colon, endometrium, cervix, kidney, using 19F-NMRS a 1.5 Magnetom (Siemens Medical Systems, Cerrito, CA) imaging unit (MRI). These NMRS measurements detected long-lived tumor pool six our including carcinomas pelvis,...
Four patients with cancer developed superior vena cava syndrome following placement of a central venous catheter (Broviac or Hickman catheter) without evidence mediastinal tumoral involvement. Diagnostic and therapeutic considerations are discussed.
A total of 260 patients with clinically localized melanoma (Stage I) from 18 medical institutions in the Southeastern Cancer Study Group were randomized to receive either surgical treatment alone, or surgery plus Corynebacterium parvum immunotherapy. multivariant analysis (Cox regression model) nine prognostic factors was performed on 110 a minimum two years follow-up. The dominant variables thickness (P = 0.0007) and anatomic location (trunk versus other, P 0.015). Disease-free survival...
From the Wilshire Oncology Medical Group, Los Angeles, California, St. Vincents Community Hospital Program, and Queen of Valley West Covina, California.
It is increasingly important to have timely information about the economic impact of new cancer therapies in today's cost-conscious environment. Nearly 170 000 people are diagnosed with lung annually United States. We performed an analysis alongside Southwest Oncology Group Trial S9509 estimate cost-effectiveness cisplatin plus vinorelbine versus carboplatin paclitaxel for patients advanced non-small-cell cancer. There were no statistically significant differences survival or cancer-related...
A pilot study of the use verapamil and adriamycin in patients with advanced malignancy was conducted to determine if two drugs could be safely combined explore whether antitumor responses were frequent. The dosage 50 mg/M2 every 3 weeks. Eight doses given orally 6 hours, being administered after fourth dose. In five 240 mg taken hours produced unacceptable nausea, vomiting, hypotension, arrhythmia. eight patients, 120 tolerated moderately well. four adriamycin-resistant combination one...
In a previously reported Phase I trial, we observed therapy-associated declines in circulating myeloid-derived suppressor cells (MDSCs) with the administration of white button mushroom (WBM) tablets prostate cancer (PCa) patients. These observations led us to hypothesise that WBM could mitigate PCa progression by suppressing MDSCs.