A5009633874- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Pelvic and Acetabular Injuries
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Cardiac tumors and thrombi
- Bone fractures and treatments
- Colorectal and Anal Carcinomas
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Management of metastatic bone disease
- Bone Tumor Diagnosis and Treatments
- Cancer Genomics and Diagnostics
- Spinal Fractures and Fixation Techniques
- Genetic factors in colorectal cancer
- Pregnancy-related medical research
- Lymphoma Diagnosis and Treatment
- Corporate Governance and Management
- Cardiac Valve Diseases and Treatments
- Elbow and Forearm Trauma Treatment
- Scoliosis diagnosis and treatment
- Bone Metabolism and Diseases
- Musculoskeletal synovial abnormalities and treatments
- Advancements in Materials Engineering
- German legal, social, and political studies
TU Dortmund University
2025
Charité - Universitätsmedizin Berlin
2015-2024
Freie Universität Berlin
2020-2024
Humboldt-Universität zu Berlin
2020-2024
Hochschule für Technik und Wirtschaft des Saarlandes
2023
Klinikum rechts der Isar
2016
Harborview Medical Center
2016
University of Washington
2016
Universitätsklinikum Würzburg
2013
University of Würzburg
2013
Acetabular fractures, traditionally linked to high-impact trauma in younger adults, are increasingly observed the elderly due falls and poor bone quality. This demographic shift necessitates updated treatment approaches. study analyzes trends evolution over a decade using German pelvic fracture registry.
The risk of prosthetic joint infection (PJI) in mega-prosthesis for malignancy is increased compared with non-tumor cases. While several studies describe PJI tumor-related arthroplasty, prospective comparing characteristics among different joints are limited. present study analyzes mega-arthroplasty hip, knee, and shoulder compares the epidemiology, diagnosis, microbe spectrum, treatments, outcomes between entities.The retrospective inclusion criteria were as follows: (1) (2) or a total...
The demographic change in industrial countries leads to an increasing population that sustains acetabular fracture advanced age. Some authors predicted elderly individuals be the most rapidly growing subgroup of patients currently sustaining fractures. Gold standard treatment fractures remains open reduction and internal fixation. Relevant factors impeding surgical include significantly decreased bone stock incapability partially weight bear following surgery. Therefore, special...
Soft tissue sarcomas (STSs) are a diverse group of rare malignant soft tumors with high disease burden. Treatment protocols complex and, to this day, precise recommendation for the surgical margin width is lacking. The present study aims analyze margins in STS resection specimens and them local systemic disease-free survival as well most frequent histologic subtypes. A total 169 consecutive patients diagnosed treated curative intent our institution following primary localized extremities or...
The antibody targeting platelet-derived growth factor receptor alpha (PDGFRA), olaratumab, was approved in 2016 for metastatic soft tissue sarcoma (STS) combination with doxorubicin based on promising results of a phase Ib/II trial by the Food and Drug Administration (FDA). However, recently III ANNOUNCE could not confirm additional value olaratumab this context.Here, retrospective analysis we share our single-centre experience olaratumab/doxorubicin STS including n = 32 patients treated...
Abstract Background Standard treatment of soft tissue sarcoma (STS) the extremities includes limb-sparing surgery combined with pre- or postoperative radiotherapy (RT). The role perioperative chemotherapy (CTX) remains uncertain. STS patients high-risk features for local recurrence, distant metastases, and increased mortality may require additional systemic therapy. objective this study was to evaluate predictors outcome regarding control (LC), overall survival (OS), freedom from metastases...
Localized adult high-grade soft tissue sarcomas (STS) usually require multimodality treatment including surgery, radiotherapy, chemotherapy and hyperthermia. If maximal preoperative tumor-shrinkage is envisaged, neoadjuvant + radiation (CRT) often applied, however at the expense of relatively high toxicities increased postoperative complication rates. This study aims to compare CRT with regional hyperthermia (HCT) regarding histopathological response, toxicity outcome.In this retrospective...
Abstract Background Ewing family of tumors (EFT) is rarely diagnosed in patients (pts) over the age 18 years (years), and data on clinical course outcome adult EFT pts sparse. Methods In this retrospective analysis, we summarize our experience with pts. From 2002 to 2020, identified 71 whom 58 were evaluable for final analysis. Results Median was 31 (18–90 years). Pts presented skeletal ( n = 26), extra‐skeletal primary disease =32). Tumor size ≥8 cm 20 19 metastasized at first diagnosis....
Introduction: Over the past few decades, tumor arthroplasty has evolved into an established therapeutic approach for addressing bone defects following resection in extremities. As diagnosis a significant impact on patients’ lives, it is important to give clear expectations functional recovery. Therefore, we investigated both outcomes and quality of life (QoL) after malignant hip tumors. Methods: This retrospective study included patients who had undergone resections tumors with consecutive...
Abstract Centralising soft tissue sarcoma (STS) treatment in expert centres and implementing comprehensive therapy concepts through interdisciplinary tumour boards (ITB) has led to significant progress. However, our knowledge on the implementation of ITB recommendations its impact patient outcome is limited. In this retrospective analysis, we examined a cohort 222 adult patients (pts) with primary STS who were presented Charité Comprehensive Cancer Centre between 2015 2020. localised disease...
In recent years, an increase in periprosthetic femur fractures has become apparent due to the increased number of hip replacements. case Vancouver type B1 fractures, locking plate systems offer safe procedures. This study compared distal lateral (LOQTEQ®, aap Implantate AG) with a standard L.I.S.S. LCP® (DePuy Synthes) regarding their biomechanical properties fixation after arthroplasty. We hypothesized that new LOQTEQ system superior stability and durability comparison. Eighteen artificial...