A5013460931- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Digital Mental Health Interventions
- Cellular transport and secretion
- Health and Well-being Studies
- Multiple Sclerosis Research Studies
- Stress Responses and Cortisol
- Technology and Human Factors in Education and Health
- Peripheral Neuropathies and Disorders
- Mental Health and Psychiatry
- Healthcare Systems and Public Health
- Autoimmune Neurological Disorders and Treatments
- Youth Substance Use and School Attendance
- Multisensory perception and integration
Aalto University
2016-2023
University of Helsinki
2016-2023
Finnish Institute for Health and Welfare
2016-2023
Helsinki University Hospital
2018
Background While group-level functional alterations have been identified in many brain regions of psychotic patients, multivariate machine-learning methods provide a tool to test whether some such could be used differentiate an individual patient. Earlier studies focused on data collected from chronic patients during rest or simple tasks. We set out unravel activation patterns naturalistic stimulation first-episode psychosis (FEP). Method recorded activity 46 FEP and 32 control subjects...
Previous functional magnetic resonance imaging studies have reported widespread brain connectivity alterations in patients with psychosis. These mostly used either resting-state or simple-task paradigms, thereby compromising experimental control ecological validity, respectively. Additionally, a conventional intrasubject analysis, it is difficult to identify which connections relate extrinsic (stimulus-induced) and intrinsic (non-stimulus-related) neural processes.
Psychotic disorders have been suggested to derive from dysfunctional integration of signaling between brain regions. Earlier studies found several changes in functional network synchronization as well altered topology patients with psychotic disorders. However, used mainly resting-state that makes it more difficult link alterations any specific stimulus or experience. We set out examine connectivity graph (topological) measures and their association symptoms first-episode psychosis during...
An increase in brain white matter hyperintensities (WMHs) and a decrease fractional anisotrophy (FA) have been detected bipolar I (BPI), II (BPII), major depressive disorder (MDD) patients. Their relationship, differences diagnostic groups are obscure. Longitudinal studies rare.After 5-year follow-up, we evaluated WMHs BPI, BPII, MDD patients as compared with controls, studied the effects of clinical variables. We also explored associations variables cross-sectional whole FA.Eight 8 6...
There is evidence of low-grade inflammation in psychosis, as measured by the high-sensitivity C-reactive protein (hs-CRP). Significant weight gain common during first months antipsychotic treatment. In general population, overweight and obesity often lead to systemic inflammation. Lifestyle factors, such smoking, can contribute pro-inflammatory changes. The metabolic changes people with first-episode psychosis (FEP) taking place after onset be especially harmful these individuals are...
The brain basis of psychotic disorders is still inadequately understood; however, evidence strongly suggests a central role the dysfunctional integration signaling between systems, i.e. “dysconnectivity”. Resting-state functional connectivity (FC) studies chronic schizophrenia have revealed several illness-related, network-level changes. Patients shown reduced modular structure, changes in subcortical-cortical interactions, increased FC within default-mode network (DMN) and fronto-parietal...
Functional alterations of the default mode network (DMN) are frequently reported in psychotic disorders, but functional role these remains poorly known. In addition to previous studies that have applied different types tasks or recorded resting-state neuroimaging data, there has recently been more interest use movie stimuli studying brain functioning patient populations, because this could provide a naturalistic account real life-like situations. Seventy-one first-episode psychosis (FEP)...