A5089341743- Sleep and related disorders
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Neuroscience of respiration and sleep
- Health, Environment, Cognitive Aging
- Infant Development and Preterm Care
- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
- Sleep and Wakefulness Research
- Maternal Mental Health During Pregnancy and Postpartum
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Early Childhood Education and Development
- Psychosomatic Disorders and Their Treatments
- Infant Health and Development
- Neural dynamics and brain function
- Youth Substance Use and School Attendance
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Adolescent and Pediatric Healthcare
- Spanish Culture and Identity
- Neural and Behavioral Psychology Studies
- Cannabis and Cannabinoid Research
University of Birmingham
2018-2025
Finnish Institute for Health and Welfare
2017-2023
Birmingham and Solihull Mental Health NHS Foundation Trust
2023
Centre for Mental Health
2023
University of Helsinki
2016-2022
Helsinki University Hospital
2019
Research Institute Hospital 12 de Octubre
2012-2018
Centro de Investigación Biomédica en Red
2015
Centro de Investigación Biomédica en Red de Salud Mental
2015
Hospital Universitario 12 De Octubre
2011-2015
Background Little is still known about the long-term impact of childhood and adolescent persistent depression anxiety in adulthood. Aims To investigate anxiety, depression, comorbid across adolescence on development multiple adverse outcomes young Method This study used data from 8122 participants Avon Longitudinal Study Parents Children cohort. The Development Well-Being Assessment (DAWBA) examined child symptomatology. DAWBA generalised mood subscales at 8, 10 13 years were selected, a...
Although there is recent evidence that cells from the peripheral immune system can gain access to central nervous in certain conditions such as multiple sclerosis, their role has not been assessed psychosis. Here, we aimed explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included study. For each participant, a T1 structural image...
Short sleep duration over a prolonged period in childhood could have detrimental impact on long-term mental health, including the development of psychosis. Further, potential underlying mechanisms these associations remain unknown.
Background A substantial subset of patients with major depressive disorder (MDD) experience treatment-resistant depression (TRD), typically defined as failure to respond at least two sequential antidepressant trials adequate dose and length. Aims To examine clinical service-level associations TRD, the experiences people TRD clinicians involved in their care within a large, diverse National Health Service trust UK. Method This mixed-methods study integrated quantitative analysis electronic...
Abstract Fluctuations with power-law scaling and long-range temporal correlations (LRTCs) are characteristic to human psychophysical performance. Systems operating in a critical state exhibit such LRTCs, but phenomenologically similar fluctuations LRTCs may also be caused by slow decay of the system’s memory without system being critical. Theoretically, criticality endows greatest representational capacity flexibility transitions. Without criticality, however, slowly decaying would predict...
<h3>Importance</h3> Persistent nightmares in childhood have been prospectively associated with psychosis and borderline personality disorder (BPD) adolescence. However, the extent to which this association is also true for behavioral sleep problems still unknown, potential mechanisms are unexplored. <h3>Objective</h3> To examine prospective associations between several parent-reported early psychotic BPD symptoms at 11 13 years of age mediation by depression 10 age. <h3>Design, Setting,...
Sleep difficulties are associated with cognitive and behavioral problems in childhood. However, it is still unclear whether early sleep related to later development. We studied parent-reported duration, night awakenings, childhood symptoms of inattention hyperactivity at the age 5 years.Our study based on Child-Sleep birth cohort initially comprising 1673 families, which 713 were retained years. used Brief Infant Questionnaire Questionnaire, filled out by parents when their child was 3, 8,...
(1) Background: There is a growing interest in investigating the relationship between sleep and mental health development adolescents. This study aims to further investigate this by identifying specific associations several problems adolescents areas, role of gender these associations. (2) Methods: Data from Millennium cohort survey containing 11,553 individuals at 13-14 years old was included. Nighttime duration bedtime during weekdays weekends, night awakening frequency, onset latency were...
Abstract Background Evidence regarding the rate of relapse in people with bipolar disorder (BD), particularly from UK, is lacking. This study aimed to evaluate and associations clinician-defined over 5 years a large sample BD patients receiving routine care UK mental health service. Method We utilised de-identified electronic records at baseline. Relapse was defined as either hospitalisation, or referral acute crisis services, between June 2014 2019. calculated 5-year examined...
The concurrence of sleep and socio-emotional development in children is well accepted. However, the predictive role problems infancy emotional behavioural later childhood remain still unclear. Therefore, this study we examined associations between early internalising, externalising dysregulation symptoms toddlers.1679 families entered during pregnancy 936 participated at 24 months. Parent-reported duration, sleep-onset latency, night wakings, proportion daytime bedtime 3, 8, 18 months were...
Summary Sleep problems in young children are among the most common concerns reported to paediatricians. is thought have important regulatory functions, and sleep difficulties early childhood linked several psychosocial physiological problems. Moreover, prenatal factors been found influence infants’ sleep. Among them, of studies focused on maternal depression and/or anxiety as potential risk for childhood, whereas other relevant psychological during pregnancy not received much attention....
Sensory gating deficits are commonly found in patients with schizophrenia. However, there is still scarce research on this issue. Thirty-eight first-episode psychosis (FEP) were compared to thirty-eight controls. A condition-test paradigm of event-related potentials (ERP), prepulse inhibition (PPI), and some specific tasks the MATRICS Consensus Cognitive Battery (MCCB) used (i.e., TMT, BACS-SC, Fluency for processing speed CPT-IP attention vigilance). The ERP components measured P50, N1, P2....
The impacts of postnatal psychiatric disorders on different types mental health problems in offspring are unclear. We investigated the prospective associations maternal depression, and anxiety, with psychotic-like experiences Borderline Personality Disorder symptoms, adolescence, examined whether these were independent each other.
Importance Research suggests that low-grade, nonresolving inflammation may predate adult mental and physical illness. However, evidence to date is largely cross-sectional or focuses on single disorder outcomes. Objectives To examine trajectories of as measured by C-reactive protein (CRP) levels in a large sample children adolescents, explore associations between different identified related cardiometabolic health outcomes early adulthood. Design, Setting, Participants In longitudinal cohort...
Abstract Circadian rhythms refer to biological that have an endogenous period length of approximately 24 hr. However, not much is known about the variance in development sleep–wake rhythm. The study objectives were (a) describe normative variation a rhythm infancy, (b) assess whether slower related sleep quality and (c) evaluate factors are based on representative birth cohort. Questionnaires at ages 3 ( n = 1,427) 8 months 1,302) actigraph measurement 372) available. Infants with...
<h3>Importance</h3> Cognitive deficits are core features of mental disorders and important in predicting long-term prognosis. However, it is still unknown whether individual patterns cognitive predate specific disorders. <h3>Objective</h3> To investigate the specificity associations attention, working memory, inhibition childhood with borderline personality disorder (BPD), psychosis, depression, hypomania adolescence young adulthood. <h3>Design, Setting, Participants</h3> This cohort study...
BackgroundPersistent anxiety in childhood and adolescence could represent a novel treatment target for psychosis, potentially targeting activation of stress pathways secondary nonresolving inflammatory response. Here, we examined the association between persistent through with individuals psychotic experiences (PEs) or who met criteria disorder (PD) at age 24 years. We also investigated whether C-reactive protein mediated any association.MethodsData from Avon Longitudinal Study Parents...