A5077645956- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Electroconvulsive Therapy Studies
- Mental Health and Psychiatry
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Obsessive-Compulsive Spectrum Disorders
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Treatment of Major Depression
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Nerve injury and regeneration
- Personality Disorders and Psychopathology
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Autism Spectrum Disorder Research
- COVID-19 and Mental Health
- Advanced Neuroimaging Techniques and Applications
Neuroscience Institute
2015-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Instituto de Salud Carlos III
2018-2025
Centro de Investigación Biomédica en Red de Salud Mental
2016-2025
Hospital Clínic de Barcelona
2016-2025
Universitat de Barcelona
2016-2025
Centre for Biomedical Network Research on Rare Diseases
2016-2024
Associació de la Paràlisi Cerebral
2024
Hospital Clínico San Carlos
2023
Servicio Gallego de Salud
2023
Schizophrenia is a chronic syndrome of unknown etiology, predominantly defined by signs psychosis. The onset the disorder occurs typically in late adolescence or early adulthood. Efforts to study pathophysiological mechanisms stages disease are crucial order prompt intervention. Case-control first-episode psychotic (FEP) patients and matched controls. We recruited 117 during first year after their FEP according DSM-IV criteria 106 gender-, race-, age-matched controls between September 2010...
Abstract Background Social cognition has been associated with functional outcome in patients first episode psychosis (FEP). also neurocognition and cognitive reserve. Although reserve, neurocognitive functioning, social cognition, are related, the direction of their associations is not clear. Therefore, main aim this study was to analyze influence as a mediator between reserve domains on functioning FEP both at baseline 2 years. Methods The sample composed 282 followed up for To whether...
To report the neuropsychiatric features and frequency of NMDA receptor (NMDAR) other neuronal immunoglobulin G antibodies in patients with first episode psychosis (FEP) to assess performance reported warning signs criteria for autoimmune (AP).This was a prospective observational study FEP assessed symptoms, serum CSF (brain immunohistochemistry, cell-based assays, live neurons), AP. Previous series were reviewed.One hundred five included; their median age 30 (range 14-75) years, 44 (42%)...
<h3>Background and Objectives</h3> An important challenge in diagnosing anti–NMDA receptor (NMDAR) encephalitis (NMDARe) is differentiating it from a first episode of psychosis (FEP) caused by psychiatric disease (pFEP). CSF antibody testing distinguishes these diseases, but spinal taps are difficult to obtain facilities. A separate problem the lack biomarkers NMDARe severity outcome. Here we assessed performance neurofilament light chain (NfL) settings. <h3>Methods</h3> In this...
Abstract Background and Hypothesis A pro-inflammatory phenotype has been related to psychotic disorders. The neutrophil-lymphocyte ratio (NLR) is an accessible biomarker that could be helpful characterize this systemic inflammation state. Study Design This study evaluated the NLR in a cohort of 310 subjects with first episode psychosis (FEP) matched group 215 healthy controls, recruited 16 Spanish centers participating PEPs Project. We investigated measures over 2 years prospective,...
Previous studies have indicated systemic deregulation of the proinflammatory or anti-inflammatory balance in individuals with first-episode psychosis (FEP) that persists 12 months later. To identify potential risk/protective factors and associations symptom severity, we assessed possible changes plasma levels neurotrophins (brain-derived neurotrophic factor [BDNF] nerve growth [NGF]) their receptors peripheral blood mononuclear cells (PBMCs). Expression 2 forms BDNF (active TrkB-FL...
Depressive and manic episodes within bipolar disorder (BD) major depressive (MDD) involve altered mood, sleep, activity, alongside physiological alterations wearables can capture. Firstly, we explored whether wearable data could predict (aim 1) the severity of an acute affective episode at intra-individual level 2) polarity euthymia among different individuals. Secondarily, which were related to prior predictions, generalization across patients, associations between symptoms data. We...
Brain volume and thickness abnormalities have been reported in first-episode psychosis (FEP). However, it is unclear if how they are modulated by brain developmental stage (and, therefore, age at FEP as a proxy). This multicenter cross-sectional case-control magnetic resonance imaging (MRI) study. Patients with ( n = 196), 65.3% males, wide span (12–35 y), healthy controls (HC) 157), matched for age, sex, handedness, were scanned 6 sites. Gray matter measurements generated several regions...
Although there is recent evidence that cells from the peripheral immune system can gain access to central nervous in certain conditions such as multiple sclerosis, their role has not been assessed psychosis. Here, we aimed explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included study. For each participant, a T1 structural image...
(1) Background: The cognitive reserve (CR) concept has not been precisely defined in severe mental disorders and estimated using heterogeneous methods. This study aims to investigate develop the psychometric properties of Cognitive Reserve Assessment Scale Health (CRASH), an instrument designed measure CR people with illness; (2) Methods: 100 patients illness (non-affective psychoses affective disorders) 66 healthy controls were included. internal consistency convergent validity CRASH...
Relapsing after a first episode of schizophrenia (FES) is main predictor clinical and functional prognosis. Brain-derived neurotrophic factor (BDNF) plays critical role in neuronal development plasticity, its signaling may be altered by successive relapses. We assessed the impact relapse expression 2 isoforms BDNF tropomyosin-related kinase B (TrkB) receptor (active full-length TrkB-F inactive truncated TrkB-T) peripheral blood mononuclear cells from 53 FES patients remission followed up for...