A5046123088- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Receptor Mechanisms and Signaling
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Adolescent and Pediatric Healthcare
- Diabetes Treatment and Management
- Cell death mechanisms and regulation
- Child and Adolescent Psychosocial and Emotional Development
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Health, Environment, Cognitive Aging
- Child Nutrition and Feeding Issues
- Frailty in Older Adults
- Urticaria and Related Conditions
- Cancer, Lipids, and Metabolism
- Cardiac Ischemia and Reperfusion
- Genomic variations and chromosomal abnormalities
- Whipple's Disease and Interleukins
Universitat de Barcelona
2019-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021-2025
Biomedical Research Institute
2025
Hospital General Universitario Gregorio Marañón
2023
Centro de Investigación Biomédica en Red de Salud Mental
2023
Hospital Clínic de Barcelona
2023
BioCruces Health research Institute
2023
University of the Basque Country
2023
Schizophrenia and bipolar disorder exhibit substantial clinical overlap, particularly in individuals at familial high risk, who frequently present sub-threshold symptoms before the onset of illness. Severe mental disorders are highly polygenic traits, but their impact on stages preceding manifestation remains relatively unexplored. Our study aimed to examine influence risk scores (PRS) sub-clinical outcomes over a 2-year period youth for schizophrenia controls. The sample included 222...
Relapsing after a first episode of schizophrenia (FES) is main predictor clinical and functional prognosis. Brain-derived neurotrophic factor (BDNF) plays critical role in neuronal development plasticity, its signaling may be altered by successive relapses. We assessed the impact relapse expression 2 isoforms BDNF tropomyosin-related kinase B (TrkB) receptor (active full-length TrkB-F inactive truncated TrkB-T) peripheral blood mononuclear cells from 53 FES patients remission followed up for...
Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports common genetic background psychotic metabolic disorders. In this study, we aimed assess the role polygenic risk scores (PRSs) on progression profile in first-episode psychosis (FEP) cohort.Of 231 FEP individuals included 192-220 participants were basal analysis 118-179 longitudinal 6-month models....
Clinical intervention in early stages of psychotic disorders is crucial for the prevention severe symptomatology trajectories and poor outcomes. Genetic variability studied as a promising modulator prognosis, thus novel approaches considering polygenic nature these complex phenotypes are required to unravel mechanisms underlying progression disorder.The sample comprised 233 first-episode psychosis (FEP) subjects with clinical cognitive data assessed periodically 2-year period 150 matched...
Genome-wide association studies (GWAS) have revealed the polygenic nature of treatment-resistant schizophrenia TRS. Gene expression imputation allowed translation GWAS results into regulatory mechanisms and construction gene (GReX) risk scores (GReX-RS). In present study we computed GReX-RS from largest TRS to assess its with clinical features. We perform transcriptome in find GReX associated using brain tissues. Then, for each tissue, constructed a identified genes sample 254 genotyped...
Current treatment for schizophrenia (SZ) ameliorates the positive symptoms, but is inefficient in treating negative and cognitive symptoms. The SZ glutamatergic dysfunction hypothesis has opened new avenues development of novel drugs targeting glutamate storm, an inducer progressive neuropathological changes. Positive allosteric modulators metabotropic receptor 2 (mGluR2), such as JNJ-46356479 (JNJ), reduce presynaptic release glutamate, which previously been demonstrated to attenuate...
Abstract Obsessive-compulsive disorder (OCD) has a complex etiology that seems to include immune dysfunction and alterations in circulating monocytes. To investigate the basis functional dysregulation of monocytes this disease, we analyzed gene expression peripheral pediatric patients with OCD ( N = 102) compared controls 47). We examined primary cultures from participants, under basal conditions exposure lipopolysaccharide (LPS) stimulate response. Whole-genome was assessed 8 controls....
Schizophrenia (SZ) is a heterogeneous mental disorder, affecting ~1% of the worldwide population. One main pathophysiological theories SZ imbalance excitatory glutamatergic pyramidal neurons and inhibitory GABAergic interneurons, involving N-methyl-D-aspartate receptors (NMDAr). This may lead to local glutamate storms coupled with excessive dendritic pruning subsequent cellular stress, including nitrosative during critical period neurodevelopment, such as adolescence. Nitrosative stress...
The search for predictors of antidepressant response is gaining increasing attention, with epigenetic markers attracting a great deal interest. We performed genome-wide study assessing baseline differences in DNA methylation between Responders and Non-Responders.Twenty-two children adolescents, receiving fluoxetine treatment the first time, were classified as or Non-Responders according to CGI-I score after 8 weeks treatment. Genome-wide was profiled using Illumina Infinium MethylationEPIC...
Abstract Little is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits study potential biomarkers. To explore and identify biomarkers for prediction, we analyzed gene expression peripheral blood a cohort schizophrenia patients with less than 5 years evolution who had been evaluated over 3-year follow-up period. A total 91 participants 2EPs project formed sample baseline analysis. Of these, 67 provided biological samples at (36 after 3 31...
Here, we propose an integrative analysis of genome-wide methylation and gene expression to provide new insight into the biological mechanisms Cognitive behavioral therapy (CBT) in pediatric obsessive-compulsive disorder (OCD).Twelve children adolescents with OCD receiving CBT for first time were classified as responders or non-responders after eight weeks CBT. Differentially methylated positions (DMPs) co-expression modules identified using specific R software packages. Correlations between...
A better understanding of schizophrenia subtypes is necessary to stratify the patients according clinical attributes. To explore genomic architecture symptomatology, we analyzed blood co-expression modules and their association with data from in remission after a first episode schizophrenia. In total, 91 participants 2EPS project were included. Gene expression was assessed using Clariom S Human Array. Weighted-gene network analysis (WGCNA) applied identify co-expressed genes test its...
<title>Abstract</title> <bold>Background </bold>This study investigates the relationship between environmental risk factors and severe mental disorders using genome-wide methylation data. Methylation profile scores (MPS) epigenetic clocks were utilized to analyze alterations in a cohort comprising 211 individuals aged 6–17 years. Participants included offspring of schizophrenia (n = 30) bipolar disorder 82) patients, community control group 99). The aimed assess differences MPS indicative...
Current antipsychotics (APs) effectively control positive psychotic symptoms, mainly by blocking dopamine (DA) D2 receptors, but have little effect on negative and cognitive symptoms. Increased glutamate (GLU) release would trigger neurotoxicity, leading to apoptosis synaptic pruning, which is involved in the pathophysiology of schizophrenia. New pharmacological strategies are being developed such as allosteric modulators (PAMs) metabotropic GLU receptor 2 (mGluR2) that inhibit presynaptic...
Abstract Treatment-resistant schizophrenia (TRS) is defined as the absence of symptomatic response to two different adequately administered antipsychotic drugs other than clozapine, which most effective drug in these patients. Gene expression profiling studies could be a valuable tool identifying specific genes and pathways involved mechanism action leading better understanding molecular biology underlying TRS. We analyzed gene co-expression modules (clusters with highly correlated...
Antipsychotics (APs) are associated with weight gain and other metabolic abnormalities such as hyperglycemia, dyslipidemia syndrome. This translational study aimed to uncover the underlying molecular mechanisms identify key genes involved in AP-induced effects. An integrative gene expression analysis was performed four different mouse tissues (striatum, liver, pancreas adipose) after risperidone or olanzapine treatment. The analytical approach combined identification of co-expression modules...
Positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2), such as JNJ-46356479 (JNJ), may mitigate storm during early stages schizophrenia (SZ), which could be especially useful in treatment cognitive and negative symptoms. We evaluated efficacy with JNJ or clozapine (CLZ) reversing behavioral neuropathological deficits induced a postnatal ketamine (KET) mouse model SZ. Mice exposed to KET (30 mg/kg) on days (PND) 7, 9, 11 received CLZ (10 daily adolescent period (PND...