A5064911349- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Adolescent and Pediatric Healthcare
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Mental Health Research Topics
- Birth, Development, and Health
- Obsessive-Compulsive Spectrum Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Diabetes Treatment and Management
- HIV/AIDS Impact and Responses
- Cholesterol and Lipid Metabolism
- Single-cell and spatial transcriptomics
- Genetics and Neurodevelopmental Disorders
- Neural dynamics and brain function
- Frailty in Older Adults
- SARS-CoV-2 and COVID-19 Research
- Ion channel regulation and function
- Pediatric health and respiratory diseases
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Educational Practices and Sociocultural Research
Hospital Clínic de Barcelona
2019-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2025
Fundació Clínic per a la Recerca Biomèdica
2024-2025
Universitat de Barcelona
2019-2024
Centro de Investigación Biomédica en Red de Salud Mental
2019-2024
Hospital General Universitario Gregorio Marañón
2023
BioCruces Health research Institute
2023
University of the Basque Country
2023
Institut de Biomedicina de la Universitat de Barcelona
2020
Centre for Biomedical Network Research on Rare Diseases
2019
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Schizophrenia and bipolar disorder exhibit substantial clinical overlap, particularly in individuals at familial high risk, who frequently present sub-threshold symptoms before the onset of illness. Severe mental disorders are highly polygenic traits, but their impact on stages preceding manifestation remains relatively unexplored. Our study aimed to examine influence risk scores (PRS) sub-clinical outcomes over a 2-year period youth for schizophrenia controls. The sample included 222...
Abstract Epigenetic modifications occur sequentially during the lifespan, but their pace can be altered by external stimuli. The onset of schizophrenia and bipolar disorder is critically modulated stressors that may alter epigenetic pattern, a putative signature marker exposure to environmental risk factors. In this study, we estimated age-related assess differences between young individuals at familial high (FHR) controls association with stressors. sample included 117 (6–17 years) FHR...
Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports common genetic background psychotic metabolic disorders. In this study, we aimed assess the role polygenic risk scores (PRSs) on progression profile in first-episode psychosis (FEP) cohort.Of 231 FEP individuals included 192-220 participants were basal analysis 118-179 longitudinal 6-month models....
Abstract Background Obstetric complications (OCs) are key contributors to psychosis risk. However, it is unclear whether they increase vulnerability independently of genetic risk, in interaction with it, or a manifestation proneness. We examined the role distinct types OCs terms risk and tested interact differently vulnerability, whilst accounting for other known environmental factors. Study Design 405 participants (219 first episode patients 186 healthy volunteers) underwent comprehensive...
Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims explore potential role PRS from major mental disorders cognition on 114 patients recruited in 2EPs Project were included (56 who had not experienced relapse after 3 years enrollment 58 relapsed during 3-year follow-up). for (PRS-SZ), disorder...
Context Classical antiretroviral agents may acutely impact on metabolic, mitochondrial, renal and hepatic function in HIV-infected uninfected persons. Fusion integrase inhibitors are supposed to be safer, but have been scarcely investigated. To avoid any interference with HIV or other antiretrovirals, we assessed markers of these toxicities healthy adult volunteers treated Enfuvirtide (T20) Raltegravir (RAL). Methods Twenty-six participants were randomized T20/90mg vs. placebo (n = 12)...
AIDS and men. Taking risks or taking responsibility? Martin Foreman, ed. (Pp 240; price not stated). London: The Panos Institute Zed books Ltd, 1999. ISBN: 1870670 40X pb; 185649 7445 hb. AIDS men is a contribution of the programme from Institute, which was founded in 1986, to stimulate debate on global environment development issues, particularly marginalised sectors society. Funding for programmes comes Norwegian Red Cross, Swiss Agency Development Cooperation, Swedish International...
Clinical intervention in early stages of psychotic disorders is crucial for the prevention severe symptomatology trajectories and poor outcomes. Genetic variability studied as a promising modulator prognosis, thus novel approaches considering polygenic nature these complex phenotypes are required to unravel mechanisms underlying progression disorder.The sample comprised 233 first-episode psychosis (FEP) subjects with clinical cognitive data assessed periodically 2-year period 150 matched...
Abstract Obsessive-compulsive disorder (OCD) has a complex etiology that seems to include immune dysfunction and alterations in circulating monocytes. To investigate the basis functional dysregulation of monocytes this disease, we analyzed gene expression peripheral pediatric patients with OCD ( N = 102) compared controls 47). We examined primary cultures from participants, under basal conditions exposure lipopolysaccharide (LPS) stimulate response. Whole-genome was assessed 8 controls....
Abstract Epigenetic modifications occur sequentially during the lifespan, but their pace can be altered by external stimuli. The onset of schizophrenia and bipolar disorder is critically modulated stressors that may alter epigenetic pattern, a putative signature marker exposure to environmental risk factors. In this study, we estimated age-related assess differences between young individuals at familial high (FHR) controls association with stressors. sample included 117 (6-17 years) FHR...
<title>Abstract</title> <bold>Background </bold>This study investigates the relationship between environmental risk factors and severe mental disorders using genome-wide methylation data. Methylation profile scores (MPS) epigenetic clocks were utilized to analyze alterations in a cohort comprising 211 individuals aged 6–17 years. Participants included offspring of schizophrenia (n = 30) bipolar disorder 82) patients, community control group 99). The aimed assess differences MPS indicative...
Abstract Cortical GABAergic neuron dysregulation is implicated in schizophrenia (SCZ), but it remains unclear if these changes are due to altered cell proportions or per-cell mRNA changes. We analyzed bulk and type-specific RNAseq data from 1,302 individuals assess SCZ- age-associated interneurons across two neocortical regions. found that younger SCZ cases (age < 70) showed reduced parvalbumin (PVALB) somatostatin (SST) proportions, while older increased compared controls. Earlier onset...
ABSTRACT Background Studies have shown associations between polygenic risk scores for educational attainment (PRS EA ), cognitive reserve (CR), cognition, negative symptoms (NS), and psychosocial functioning in first‐episode psychosis (FEP). However, their specific interactions remain unclear. This study aimed to investigate the mediating roles of CR, NS relationship PRS one year after a FEP. Additionally, we sought explore impact two subtypes on this relationship: diminished Expression...
Current antipsychotics (APs) effectively control positive psychotic symptoms, mainly by blocking dopamine (DA) D2 receptors, but have little effect on negative and cognitive symptoms. Increased glutamate (GLU) release would trigger neurotoxicity, leading to apoptosis synaptic pruning, which is involved in the pathophysiology of schizophrenia. New pharmacological strategies are being developed such as allosteric modulators (PAMs) metabotropic GLU receptor 2 (mGluR2) that inhibit presynaptic...
Cannabis use is highly prevalent in first-episode psychosis (FEP) and plays a critical role its onset prognosis, but the genetic underpinnings promoting both conditions are poorly understood. Current treatment strategies for cannabis cessation FEP clearly inefficacious. Here, we aimed to characterize association between cannabis-related polygenic risk scores (PRS) on clinical course after FEP. A cohort of 249 individuals were evaluated during 12 months. Symptom severity was measured with...
Abstract Treatment-resistant schizophrenia (TRS) is defined as the absence of symptomatic response to two different adequately administered antipsychotic drugs other than clozapine, which most effective drug in these patients. Gene expression profiling studies could be a valuable tool identifying specific genes and pathways involved mechanism action leading better understanding molecular biology underlying TRS. We analyzed gene co-expression modules (clusters with highly correlated...