A5084393887- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Suicide and Self-Harm Studies
- Mental Health Research Topics
- COVID-19 and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Stress Responses and Cortisol
- Psychosomatic Disorders and Their Treatments
- Long-Term Effects of COVID-19
- Sleep and related disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Digital Mental Health Interventions
- Treatment of Major Depression
- Mental Health Treatment and Access
- Adolescent and Pediatric Healthcare
- Gut microbiota and health
- Sleep and Wakefulness Research
- Gastroesophageal reflux and treatments
- Epigenetics and DNA Methylation
- Pharmaceutical Practices and Patient Outcomes
- Genetics and Neurodevelopmental Disorders
Universidad de Oviedo
2013-2025
Instituto de Investigación Sanitaria del Principado de Asturias
2019-2025
Centro de Investigación Biomédica en Red de Salud Mental
2016-2025
Centro de Investigación Biomédica en Red
2019-2025
Gobierno del Principado de Asturias
2014-2024
Instituto de Salud Carlos III
2020-2024
Centre for Biomedical Network Research on Rare Diseases
2020-2023
Hospital Clínic de Barcelona
2022
Central University Hospital of Asturias
2021
Research Network (United States)
2020
Epidemic outbreaks have significant impact on psychological well-being, increasing psychiatric morbidity among the population. We aimed to describe early of COVID-19 and its contributing factors in a large Spanish sample, globally according mental status (never disorder NMD, past PMD, current CMD).An online questionnaire was conducted between 19 26 March, five days after official declaration alarm lockdown order. Data included sociodemographic clinical information DASS-21 IES questionnaires....
Abstract Background and Hypothesis A pro-inflammatory phenotype has been related to psychotic disorders. The neutrophil-lymphocyte ratio (NLR) is an accessible biomarker that could be helpful characterize this systemic inflammation state. Study Design This study evaluated the NLR in a cohort of 310 subjects with first episode psychosis (FEP) matched group 215 healthy controls, recruited 16 Spanish centers participating PEPs Project. We investigated measures over 2 years prospective,...
Immune-inflammatory processes have been implicated in schizophrenia (SCH), but their specificity is not clear.To identify potential differential intra-/intercellular biochemical pathways controlling immune-inflammatory response and oxidative-nitrosative impact on SCH patients, compared with bipolar disorder (BD) patients healthy controls (HC).Cross-sectional, naturalistic study of a cohort (n=123) [BD (n=102) HC (n=80)].ANCOVA (or Quade test) for age gender when comparing the three groups,...
Abstract To assess the role of age (early onset psychosis-EOP < 18 years vs. adult psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD bipolar disorders-BD) on duration untreated psychosis (DUP) prodromal symptoms in a sample patients with first episode psychosis. 331 (7–35 old) were recruited 174 (52.6%) diagnosed SSD or BD at one-year follow-up through multicenter longitudinal study. The Symptom Onset Schizophrenia (SOS) inventory, Positive Negative Syndrome Scale...
Lithium (Li) is the first-line treatment for bipolar disorder (BD) even though only 30 % of BD patients are considered excellent responders. The mechanisms by which Li exerts its action not clearly understood, but it has been suggested that specific epigenetic mechanisms, such as methylation processes, may play a role. In this regard, DNA patterns can be used to estimate age (EpiAge), accelerated in and reversed treatment. Our first aim was compare profile peripheral blood between...
Suicide is the leading cause of non-natural death worldwide, and major depressive disorder (MDD) mood with highest prevalence among individuals suicidal behaviour (SB). The role inflammation immunomodulation in disorders has raised interest recent years, as biomarkers have been reported to be increased patients, suggesting a their pathogenesis. influence on haematopoietic production well known; however, comprehensive study patients episodes (MDE) lacking. We examined global parameters from...
Introduction Coronavirus disease 2019 (COVID-19) forced Spain to implement unprecedented lockdown restriction. In this context, different factors could worsen sleep quality, but the impact of pandemic and on is still mostly unknown. cross-sectional study, we describe self-reported disturbances in people without mental health disorders from a large Spanish sample (n = 15,070).
The Positive and Negative Syndrome Scale (PANSS) is the most widely used rating scale to assess psychotic symptoms in patients with schizophrenia other primary psychoses. However, a definitive consensus regarding its dimensional structure remains elusive. present work aims determine number of dimensions through network analysis approach sample individuals experiencing first-episode spectrum disorder (FE-SSD) minimal or no prior exposure antipsychotic treatment. Baseline data 446 participants...
Smoking and depression are related in a bidirectional way: smoking is the primary avoidable cause of illness death patients with depression, one most consistent risk factors for smoking. The main objective this study to investigate relationship between analyzing sociodemographic clinical variables such as severity symptoms, subtype affective disorder, its impact on suicidal behavior population. A sample 201 patients, over 18 years age [mean (SD) = 53.76 (10.36) years; women 132 (65.7%)],...
Recent diffusion imaging studies using free-water (FW) elimination have shown increased FW in gray matter (GM) and white (WM) first-episode psychosis (FEP) lower corrected fractional anisotropy (FAt) WM chronic schizophrenia. However, little is known about the longitudinal stability clinical significance of these findings. To determine tissue-specific FAt abnormalities FEP, as part a multicenter Spanish study, 132 FEP 108 healthy controls (HC) were clinically characterized underwent...