A5068399437- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Mental Health and Psychiatry
- Digital Mental Health Interventions
- Neurological disorders and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Obsessive-Compulsive Spectrum Disorders
- Advanced Neuroimaging Techniques and Applications
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Genetic Neurodegenerative Diseases
- Psychosomatic Disorders and Their Treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Music Perception
- Electroconvulsive Therapy Studies
- Autism Spectrum Disorder Research
- Personality Disorders and Psychopathology
- Family Caregiving in Mental Illness
- Mobile Health and mHealth Applications
- Diet and metabolism studies
- Attention Deficit Hyperactivity Disorder
- Mental Health Treatment and Access
Centro de Investigación Biomédica en Red de Salud Mental
2015-2024
Instituto de Salud Carlos III
2023-2024
Hospital de Sant Pau
2015-2024
Universitat de Vic - Universitat Central de Catalunya
2023-2024
Spanish Clinical Research Network
2022-2024
Universitat Autònoma de Barcelona
2014-2023
Hospital Universitari de Vic
2023
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2022
Universitat de Barcelona
2015-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2022
Abstract Background Social cognition has been associated with functional outcome in patients first episode psychosis (FEP). also neurocognition and cognitive reserve. Although reserve, neurocognitive functioning, social cognition, are related, the direction of their associations is not clear. Therefore, main aim this study was to analyze influence as a mediator between reserve domains on functioning FEP both at baseline 2 years. Methods The sample composed 282 followed up for To whether...
Cognitive reserve (CR) refers to the brain's capacity cope with pathology in order minimize symptoms. CR is associated different outcomes severe mental illness. This study aimed analyze impact of according diagnosis first-episode affective or non-affective psychosis (FEP).A total 247 FEP patients (211 and 36 affective) 205 healthy controls were enrolled. To assess CR, common proxies have been integrated (premorbid IQ; education-occupation; leisure activities). The groups divided into high...
Background Aims were to assess the efficacy of metacognitive training (MCT) in people with a recent onset psychosis terms symptoms as primary outcome and variables secondary outcome. Method A multicenter, randomized, controlled clinical trial was performed. total 126 patients randomized an MCT or psycho-educational intervention cognitive-behavioral elements. The sample composed psychosis, recruited from nine public centers Spain. treatment consisted eight weekly sessions for both groups....
BackgroundUp to 30% of patients with schizophrenia are resistant antipsychotic drug treatment, 60% such cases also failing respond clozapine. Deep brain stimulation (DBS) has been used in treatment other psychiatric disorders, but there is a lack trials schizophrenia, partly due uncertainties over where site the electrodes. This trial aimed examine effectiveness nucleus accumbens (NAcc) and subgenual anterior cingulate cortex (subgenual ACC) targeted DBS; primary outcome measure was PANSS...
The thalamus is a subcortical structure formed by different nuclei that relay information to the neocortex. Several reports have already described alterations of this in patients schizophrenia experience auditory hallucinations. However, date no study has addressed whether volumes specific thalamic are altered chronic experiencing persistent We processed structural MRI images using Freesurfer, and segmented them into 25 probabilistic atlas developed Iglesias collaborators (Iglesias et al.,...
Abstract Background Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have deleterious effect on cognitive performance remains under debate. We aim investigate whether anticholinergic loadings and dose AP drugs first episode psychosis (FEP) advanced phase remission associated with impairment differences between premorbid intellectual quotient (IQ) subgroups. Methods Two hundred sixty-six patients participated. The primary...
Gene-environment (GxE) interactions have been related to psychosis spectrum disorders, involving multiple common genetic variants in genes with very small effect sizes, and several environmental factors that constitute a dense network of exposures named the exposome. Here, we aimed analyze GxE cohort 310 first-episode psychotic (FEP) 236 healthy controls, by using aggregate scores estimated large populations such as polygenic risk score for schizophrenia (PRS-SCZ) Maudsley (ERS). In contrast...
The extreme variability in symptom presentation reveals that individuals diagnosed with a first-episode psychosis (FEP) may encompass different sub-populations potentially illness courses and, hence, treatment needs. Previous studies have shown sociodemographic and family environment factors are associated more unfavorable trajectories. aim of this study was to examine the dimensional structure symptoms identify individuals' trajectories at early stage potential risk poor outcomes follow-up...
Abstract Objective The period immediately after the onset of first‐episode psychosis (FEP) may present with high risk for suicidal ideation (SI) and attempts, although this differ among patients. Thus, we aimed to identify trajectories SI in a 2‐years follow‐up FEP cohort assess baseline predictors clinical/functional evolution each trajectory SI. Methods We included 334 participants data on Growth mixture modeling was used Putative sociodemographic, clinical, cognitive distinct were...
Abstract To assess the role of age (early onset psychosis-EOP < 18 years vs. adult psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD bipolar disorders-BD) on duration untreated psychosis (DUP) prodromal symptoms in a sample patients with first episode psychosis. 331 (7–35 old) were recruited 174 (52.6%) diagnosed SSD or BD at one-year follow-up through multicenter longitudinal study. The Symptom Onset Schizophrenia (SOS) inventory, Positive Negative Syndrome Scale...
Different lines of evidence indicate that the structure and physiology basal ganglia thalamus is disturbed in schizophrenia. However, it unknown whether volume shape these subcortical structures are affected schizophrenia with auditory hallucinations (AH), a core positive symptom disorder. We took structural MRI from 63 patients schizophrenia, including 36 AH 27 who had never experienced (NAH), 51 matched healthy controls. extracted volumes for left right thalamus, globus pallidus, putamen,...
The characterization of the first episode psychosis and how it should be treated are principal issues in actual research. Realistic, naturalistic studies necessary to represent entire population attended daily practice.Sixteen participating centers from PEPs project recruited 335 patients, aged 7 35 years. This article describes discusses psychopharmacological interventions safety profiles at baseline during a 60-day pharmacovigilance period.The majority patients received second-generation...