A5066437036- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Schizophrenia research and treatment
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Genetics and Neurodevelopmental Disorders
- Protein Kinase Regulation and GTPase Signaling
- Psychedelics and Drug Studies
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Phosphodiesterase function and regulation
- Nuclear Receptors and Signaling
- Protein Tyrosine Phosphatases
- Family Caregiving in Mental Illness
- Cell death mechanisms and regulation
- Treatment of Major Depression
- Diet and metabolism studies
- Advanced machining processes and optimization
- Bipolar Disorder and Treatment
- Pain Mechanisms and Treatments
- Macrophage Migration Inhibitory Factor
Centro de Investigación Biomédica en Red
2019-2025
University of the Basque Country
2010-2025
Centro de Investigación Biomédica en Red de Salud Mental
2010-2025
Instituto de Salud Carlos III
2023-2025
BioCruces Health research Institute
2016-2024
Universitat de Barcelona
2023
University of Bath
2013
Virginia Commonwealth University
2013
University of Bristol
2010-2013
Universitat de les Illes Balears
2008
We have compared the ability of a number μ-opioid receptor (MOPr) ligands to activate G proteins with their abilities induce MOPr phosphorylation, promote association arrestin-3 and cause internalization. For model protein-coupled (GPCR) activation where all agonists stabilize single active conformation receptor, close correlation between signaling outputs might be expected. Our results show that overall there is very good efficacy for protein recruitment, whereas few agonists, in particular...
It remains unexplored in the field of fear memory whether functional neuronal connectivity between two brain areas is necessary for one sex but not other. Here, we show that chemogenetic silencing centromedial (CeM)-
Previously we correlated the efficacy for G protein activation with that arrestin recruitment a number of agonists at μ-opioid receptor (MOPr) stably expressed in HEK293 cells. We suggested endomorphins (endomorphin-1 and -2) might be biased toward recruitment. In present study, investigated this phenomenon more detail endomorphin-2, using endogenous MOPr rat brain as well For neurons brainstem locus ceruleus slices, peptide...
Susceptibility to schizophrenia is determined by interactions between genes and environment, possibly via epigenetic mechanisms. Schizophrenia has been associated with a restrictive epigenome, histone deacetylase (HDAC) inhibitors have postulated as coadjuvant agents potentiate the efficacy of current antipsychotic drugs. We aimed evaluate global posttranslational modifications (HPTMs) HDAC expression activity in dorsolateral prefrontal cortex (DLPFC) individuals schizophrenia.
Abstract Postsynaptic α 2A -adrenoceptor density is enhanced in the dorsolateral prefrontal cortex (DLPFC) of antipsychotic-treated schizophrenia subjects. This alteration might be due to transcriptional activation, and could regulated by epigenetic mechanisms such as histone posttranslational modifications (PTMs). The aim this study was evaluate ADRA2A ADRA2C gene expression (codifying for 2 subtypes), permissive repressive PTMs at promoter regions DLPFC subjects with matched controls ( n =...
Consumption of ethanol is a considerable risk factor for death in heroin overdose. We sought to determine whether mildly intoxicating concentration could alter morphine tolerance at the cellular level. In rat locus coeruleus (LC) neurons, was reversed by acute exposure brain slice (20 mM). Tolerance opioid peptide [d-Ala<sup>2</sup>,<i>N</i>-MePhe<sup>4</sup>,Gly-ol]-enkephalin not ethanol. Previous studies LC neurons have revealed role protein kinase C (PKC)<i>α</i> <i>μ</i>-opioid receptor...
Abstract The status of serotonin 5HT 2A receptors (5HT Rs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and vitro post-mortem binding studies have reported conflicting results about R density. Radiotracers bind different receptor conformations depending on their agonist, antagonist or inverse agonist properties. This study investigates density the prefrontal cortex from subjects with controls using three radiotracers a pharmacological profile....
Abstract Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu 2 R and 3 R) in brains schizophrenia patients may explain the limited efficacy 2/3 ligands clinical trials. Studies evaluating levels well-designed, large postmortem brain cohorts are needed to address this issue. Postmortem samples from dorsolateral prefrontal cortex 96 subjects matched controls were collected. Toxicological analyses identified cases who (AP+) or not (AP-) receiving...
Objectives α2C-adrenoceptors (α2C-AR) are involved in behavioural responses relevant to psychiatric disorders and suicide completion. The genetic polymorphism α2CDel322-325-AR confers a loss-of-function phenotype. Functional human studies have associated with major depression pathophysiology. aim of this study was analyse, for the first time, association completion related disorders: depression, schizophrenia, opiate alcohol abuse dependence. Methods Post-mortem brain DNA extracted (n = 516)...
Abstract Treatment-resistant schizophrenia (TRS) is defined as the absence of symptomatic response to two different adequately administered antipsychotic drugs other than clozapine, which most effective drug in these patients. Gene expression profiling studies could be a valuable tool identifying specific genes and pathways involved mechanism action leading better understanding molecular biology underlying TRS. We analyzed gene co-expression modules (clusters with highly correlated...