A5040934732- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug-Induced Adverse Reactions
- IL-33, ST2, and ILC Pathways
- PI3K/AKT/mTOR signaling in cancer
- Mast cells and histamine
- Pharmacovigilance and Adverse Drug Reactions
- Genetic Associations and Epidemiology
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Immune Cell Function and Interaction
- Treatment of Major Depression
- Inhalation and Respiratory Drug Delivery
- Hemophilia Treatment and Research
- Biomedical and Chemical Research
- Eosinophilic Esophagitis
- Urticaria and Related Conditions
- Dermatological diseases and infestations
- Pharmaceutical studies and practices
- Lichen and fungal ecology
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Disorders and Syndromes
Hospital Universitario Nuestra Señora de Candelaria
2012-2025
Universidad de La Laguna
2019-2021
University of Salzburg
2010
Promotora de Informaciones (Spain)
2004
ALK-Abelló (Spain)
2001
Summary Background There are few studies comparing the sensitization with mite allergens from different species which could potentially be cause of allergy. Objective To improve diagnosis allergic patients a diverse territory in D. pteronyssinus / farinae mites together storage present environment. Methods Four hundred and seventy‐seven (both children adults) regions, covering main prevalent areas Spain, were recruited. sIgE to eight was measured SPT whole extracts, level allergen exposure,...
Background and Objectives: One of the most common causes drug-induced angioedema (AE-DI) is related to reduced bradykinin breakdown after use certain medications. This case for forms AE-DI due angiotensin-converting enzyme inhibitors (ACEi), which are used treatment cardiovascular conditions. The AE not clear in these patients. Given limited number AE-ACEi genetic loci identified by genome-wide association studies, we opted assess utility NGS a panel relevant genes identify candidate risk...
<i>Background:</i> Polymerised allergenic extracts (allergoids) are commonly used in allergen immunotherapy. Clinical efficacy and safety of these have been demonstrated. Recently, sequences identified by mass spectrometry depigmented polymerised (Dpg-Pol) extracts. The objectives this study were to investigate the presence allergens Dpg-Pol house dust mite analyze immunological changes induced asthmatic patients enrolled a double-blind, placebo-controlled study....
Background Before the advent of genome-wide association studies (GWAS), ADAM33, ADRB2, CD14, MS4A2 (alias FCER1B), IL13, IL4, IL4R, and TNF constituted most replicated non-HLA candidate genes with asthma related traits. However, except for IL13-IL4 region, none these have been found in close proximity significant hits among GWAS or Here we aimed to assess reproducibility associations test if were more evident considering effect age at diagnosis. Methodology/Principal Findings We...
Summary Background Most published studies on changes of specific IgG or its subclasses as a response to stimuli by allergens have been performed patients under immunotherapy. There are few reports analysing the immunoglobulins in exposed their natural habitats. Objective The aim this work was discover history Apis (IgG‐ap) and IgG4 (IgG4‐ap) levels beekeepers from Canary Islands. Methods We studied 242 (Bks). used questionnaire measured total IgE seric (IgE‐ap), IgG‐ap IgG4‐ap against...
Background Hereditary angioedema is a rare genetic condition caused by C1 esterase inhibitor deficiency, dysfunction, or kinin cascade dysregulation, leading to an increased bradykinin plasma concentration. poorly recognized clinical entity and very often misdiagnosed as histaminergic angioedema. Despite its nature, first-line screening not integrated in routine diagnosis. Consequently, delay the diagnosis, inaccurate incomplete diagnosis treatment of hereditary are common. Objective In...
García‐Robaina JC, Eraso E, Martínez J, Martinez A, de la Torre Morin F, Hernández‐Nieto L, Pineda‐Algorta Guisantes J. Sensitization to Blomia kulagini in a general population of subtropical region Spain (Canary Islands). Allergy 1997; 52: 727–731. The genus has been described as allergenic man. present study aimed assess the prevalence B. sensitization large allergic subjects without occupational exposure Islands, Spain). Secondarily, new standardized extract was evaluated. comprised 207...
Despite asthma has a considerable genetic component, an important proportion of risks remain unknown, especially for non-European populations. Canary Islanders have the largest African ancestry observed among Southwestern Europeans and highest prevalence in Spain. Here we examined broad chromosomal regions previously associated with excess Islanders, aim identifying novel risk variants susceptibility. In two-stage cases-control study, revealed variant within HLA-DQB1 significantly...
Hereditary angioedema (HAE) is a rare disease where known causes involve C1 inhibitor dysfunction or dysregulation of the kinin cascade. The updated HAE management guidelines recommend performing genetic tests to reach precise diagnosis. Unfortunately, are still uncommon in diagnosis routine. Here, we characterized for first time affected families from Canary Islands (Spain). Whole-exome sequencing data was obtained 41 patients and unaffected relatives 29 unrelated identified archipelago....