A5019350140- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Erythrocyte Function and Pathophysiology
- Medical Malpractice and Liability Issues
- Iron Metabolism and Disorders
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
- Developmental Biology and Gene Regulation
- Elbow and Forearm Trauma Treatment
- Neonatal Health and Biochemistry
- Endoplasmic Reticulum Stress and Disease
- Shoulder and Clavicle Injuries
- Orthopedic Infections and Treatments
- Cardiac Fibrosis and Remodeling
- Clinical Reasoning and Diagnostic Skills
- Connective Tissue Growth Factor Research
- Cancer Cells and Metastasis
Instituto de Biologia Experimental e Tecnológica
2021-2022
Universidade Nova de Lisboa
2021-2022
Instituto Politécnico de Santarém
2015-2018
Instituto Gulbenkian de Ciência
2017-2018
Sepsis is an often lethal syndrome resulting from maladaptive immune and metabolic responses to infection, compromising host homeostasis. Disease tolerance a defense strategy against infection that preserves homeostasis without exerting direct negative impact on pathogens. Here, we demonstrate induction of the iron-sequestering ferritin H chain (FTH) in response polymicrobial infections critical establish disease sepsis. The protective effect FTH exerted via mechanism counters iron-driven...
Background Activated cardiac fibroblasts (CF) play a central role in fibrosis, condition associated with most cardiovascular diseases. Conversion of quiescent into activated CF sustains heart integrity upon injury. However, permanence active state inflicts deleterious function effects. Mechanisms underlying this cell conversion are still not fully disclosed, contributing to limited target space and lack effective anti-fibrotic therapies. Materials methods To prioritize targets for drug...
The Notch-signaling ligand DLL1 has emerged as an important player and promising therapeutic target in breast cancer (BC). DLL1-induced Notch activation promotes tumor cell proliferation, survival, migration, angiogenesis BC stem maintenance. In BC, overexpression is associated with poor prognosis, particularly estrogen receptor-positive (ER+) subtypes. Directed therapy early advanced dramatically changed the natural course of ER+ BC; however, relapse a major clinical issue, new strategies...