A5034991826- Developmental Biology and Gene Regulation
- Cancer Cells and Metastasis
- Malaria Research and Control
- Gut microbiota and health
- Microbial Metabolic Engineering and Bioproduction
- Liver Disease Diagnosis and Treatment
- Graphene and Nanomaterials Applications
- Cancer-related Molecular Pathways
- Calcium signaling and nucleotide metabolism
- Parasites and Host Interactions
- Monoclonal and Polyclonal Antibodies Research
- 14-3-3 protein interactions
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
- Pancreatitis Pathology and Treatment
- Evolution and Genetic Dynamics
- Mosquito-borne diseases and control
- Pharmacological Effects of Natural Compounds
- Histone Deacetylase Inhibitors Research
- Bird parasitology and diseases
- Hemoglobinopathies and Related Disorders
- Electrospun Nanofibers in Biomedical Applications
- Parasite Biology and Host Interactions
- Marine Sponges and Natural Products
- Diet and metabolism studies
Universidade Nova de Lisboa
2017-2022
Instituto de Biologia Experimental e Tecnológica
2017-2021
Instituto Gulbenkian de Ciência
2019-2020
Calouste Gulbenkian Foundation
2019
University of Lisbon
2014-2017
Intracellular pathogens have evolved mechanisms to ensure their survival and development inside host cells. Here, we show that glucose is a pivotal modulator of hepatic infection by the rodent malaria parasite Plasmodium berghei uptake via GLUT1 transporter specifically enhanced in P. berghei-infected We further ATP levels cells containing developing parasites are decreased, which known enhance membrane activity. In addition, molecules translocated cell, increasing at later stages infection....
The first phase of malaria infection occurs in the liver and is clinically silent. Inside hepatocytes each Plasmodium sporozoite replicate into thousands erythrocyte-infectious merozoites that when released blood stream result clinical symptoms disease. time between inoculation appearance parasites defined as pre-patent period, which classically analysed by time-consuming labor-intensive techniques, such microscopy PCR. Luciferase-expressing berghei were used to measure period rodents using...
Breast cancer (BC) is the most common type of in women and has a high rate relapse death. Notch signaling crucial for normal breast development homeostasis. Dysregulation receptors ligands been detected different BC subtypes shown to be implicated tumor development, progression, drug resistance, recurrence. However, effects various types remain poorly understood. In this study, we investigated ligand DLL1 three human cell lines: MCF-7, BT474, MDA-MB-231. We showed that expression higher...
The Notch-signaling ligand DLL1 has emerged as an important player and promising therapeutic target in breast cancer (BC). DLL1-induced Notch activation promotes tumor cell proliferation, survival, migration, angiogenesis BC stem maintenance. In BC, overexpression is associated with poor prognosis, particularly estrogen receptor-positive (ER+) subtypes. Directed therapy early advanced dramatically changed the natural course of ER+ BC; however, relapse a major clinical issue, new strategies...
first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Size: Aa Line Spacing: Column Width: Background: Open AccessAbstract Electrospun Polycaprolactone Fibers Doped with 1-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide and Poly(3,4-ethylenedioxythiophene) for Neural Tissue Engineering † by Nuno Roberto 1, Joana Dias 2, Lya Piaia João P. Borges 1,3 Célia R. Henriques 1,2,* 1 i3N/CENIMAT, NOVA School of Science Technology, University Lisbon, Campus de...
Many microbes colonise the gut establishing interactions with their host and nutritional environment. Studying genetics metabolism brought about drive potential to engineer communities promote health improve industrial processes. However, structuring artificial in predictable ways is underdeveloped. We studied Escherichia coli ’s genetic targets physiological mechanisms during colonisation adaptation how metabolic environment/microbiota complexity shape these introduced a tractable E. K-12...
Members of the gut microbiota are thought to experience strong competition for nutrients. However, how such shapes their evolutionary dynamics and depends on intra- interspecies interactions is poorly known. Here we tested hypothesis that Escherichia coli evolution in mouse more predictable across hosts absence than presence other microbial species. Supporting this hypothesis, observed a specific genetic adaptation lrp, gene encoding global regulator amino acid metabolism, predictably...