A5030703512- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Computational Drug Discovery Methods
- Retinal Development and Disorders
- Cancer, Hypoxia, and Metabolism
- Antibiotic Resistance in Bacteria
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cholinesterase and Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Dietary Effects on Health
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Vitamin D Research Studies
- Biochemical and Molecular Research
- Protease and Inhibitor Mechanisms
- Mitochondrial Function and Pathology
Jouf University
2019-2025
Universiti Putra Malaysia
2020
Centre for DNA Fingerprinting and Diagnostics
2008-2018
University of Alabama at Birmingham
2010-2014
Centre for Cellular and Molecular Biology
2007-2009
Abstract Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence mortality. Natural derivatives are more efficacious in various preclinical models neurodegenerative illnesses. These natural compounds include phytoconstituents herbs, vegetables, fruits, nuts, marine freshwater flora, with remarkable efficacy mitigating neurodegeneration enhancing cognitive abilities models. According latest research,...
MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their mRNA sequences’ 3′ untranslated regions (3′UTR). Interleukin-6 (IL-6) is known promote cancer progression and treatment resistance. In this study, we aimed explore therapeutic effects gold nanoparticles (GNP) against IL-6 overexpression miRNA-26a-5p breast (BC) cells. GNP were synthesized using trisodium citrate method characterized through UV-Vis spectroscopy, dynamic light scattering (DLS),...
ABSTRACT Pathogens frequently employ eukaryotic linear motif (ELM)-rich intrinsically disordered proteins (IDPs) to perturb and hijack host cell networks for a productive infection. Mycobacterium tuberculosis has relatively high percentage of IDPs in its proteome, the significance which is not known. The -specific PE-PPE protein family several members with unusually levels structural disorder disorder-promoting Ala/Gly residues. PPE37 protein, member this family, carries an N-terminal PPE...
Chromium (Cr) is a toxic heavy metal present in industrial effluent which could cause degenerative diseases on ingestion. Therefore, elimination of Cr from contaminated water becomes essential to preserve and sustain the quality life. In this study, superparamagnetic iron oxide nanoparticles (SPIONs) were impregnated activated carbon checked for enhanced removal Cr(VI). Thus, granular (N‐GAC) mesh size 8∗20 was with SPIONs produce (Sp‐GAC) characterized using UV‐VIS spectrophotometer, FT‐IR,...
Background: Mutations in the CYP1B1 gene have been associated with primary congenital glaucoma (PCG), a developmental visual disorder. mutations linked to increased lipid peroxidation and abnormalities trabecular meshwork. In this study, protein modeling was utilized analyze pathogenicity of hotspot Pakistani families PCG.Methods: A comprehensive literature survey conducted identify Patients. Ensemble used missense mutations. 3-D mutants done using I-Tasser. Potential deleterious effects...
Candida albicans (C. albicans) is an opportunistic pathogen in immunocompromised individuals and a normal inhabitant of the oral cavity, throat, gastrointestinal tract, genitourinary system among health populations. Our study focused on identifying new inhibitors capable binding to mutant cytochrome P450 family 51 (CYP-51) protein intended be effective against resistant C. infections. The pharmacophore ligand-based model was used for virtual screening compound libraries. Molecular docking...
Elucidation of the basic mechanistic and biochemical principles underlying siderophore mediated iron uptake in mycobacteria is crucial for targeting this principal survival strategy vis-à-vis virulence determinants pathogen. Although, an understanding biosynthesis known, mechanism their secretion still remains elusive.Here, we demonstrate interplay among three regulated Mycobacterium tuberculosis (M.tb) proteins, namely, Rv1348 (IrtA), Rv1349 (IrtB) Rv2895c export import M.tb siderophores...
Breast cancer (BC) is the most common malignancy in females globally. Matrix metalloproteinase-9 (MMP-9) crucial to invasion, progression and spread of BC. Gold nanoparticles (AuNPs) have an anti-tumorigenic role, but their therapeutic role microRNAs (miRNAs) regulation has not been explored. This study determined potential AuNPs against MMP-9 overexpression/production miRNA-204-5p BC cells.AuNPs were newly engineered, stability was analyzed using zeta potential, polydispersity index,...
Background: D-dimer, generated upon the degradation of fibrin, is extensively used to detect thrombosis in various diseases. It also explored as a marker for cases with COVID-19 disease. Few studies have confirmed its utility assessing disease severity. Objectives: The current research was undertaken determine role D-dimer patients and investigate any association progression severity Saudi population. Methods: Clinical indices were collected from tertiary care hospitals Aljouf Qassim...
Background: Peroxynitrite (ONOO−) is an oxidant linked with several human pathologies. Apigenin, a natural flavonoid known for its health benefits, remains unexplored in relation to ONOO− effects. This study investigated the potential of apigenin structurally protect fibrinogen, essential blood clotting factor, from ONOO−-induced damage. Methods: Multi-approach analyses were carried out where fibrinogen was exposed generation while testing efficacy apigenin. The role against modifications...
Background Mycobacterium tuberculosis (M.tb), the pathogen that causes tuberculosis, is capable of staying asymptomatically in a latent form, persisting for years very low replicating state, before getting reactivated to cause active infection. It therefore important study M.tb chromosome replication, specifically its initiation and regulation. While region between dnaA dnaN gene autonomous little known about interaction DnaA initiator protein, oriC origin replication sequences their...