A5080006976- Natural product bioactivities and synthesis
- Crystallization and Solubility Studies
- Plant biochemistry and biosynthesis
- Phytochemical Studies and Bioactivities
- X-ray Diffraction in Crystallography
- Sesquiterpenes and Asteraceae Studies
- Sulfur-Based Synthesis Techniques
- Bioactive Compounds and Antitumor Agents
- Carbohydrate Chemistry and Synthesis
- Synthesis and Catalytic Reactions
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Phytochemistry and Biological Activities
- Asymmetric Synthesis and Catalysis
- Phytochemistry and Bioactive Compounds
- Synthesis of Indole Derivatives
- Crystallography and molecular interactions
- Porphyrin and Phthalocyanine Chemistry
- Synthesis of heterocyclic compounds
- Photochemistry and Electron Transfer Studies
Polish Academy of Sciences
2014-2024
Institute of Organic Chemistry
2014-2024
National Veterinary Research Institute
2006
Abstract Despite the significant role of pyruvic acid in biotransformations, utilization pyruvates field catalytic asymmetric synthesis has been unexpectedly limited. This statement also applies to enamine catalysis, which seem be challenging substrates. Recently, first illustration addition β‐nitrostyrenes, catalyzed by a NahE enzyme using mechanism, appeared literature. Now, we demonstrate pyrrolidine‐based catalyst can mimick mechanism used this activate structurally diverse nitroalkenes...
Abstract A practical method for the preparation of benzoyl protected allyl and benzyl α‐ D ‐idopyranosides, ‐idopyranosyl trichloroacetimidate, from 1,2,3,4,6‐penta‐ O ‐acetyl‐α‐ ‐idopyranose, is described. All derivatives can be prepared on a multigram scale require only simple chromatographic purification. concise synthesis lupane triterpenes bearing an unusual ‐idopyranoside fragment new compounds were evaluated in vitro their cytotoxic activities. Novel saponins exhibited interesting...
Abstract A concise synthesis of 28a‐homo‐28a‐thiolupane triterpenes and the corresponding saponins containing D ‐mannose, ‐idose, L ‐arabinose ‐rhamnose moieties was elaborated. New were obtained from readily available 3‐ O ‐allylbetulinal by elongation carbon chain Wittig reaction, followed hydrolysis enol ether, reduction elongated aldehyde nucleophilic substitution mesylate with thiocyanate ion. Saponins glycosylation classical Schmidt donors. The cytotoxic activities new homothiolupane...
Triterpene bidesmosides are considered as highly cytotoxic saponins, usually less toxic against normal cells than monodesmosides, and haemolytic. Biological activity of the betulin-type bidesmosides, rarely found in Nature, seldom prepared due to serious synthetic problems, is poorly recognized. We report herein a protocol for preparation disubstituted lupane saponins (betulin bidesmosides) by treatment their benzoates with potassium carbonate dichloromethane / methanol solution....
The rearrangements of dihydrobetulin, dihydrobetulinic acid, and abeo-lupane epoxides under acidic conditions (HCl, montmorillonite K10, BF3·Et2O) were studied. treatment dihydrobetulin with HCl or K10 produced olefins. Their epoxidation afforded epoxides, which, in the presence protic Lewis acids, rearranged to dienes lupanes bearing a bicyclo[3.3.1]nonane fragment. structure final products depended on nature catalyst. promoted 1,4-elimination water, whereas BF3·Et2O bond migration took...
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