A5042497498- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Sesquiterpenes and Asteraceae Studies
- Phytochemical Studies and Bioactivities
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Bioactive Compounds
- Carbohydrate Chemistry and Synthesis
- Chronic Obstructive Pulmonary Disease (COPD) Research
Polish Academy of Sciences
2015-2021
Institute of Organic Chemistry
2016-2021
In search of new cytotoxic derivatives based on the lupane scaffold, seco-lupane azides were coupled with a number alkynes under 1,3-dipolar cycloaddition (CuAAC) conditions to afford 1,2,3-triazoles. Phenylalkynes having different substituents at para position used as starting materials. Similarly, coupling thiocyanate sodium azide gave 5-thiotetrazole. The cytotoxicity thirteen investigated, well effect in phenyl ring activity Limited was observed for some these products. Most studied...
Triterpene bidesmosides are considered as highly cytotoxic saponins, usually less toxic against normal cells than monodesmosides, and haemolytic. Biological activity of the betulin-type bidesmosides, rarely found in Nature, seldom prepared due to serious synthetic problems, is poorly recognized. We report herein a protocol for preparation disubstituted lupane saponins (betulin bidesmosides) by treatment their benzoates with potassium carbonate dichloromethane / methanol solution....
cis-Dihydroxylation of trinor-18α-olean-17(22)-ene 2 with osmium tetroxide led to diol 9. Its cleavage lead tetraacetate gave tetracyclic ketoaldehyde 10. By comparison, the ozonation in presence p-toluenesulfonic acid corresponding ketoacetal 12. Both products were subjected an intramolecular aldol reaction under acidic conditions and yielded unusual triterpenes bearing a bicyclo[4.3.1]decane fragment (22). Further manipulation protective groups afforded compounds useful triterpene...