A5078793045- Natural product bioactivities and synthesis
- Cholinesterase and Neurodegenerative Diseases
- Bioactive Compounds and Antitumor Agents
- Molecular spectroscopy and chirality
- Computational Drug Discovery Methods
- Synthesis and Biological Activity
- Marine Sponges and Natural Products
- Synthesis and biological activity
- Axial and Atropisomeric Chirality Synthesis
- Carbohydrate Chemistry and Synthesis
- Sesquiterpenes and Asteraceae Studies
- Glycosylation and Glycoproteins Research
- Fermentation and Sensory Analysis
- Synthesis and Properties of Aromatic Compounds
- Histone Deacetylase Inhibitors Research
- Sirtuins and Resveratrol in Medicine
- Horticultural and Viticultural Research
- Inflammatory mediators and NSAID effects
- Morinda citrifolia extract uses
- Cancer, Hypoxia, and Metabolism
- Phytochemistry and Biological Activities
- Metal complexes synthesis and properties
- Plant biochemistry and biosynthesis
- Synthesis and Catalytic Reactions
- Chemical synthesis and alkaloids
Palacký University Olomouc
2020-2024
Czech Academy of Sciences, Institute of Experimental Botany
2014-2024
Six new (1, 2, 6, 8, 13, and 20) twenty previously isolated (3-5, 7, 9-12, 14-19, 21-26) steroids featuring thirteen different carbocycle motifs were from the organic extract of soft coral Sinularia polydactyla collected Hurghada reef in Red Sea. The structures relative configurations natural products have been determined based on extensive analysis their NMR MS data. cytotoxic, anti-inflammatory, anti-angiogenic, neuroprotective activity compounds 3-7, 14-20, 22-26, as well effect androgen...
Stilbenes contained in various foods are associated with health beneficial effects. In this study six natural and one synthetic stilbene were tested for their potential to regulate the activity of lipoxygenase cyclooxygenase vitro. The most potent inhibitor 5-lipoxygenase was pterostilbene (IC50 = 9.32 μM), whereas strongest cyclooxygenase-1 cyclooxygenase-2 pinostilbene (IC50s 1.90 0.35 μM, respectively). Pterostilbene 11.70 27.04 μM cyclooxygenase-2, respectively) oxyresveratrol 18.49;...
In search of new cytotoxic derivatives based on the lupane scaffold, seco-lupane azides were coupled with a number alkynes under 1,3-dipolar cycloaddition (CuAAC) conditions to afford 1,2,3-triazoles. Phenylalkynes having different substituents at para position used as starting materials. Similarly, coupling thiocyanate sodium azide gave 5-thiotetrazole. The cytotoxicity thirteen investigated, well effect in phenyl ring activity Limited was observed for some these products. Most studied...
The most successful structures showing their antimicrobial, antiviral or cytotoxic effects. Selectivity of effects has been observed.
The aim of the present study was to elucidate effect food additive tert-butylhydroquinone (TBHQ), its metabolite tert-butylbenzoquinone (TBQ), indirect 2,5-di-tert-butylhydroquinone (DTBHQ) and five other structurally related quinones on enzymatic activity cyclooxygenase-1 -2 (COX-1, -2) 5-lipoxygenase (5-LO). In a conducted purified enzymes TBHQ affected neither COX-1 nor COX-2 activity, but inhibited 5-LO in human neutrophils with an IC50 13.5 µM. contrast, DTBHQ regulated as well (IC50 =...
Oleanolic acid is a natural plant adaptogen, and tryptamine psychoactive drug. To compare their effects of with the effect derivatives, fluorotryptamine amides oleanolic were designed synthesized.The target investigated for pharmacological effect, basic supramolecular self-assembly characteristics. Four human cancer cell lines involved in screening tests performed by standard methods.The ability to display cytotoxicity cause selective apoptosis cervical carcinoma malignant melanoma was seen...
Over the last decades, soft corals have been proven a rich source of biologically active compounds, featuring wide range chemical structures. Herein, we investigated chemistry an alcyonarian genus Lemnalia (Neptheidae), specimens which were collected from coral reefs near Al Lith, on south-west coast Saudi Arabia. A series chromatographic separations led to isolation 31 sesquiterpenes, mainly nardosinane and neolemnane carbon skeletons, among three (13, 14 28) are new natural products. The...
A novel group of 5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline was prepared via microwave assisted one-pot telescopic approach. The synthetic sequence involves the formation amine precursor imidazo[1,2-a] pyridine condensation and reduction under irradiation. Subsequently, Pictet-Spengler cyclization reaction occurs with ketones (cyclic or acyclic) to obtain substituted 5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinolines in excellent yields. Subsequently compounds were tested as...
Benzimidazoles are frequently used in medicinal chemistry. Their anticancer effect is among the most prominent biological activities exhibited by this scaffold. Although numerous benzimidazole derivatives have been synthesized, possible atropisomerism of
Abstract A library of 3‐aryl‐3‐azetidinyl acetic acid methyl ester derivatives was prepared from N ‐Boc‐3‐azetidinone employing the Horner‐Wadsworth‐Emmons reaction, rhodium(I)‐catalyzed conjugate addition arylboronic acids, and subsequent elaborations to obtain ‐unprotected hydrochlorides, ‐alkylated ‐acylated azetidine derivatives. The compounds were evaluated for acetylcholinesterase (AChE) butyrylcholinesterase (BChE) inhibitory activity, revealing several possess AChE inhibition...