A5059786492- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Phytochemicals and Medicinal Plants
- Cholinesterase and Neurodegenerative Diseases
- Click Chemistry and Applications
- Diverse Scientific Research Studies
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Microwave-Assisted Synthesis and Applications
- Neuroscience and Neuropharmacology Research
- Chemical synthesis and alkaloids
- Chemical Synthesis and Analysis
- Synthesis and Reactivity of Heterocycles
Vellore Institute of Technology University
2020-2024
The recent emergence of novel coronavirus (SARS-CoV-2) has been a major threat to human society, as the challenge finding suitable drug or vaccine is not met till date. With increasing morbidity and mortality, need for candidates under great demand. investigations are progressing towards COVID-19 therapeutics. Among various strategies employed, use repurposed drugs competing along with inventions. Based on therapeutic significance, chemical constituents from extract Tinospora cordifolia...
Deep eutectic solvent (DES) catalyzed, Microwave-assisted one-pot conjugate Michael addition followed by annulation of nucleophiles, 4-hydroxy coumarin, 1,3-diketone with α,β-unsaturated carbonyl compounds (chalcones) toward benzopyran, pyranocoumarin, xanthene, dihydrofuran, 4-hydroxy-coumarin (warfarin analogs) derivatives has been achieved. It is a one-pot, solvent, metal-free, and green chemical approach clean reaction pathway, in high regio, stereo selectivities, yields under milder...
Abstract The recent emergence of novel coronavirus (SARS-CoV-2) has been a major threat to human society, as the challenge finding suitable drug or vaccine is not met till date. With increasing morbidity and mortality, need for candidates under great demand. investigations are progressing towards COVID-19 therapeutics among various strategies employed, use repurposed drugs competing along with inventions [1]. Based on therapeutic significance, chemical constituents from extract Tinospora...
A novel group of 5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline was prepared via microwave assisted one-pot telescopic approach. The synthetic sequence involves the formation amine precursor imidazo[1,2-a] pyridine condensation and reduction under irradiation. Subsequently, Pictet-Spengler cyclization reaction occurs with ketones (cyclic or acyclic) to obtain substituted 5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinolines in excellent yields. Subsequently compounds were tested as...
Abstract: Microwaves have been used to produce a practical, high-yielding, and scalable synthesis method for producing disubstituted 2H-indazoles. With this technique, large class of 2H-indazoles can be effectively produced from substituted 2-bromobenzaldehyde, aromatic amine NaN3 using [Cu(phen)(PPh3)2]NO3 as catalysts. outstanding purity yields, the current one-pot synthetic sequence enables addition two structural diversity points broaden chemical space.