With an alarming increase in the number of cancer patients and a variety tumors, it is high time for intensive investigation on more efficient potent anti-tumor agents. Though numerous agents have enriched literature, still there exist challenges, with availability different targets possible cross-reactivity. Herein we chosen phosphoinositide 3-kinase (PI3K) as target interest investigated potential pyrido fused imidazo[4,5- c ]quinoline derivatives to bind strongly active site, thereby...

An expeditious catalyst-free heteroannulation reaction for imidazo[1,2-a]pyridines/pyrimidines/pyrazines was developed in green solvent under microwave irradiation. Using H2O-IPA as the medium, various substituted 2-aminopyridines/pyrazines/pyrimidines underwent annulation with α-bromoketones irradiation to provide corresponding excellent yields. The synthetic methodology appears be very simple and superior already reported procedures high abundance of commercial reagents great ability...

The recent emergence of novel coronavirus (SARS-CoV-2) has been a major threat to human society, as the challenge finding suitable drug or vaccine is not met till date. With increasing morbidity and mortality, need for candidates under great demand. investigations are progressing towards COVID-19 therapeutics. Among various strategies employed, use repurposed drugs competing along with inventions. Based on therapeutic significance, chemical constituents from extract Tinospora cordifolia...

On treatment of copper(II) acetate with aryl hydrazone ligands, four new solid derivatives were produced in appreciable yields. Various characterization techniques including infrared, UV–visible, NMR, electron paramagnetic resonance and mass spectroscopies, elemental analysis, scanning microscopy, powder X‐ray diffraction thermogravimetric analysis revealed a tetra‐coordination all the mononuclear crystalline complexes high thermal stability. Further, significant interaction these novel calf...

Abstract A couple of heteroleptic copper(II) complexes, [Cu( HL 1 )(bpy)](NO 3 ) 2 .2H O (4 a) and [Cu ( )(phen)](NO b) , where is 2‐((benzo[d]thiazol‐2‐ylimino)methyl) phenol, bpy= 2,2′‐bipyridyl phen 1,10‐phenanthroline have been synthesized characterized by elemental analysis, UV/Vis, FTIR, NMR spectroscopic mass spectrometric techniques. The binding interaction metal complexes with ct‐DNA was assessed electronic absorption, fluorescence spectroscopy docking studies. studies reveal that...

Abstract Tuberculosis is one of the most life‐threatening acute infectious diseases diagnosed in humans. In present investigation, a series 16 new disubstituted 1,3‐thiazetidines derivatives designed, and investigated via various silico methods for their potential as anti‐tubercular agent by evaluating ability to block active site PrpR transcription factor protein Mycobacterium tuberculosis . The efficacy molecules was initially assessed with help AutoDock Vina algorithm. Further Glide...

Spin-reorientation transitions in (Pr1−xRx)Co5+δ, where R=Sm, Gd, Tb, Dy, Ho, and Er were determined by ac susceptibility measurements. The spin-reorientation temperature TSR of PrCo5 decreases from 105 K to lower temperatures when Pr is partially replaced Sm, or Er. This decrease arises different causes: the (Pr1−xGdx)Co5 results dilution nonaxial anisotropy on sublattice, while (Pr1−xSmx)Co5 (Pr1−xErx)Co5+δ due positive second-order Stevens coefficients Sm which yield uniaxial...

A series of metallo-organic complexes Al(III), [(CH3COCHCOCH3)2Al(OR)]2 [where R = o-MeC6H4 (1), m-MeC6H4 (2), p-MeC6H4 (3), C6H5CH2 (4), o-ClC6H4CH2 (5), m-ClC6H4CH2 (6), and p-ClC6H4CH2 (7), were synthesized quantitatively by treating Al(OPri)3 with CH3COCH2COCH3 the phenols (o-MeC6H4OH, m-MeC6H4OH, p-MeC6H4OH) concerned as well phenylmethanols (C6H5CH2OH, o-ClC6H4CH2OH, m-ClC6H4CH2OH, p-ClC6H4CH2OH) in suitable stoichiometry using benzene solvent. All these soluble common organic...

Abstract The recent emergence of novel coronavirus (SARS-CoV-2) has been a major threat to human society, as the challenge finding suitable drug or vaccine is not met till date. With increasing morbidity and mortality, need for candidates under great demand. investigations are progressing towards COVID-19 therapeutics among various strategies employed, use repurposed drugs competing along with inventions [1]. Based on therapeutic significance, chemical constituents from extract Tinospora...

Novel structural arrangements for alkoxyalkanol modified titanium tetraisopropoxide [(Ti(OPr i ) 4 , TPT] were obtained from stoichiometric reactions between TPT and alkoxyalkanols {HOCH 2 CH OR,where R= Me, Et}. All the 1:1, 1:2, 1:3 1:4 in refluxing benzene form mononuclear species [(OPr 4-n Ti(OC H OR) n ]. these compounds can be purified by distillation under reduced pressure. On basis of IR NMR ( 1 & 13 C) spectral studies all derivatives have been tetrahedral geometry around atom.

Abstract Benzimidazole compounds are known for their broad spectrum therapeutic potentials. A small library of benzimidazole derivatives were designed and synthesized via a one‐pot telescopic grinding approach. The ability these molecules as proposed anticancer agents evaluated by potential to bind two important cancer pathway protein targets, human estrogen receptors cyclin dependant kinases, 3ERT 5FGK respectively. Further nucleic acid binding reactive oxygen species (ROS) scavenging...