A5004732960- Estrogen and related hormone effects
- 14-3-3 protein interactions
- Viral-associated cancers and disorders
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Electrospun Nanofibers in Biomedical Applications
- HER2/EGFR in Cancer Research
- Histone Deacetylase Inhibitors Research
- PARP inhibition in cancer therapy
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Hair Growth and Disorders
- Phytoestrogen effects and research
- Monoclonal and Polyclonal Antibodies Research
- Folate and B Vitamins Research
- Mechanisms of cancer metastasis
- Natural product bioactivities and synthesis
- Peroxisome Proliferator-Activated Receptors
- Endoplasmic Reticulum Stress and Disease
- Phytochemical Studies and Bioactivities
- Autophagy in Disease and Therapy
- Cancer Treatment and Pharmacology
- NF-κB Signaling Pathways
Palacký University Olomouc
2007-2023
Institute of Molecular and Translational Medicine
2010-2023
John Wiley & Sons (United States)
2019
Hudson Institute
2019
University Hospital Olomouc
2017
Background Castration‐resistant prostate cancer (PCa) represents a serious health challenge. Based on mechanistically‐supported rationale we explored new therapeutic options based clinically available drugs with anticancer effects, including inhibitors of PARP1 enzyme (PARPi), and histone deacetylases (vorinostat), respectively, disulfiram (DSF, known as alcohol‐abuse drug Antabuse) its copper‐chelating metabolite CuET that inhibit protein turnover. Methods Drugs their combination ionizing...
Background: Trichofolliculomas and trichoepitheliomas are benign skin neoplasms originating from hair follicle cells. They result defects in the signaling pathways that regulate morphogenesis regeneration. Thus they seem to be an excellent model of these processes. It is known E-cadherin/β-catenin system adhesion molecules plays a crucial role maintenance tissue architecture. Aim: The aim present study was investigate their involvement tumor development. Methods: Semiquantitative intensity...
Fibrates are widely used hypolipidemic drugs, which serve as ligand of peroxisome proliferator-activated receptor α (PPARα). Recently, they have also been considered potential anticancer agents. We studied effect fibrates treatment on cell proliferation, expression CYP2J2 and concomitant changes in cycle regulatory proteins three different human lines: HEK293, HepG2, HT-29.We WST-1 viability test, western blot immunocytochemistry for detection interests analysis cycle.Our results showed that...
Background: Lymphoproliferative disease often presents the clinician and pathologist with a diagnostic dilemma, particularly in early course of disease. Methods: We used modified BIOMED-2 protocols to detect monoclonal expansions immunoglobulin heavy chain (IgH) T-cell receptor (TCR) genes 957 formalin-fixed paraffin-embedded samples from 717 patients. To eliminate false-positive results, heteroduplex analysis was after PCR reactions. The impact different fixatives on DNA quality performance...