A5026986566- Vestibular and auditory disorders
- Tryptophan and brain disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Immune Cell Function and Interaction
- Nutrition, Genetics, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ear Surgery and Otitis Media
- COVID-19 Clinical Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Neuroscience of respiration and sleep
- GDF15 and Related Biomarkers
- S100 Proteins and Annexins
- COVID-19 Pandemic Impacts
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Adrenal and Paraganglionic Tumors
- Dysphagia Assessment and Management
- Immunodeficiency and Autoimmune Disorders
- Neurological and metabolic disorders
University of Pavia
1996-2024
Azienda di Servizi alla Persona di Pavia (Italy)
2023
ASST Fatebenefratelli Sacco
2018
University of Milan
2001-2006
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2006
Ospedale Maggiore
2002-2006
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2002-2006
IRCCS Istituto Auxologico Italiano
2002-2006
Ospedale degli Infermi
2002
Pendred's syndrome is a combination of congenital sensorineural hearing loss and iodine organification defect leading to positive perchlorate test goiter. Although it the commonest form syndromic loss, variable clinical presentation contributes difficulty in securing diagnosis. The identification disease gene (PDS) prompts need reevaluate identify possible clues for To this purpose, three Italian families presenting with features syndrome, molecular analysis was accompanied by full clinical,...
Mutations in the thyroid peroxidase (TPO) gene lead to severe congenital hypothyroidism due total iodide organification defect (TIOD). According recessive mode of inheritance, patients are homozygous or compound heterozygous for mutations. However, about 17% cases with typical phenotype harbor a single TPO-mutated allele. We present TIOD family which three affected siblings had genomic TPO mutation (R693W) inherited from unaffected father. Other mutations were not found, although all coding...
We studied the potential role of innovative diagnostic tools for management patients with differentiated thyroid cancer (DTC). Several methods detection tumor marker thyroglobulin (Tg) have been employed in 36 apparent remission at moment study. All had negative anti-Tg antibodies and were evaluated during l-T4 suppressive therapy before after stimulation recombinant human TSH (rhTSH). Serum Tg was measured by means conventional [nonhighly sensitive (nhs)] or highly (hs) immunoassays...
SummaryBackground & aimsTo investigate the association between parameters used in nutritional screening assessment (body mass index [BMI], unintentional weight loss [WL] and reduced food intake) clinical outcomes non-critically ill, hospitalized coronavirus disease 2019 (COVID-19) patients.MethodsThis was a prospective multicenter real-life study carried out during first pandemic wave 11 Italian Hospitals. In total, 1391 patients were included. The primary end-point composite of in-hospital...
Summary background Occurrence in a familial setting is well established for medullary thyroid carcinoma (MTC) and has been more recently reported papillary cancer (PTC). Germline mutations or rearrangements of the RET proto‐oncogene are genetic majority hereditary MTCs about 25–40% PTCs. patients A large multigenerational (FMTC) family, comprised four generations total 60 subjects, fully evaluated. Studies on germline polymorphisms, somatic activation haplotyping with ‐linked markers, were...
Background: Malfunction of the SLC26A4 protein leads to prelingual deafness often associated with mild thyroid dysfunction and goiter. It is assumed that acts as a chloride/anion exchanger responsible for iodide organification in gland, conditioning endolymphatic fluid inner ear. Methods: Chloride uptake studies were made using HEK293-Phoenix cells expressing human wild type (pendrin) mutant (SLC26A4S28R) we recently described patient hypothyroidism, goiter sensorineural hearing loss....
Experimental data suggest an involvement of immune cellular components in the development Alzheimer's disease (AD). Against this background, spontaneous natural killer (NK) cell activity and NK-induced cytotoxicity after interleukin-2 (IL-2) were studied healthy elderly subjects patients with dementia Alzheimer type (SDAT) multi-infarct (MID). Higher NK (expressed as total lysis percent increase) at different IL-2 concentrations (50 100 IU/ml/cells) was demonstrated SDAT than (p < 0.001) MID...
Several studies and meta-analyses suggested the role of vitamin D 25OH in preventing severe forms coronavirus disease 2019 (COVID-19). However, evidence on clinical benefits adequacy patients hospitalized for COVID-19 remain conflicting speculative. We aimed to investigate association between serum levels mortality with moderate COVID-19.This prospective observational multicentre study included 361 consecutive admitted Italian hospitals involved NUTRI-COVID19 trial from March August 2020....
Spontaneous natural killer (NK) cell activity and NK-induced cytotoxicity after interferon-γ (IFN-γ) were measured in healthy elderly subjects patients with senile dementia of Alzheimer type (SDAT) multi-infarct (MID). Normal basal IFN-γ-stimulated NK found old MID. On the contrary higher IFN-γ (650 IU) was demonstrated SDAT than MID (p < 0.001). A significant inverse correlation between percent increase Mini Mental State Examination score 0.001) also SDAT. Our data might suggest a...
Former studies have indicated alterations of the cytotoxic activity natural killer (NK) cells in senile dementia Alzheimer type (SDAT). These changes may be related to increased reactivity NK with cytokines, even if an impairment immunosuppressive effect glucocorticoids cannot excluded. In present study we demonstrated a lower cortisol on cytolytic function patients SDAT than healthy elders and multi-infarct origin (MID). This suppression is completely lacking when employed at low...
T1DM patients have a higher prevalence of eating disorders than the general population, and up to 30-40% young suffer from an disorder, including diabulimia. Eating worsen glycemic control make insulin therapy management more difficult. Closed loop systems (HCLS) allow major therapeutic flexibility; however, proper carbohydrate (CHO) counting remains fundamental feature for dose adjustments.
Introduction: The term empty sella refers to a shrunken or displaced (by subarachnoid diverticulum) pituitary gland. It can be primary (genetically determined) secondary (due trauma/surgery/radiation). has been reported that 50% of patients are asymptomatic, and others experience symptoms, such as headache, hypertension, visual field defects. Few cases have an syndrome, i.e., lacking functional hormones. Diagnosis is made through NMR CT. If this condition requires no treatment; otherwise,...
Due to the COVID-19 pandemic, current epidemiological conditions may exacerbate risk of new-onset, recurrence and relapse eating disorders. This perspective aims better analyse phenomenon.Some data suggest that new-onset recurrence/relapse disorders are increasing due pandemic. Government restrictions, self-confinement, social isolation, restriction healthcare facilities access, delayed access diagnosis cure, fear contagion, distress difficulties related telemedicine approach contribute this...