A5103014745- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
- Calcium signaling and nucleotide metabolism
- Immune Cell Function and Interaction
- RNA regulation and disease
- PI3K/AKT/mTOR signaling in cancer
- T-cell and B-cell Immunology
- Complement system in diseases
Centre for Inflammation Research
2018
Medizinische Hochschule Hannover
2015-2016
Subcellular compartmentalization of receptor signaling is an emerging principle in innate immunity. However, the functional integration pathways into membrane trafficking routes and its physiological relevance for immune responses still largely unclear. In this study, using Lyst-mutant beige mice, we show that lysosomal regulator Lyst links endolysosomal organization to selective control toll-like 3 (TLR3)- TLR4-mediated proinflammatory responses. Consequently, mice showed increased...
The immune system is tightly controlled by regulatory processes that allow for the elimination of invading pathogens, while limiting immunopathological damage to host. In present study, we found conditional deletion cell surface receptor Toso on B cells unexpectedly resulted in impaired proinflammatory T responses, which led protection an acute viral infection model and was associated with reduced tissue a chronic inflammatory context. exhibited its cell–inherent immunoregulatory function...
The transcription factor C/EBPβ plays a key role in monocytic differentiation and inflammation. Its small isoform LIP is associated with proliferation at early premonocytic developmental stages regulated via mTOR-dependent signalling. During later of (pre)monocytic there considerable increase the large isoforms LAP*/LAP which inhibit thus supporting terminal differentiation. Here, we showed different models that this dramatic protein LAP/LIP ratio was accompanied by an only modest/retarded...