A5014003966- Malaria Research and Control
- Veterinary Medicine and Surgery
- Mosquito-borne diseases and control
- Neonatal Health and Biochemistry
- Kidney Stones and Urolithiasis Treatments
- Metabolism and Genetic Disorders
- vaccines and immunoinformatics approaches
- Parasites and Host Interactions
- Trace Elements in Health
- Pediatric Urology and Nephrology Studies
- Hemoglobinopathies and Related Disorders
- Environmental DNA in Biodiversity Studies
- Trypanosoma species research and implications
- Evolution and Genetic Dynamics
- Renal function and acid-base balance
- Erythrocyte Function and Pathophysiology
- Abdominal Surgery and Complications
- Research on Leishmaniasis Studies
- Forensic and Genetic Research
- Renal and Vascular Pathologies
- Veterinary Oncology Research
- Xenotransplantation and immune response
- Computational Drug Discovery Methods
- Molecular Biology Techniques and Applications
- Livestock and Poultry Management
University of Technology Sydney
2018-2021
Westmead Hospital
2018-2021
The University of Sydney
2018-2021
International Council on Mining and Metals
2021
Westmead Institute for Medical Research
2018-2021
QIMR Berghofer Medical Research Institute
2021
Universidade Brasil
2010
Universidade de São Paulo
2010
Abstract Deletion of histidine-rich protein genes pfhrp2/3 in Plasmodium falciparum causes infections to go undetected by HRP2-based malaria rapid diagnostic tests. We analyzed P. cases imported Australia (n = 210, collected 2010–2018) for their status. detected gene deletions patients from 12 25 countries. found >10% pfhrp2-deletion levels those Nigeria (13.3%, n 30), Sudan (11.2%, 39), and South (17.7%, 17) low pfhrp3 deletion (3.6%) (5.9%). No parasites with double were detected....
Drug resistance within the major malaria parasites Plasmodium vivax and falciparum threatens control elimination in Southeast Asia. first-line treatment drug is chloroquine together with primaquine, for P. artemisinin combination a partner drug. resistant to their respective therapies are now found The perimeters may include high transmission regions of Southern Thailand which underrepresented surveillance efforts.This study investigated blood samples from centres Thailand. Genetic loci...
Background Plasmodium falciparum histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs) are exclusively recommended for malaria diagnosis in Uganda; however, their functionality can be affected by parasite-related factors that have not been investigated field settings. Methods Using a cross-sectional design, we analysed 219 RDT-/microscopy+ and 140 RDT+/microscopy+ dried blood spots obtained from symptomatic children aged 2–10 years 48 districts Uganda between 2017 2019. We...
Histidine-rich protein-2 (HRP2)-based rapid diagnostic tests (RDTs) are the only RDTs recommended for malaria diagnosis in Uganda. However, emergence of Plasmodium falciparum histidine rich protein 2 and 3 (pfhrp2 pfhrp3) gene deletions threatens their usefulness as surveillance tools. The pfhrp2 pfhrp3 was conducted P. parasite populations Uganda.Three-hundred (n = 300) isolates collected from cross-sectional surveys symptomatic individuals 48 districts eastern western Uganda were analysed...
Background The World Health Organization currently recommends artemisinin (along with a partner drug) as the global frontline treatment for Plasmodium falciparum malaria. Artemisinin resistant P. are now found throughout greater Mekong subregion of South East Asia. Several polymorphisms in parasite’s kelch gene have been demonstrated to confer resistance. While genotypes within thoroughly examined literature, populations several areas that do not (yet) endemic resistance underrepresented....
Abstract Background Genetic diversity and parasite relatedness are essential parameters for assessing impact of interventions understanding transmission dynamics malaria parasites, however data on its status in Plasmodium falciparum populations Uganda is limited. Microsatellite markers DNA sequencing were used to determine molecular characterization P. Uganda. Methods A total 147 genomic samples collected from cross-sectional surveys symptomatic individuals 2–10 years characterized by...
O estudo teve como objetivo avaliar os casos de urolitíase canina em que a composição mineral dos urólitos foi analisada quantitativamente. Foi avaliada quantitativamente 156 obtidos cães (nefrólitos, ureterólitos, urocistólitos e uretrólitos). Desse total, 79,5% (n=124) eram simples, 18% (n=28) compostos apenas 2,5% (n=4) mistos. A estruvita o tipo mais frequente nos simples (47,6%; n=59), todos mistos (100%; n=4) nas camadas núcleo pedra (32,1 75%, respectivamente). oxalato cálcio segundo...
High throughput sequencing of mtDNA and STRs enable forensic laboratories to have the benefits both analysis methods at same time. HTS chemistries are more cost effective than Sanger for mitochondrial genome produce data a greater depth coverage allowing detection low level heteroplasmy [[1]Holland M.M. Pack E.D. McElhoe J.A. Evaluation GeneMarker improved alignment MPS data, haplotype determination, assessment.Forensic Sci. Int. Genet. 2017; 28: 90-98Abstract Full Text PDF PubMed Scopus...
Purpose: Emerging drug resistance in Plasmodium falciparum imperils malaria control and elimination. Recently, to the frontline therapy artemisinin, combination partner drugs, is accelerating throughout South East Asia. Molecular surveillance of genetic markers a valuable tool inform policy forestall widespread resistance, however many regions are underrepresented molecular studies. This project aimed investigate imported cases from travellers, immigrants, refugees entering Australia report...
Abstract Background: Genetic diversity and parasite relatedness are essential parameters for assessing impact of interventions understanding transmission dynamics malaria parasites however data on its status in P. falciparum populations Uganda is limited. We used microsatellite markers DNA sequencing to determine molecular characterization Uganda. Methods : A total 147 genomic samples collected from cross-sectional surveys symptomatic individuals 2-10 years were characterized by genotyping...