A5027881414- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Phosphodiesterase function and regulation
- Head and Neck Cancer Studies
- Advances in Oncology and Radiotherapy
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Radiomics and Machine Learning in Medical Imaging
- Bacterial Genetics and Biotechnology
- Synthesis and Catalytic Reactions
- Neuroendocrine Tumor Research Advances
- Immunotherapy and Immune Responses
- Brain Metastases and Treatment
- Liver Disease and Transplantation
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Interpreting and Communication in Healthcare
- Cholinesterase and Neurodegenerative Diseases
- Ubiquitin and proteasome pathways
Tufts Medical Center
2021-2024
Brown University
2021-2023
Tufts University
2021-2023
LifeSpan Medical Institute
2023
Cancer Institute (WIA)
2023
Lifespan
2021-2023
Digital Health Cooperative Research Centre
2022
Rhode Island Hospital
2021-2022
University of Massachusetts Chan Medical School
2022
Digital China Health (China)
2022
Cytotoxic molecules can kill cancer cells by disrupting critical cellular processes or inducing novel activities. 6-(4-(Diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one (DNMDP) is a small molecule that kills generation of activity. DNMDP induces complex formation between phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12) specifically expressing elevated levels these two proteins. Here, we examined the characteristics covariates cell response to DNMDP. On...
In patients with locally advanced, unresectable non-small cell lung cancer (NSCLC), the standard of care is concurrent chemoradiation (CRT) followed by consolidative immunotherapy durvalumab. Pneumonitis a known adverse event both radiation therapy and immune checkpoint inhibitors such as We sought to characterize pneumonitis rates dosimetric predictors in real-world population NSCLC treated definitive CRT Patients from single institution who were durvalumab identified. Outcomes interest...
Summary The multidrug‐resistant, opportunistic pathogen, A cinetobacter baumannii , has spread swiftly through hospitals worldwide. Previously, we demonstrated that . regulates the expression of various genes in response to DNA damage. Some these regulated genes, especially those encoding multiple error‐prone polymerases, can be implicated induced mutagenesis, leading antibiotic resistance. Here, further explore damage‐inducible system at single cell level using chromosomal transcriptional...
Background: Accuracy of tumor bed (TB) delineation is essential for targeting boost doses or partial breast irradiation. Multiple studies have shown high interobserver variability with standardly used surgical clip markers (CMs). We hypothesize that a radiopaque filament marker (FM) woven along the TB will improve consistency. Methods: An FDA-approved FM was intraoperatively to outline patients undergoing lumpectomy. Between January 2020 and 2022, consecutive placed after either (1)...
The Escherichia coli protein DinB plays an important role in the SOS response to DNA damage. is a member of Y‐family polymerases which serve synthesize from damaged bulky template process known as translesion synthesis (TLS). particular only polymerase that conserved throughout all domains life. In addition synthesizing across lesions, associated with ‐1 frameshift mutations are particularly lethal. RecA and UmuD have already been shown modulate activity preventing mutation during TLS vitro,...
Abstract In a differential cytotoxicity screen, we identified novel small molecule modulator of phosphodiesterase 3A (PDE3A) that kills cancer cells expressing elevated levels PDE3A and SLFN12 (de Waal, Nat Chem Biol, 2016). Treatment with this cell-selective cytotoxic molecule, DNMDP, induces complex formation between SLFN12, resulting in apoptosis. Inhibition enzymatic activity is not sufficient for cell killing, expression both are required. Although the mechanism signaling to apoptosis...