A5035074969- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Meningioma and schwannoma management
- Lung Cancer Research Studies
- Management of metastatic bone disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Effects of Radiation Exposure
- Breast Cancer Treatment Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Multiple and Secondary Primary Cancers
- Radiopharmaceutical Chemistry and Applications
- Radiation Therapy and Dosimetry
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Prostate Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Lymphoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
UMass Memorial Medical Center
2014-2024
Memorial Medical Center
2015-2024
University of Massachusetts Chan Medical School
2015-2023
UMass Memorial Health Care
2014-2023
Rhode Island Hospital
2013-2016
Brown University
2013-2016
Penn State Milton S. Hershey Medical Center
2015
Massachusetts General Hospital
2015
University of Massachusetts Amherst
2014
Tufts Medical Center
2011-2013
Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular capable of transferring neutral lipids between membrane vesicles. Its role an essential chaperone for the biosynthesis apolipoprotein B (apoB)-containing triglyceride-rich lipoproteins established after realization that abetalipoproteinemia patients carry mutations in MTTP gene resulting loss its lipid activity. Now it is known also plays CD1, glycolipid presenting molecules, well regulation cholesterol...
Microsomal triglyceride transfer protein (MTP), an endoplasmic reticulum (ER) chaperone that loads lipids onto apolipoprotein B, also regulates CD1d presentation of glycolipid antigens in the liver and intestine. We show MTP RNA antigen-presenting cells (APCs) by reverse transcription–polymerase chain reaction immunoblotting mouse mononuclear human B cell lines. Functional MTP, demonstrated specific activity, is present both splenocytes a CD1d-positive NKT hybridoma. In novel vitro assay,...
The goal of this study was to evaluate outcomes in patients with ≥ 10 CNS metastases treated Gamma Knife stereotactic radiosurgery (GK-SRS).Patients brain using GK-SRS during the period between 2004 and 2010 were identified. Overall survival local regional control as well necrosis rates determined. influence age, sex, histological type, extracranial metastases, whole-brain radiation therapy, number analyzed Kaplan-Meier method. Univariate (log-rank) analyses performed, a p value < 0.05...
Microsomal triglyceride transfer protein (MTP), an endoplasmic reticulum lipid critical for apolipoprotein B (apoB) secretion, regulates CD1d antigen presentation. We identified MTP variant 1 (MTPv1), a novel splice of mouse MTP, by polymerase chain reaction and Northern analysis in non–apoB-secreting tissues, including thymocytes antigen-presenting cells (APCs). Edman degradation MTPv1 isolated from transfected revealed three unique residues; however, recombinant had equivalent disulfide...
Microsomal triglyceride transfer protein (MTP) activity is classically measured using radioactive lipids. We described a simple fluorescence assay to measure its triacylglycerol (TAG) activity. Here, we describe fluorescence-based methods the of phospholipids (PLs) and cholesteryl esters (CEs) by MTP. Both activities increased with time MTP amounts were inhibited different extents an antagonist, BMS197636. also method net deposition fluorescent lipids in acceptor vesicles. In this procedure,...
Microsomal triglyceride transfer protein (MTP) is essential for the assembly of neutral-lipid-rich apolipoprotein B (apoB) lipoproteins. Previously we reported that Drosophila MTP transfers phospholipids but does not triglycerides. In contrast, human both lipids. To explore acquisition activity by MTP, evaluated amino acid sequences, structures, and biochemical cellular properties various orthologues obtained from species diverged during evolution. All shared similar secondary tertiary...
// John Varlotto 1 , Flickinger 2 Martin T. Pavelic 3 Charles S. Specht 4 Jonas M. Sheehan 5, 6 Dana Timek Michael J. Glantz Steven Sogge 7 Christopher Dimaio 8 Richard Moser 9 Shakeeb Yunus 10 Thomas Fitzgerald Urvashi Upadhyay Paul Rava Matthew Tangel 11 Aaron Yao 12 Sangam Kanekar University of Massachusetts Medical Center, Department Radiation Oncology, Worcester, MA, USA Pittsburgh Pittsburgh, PA, Columbia Anesthesia, New York, NY, Penn State Hershey Pathology, Hershey, 5 Neurosurgery,...
Abstract To investigate the interrelation between economic, marital, and known histopathologic/therapeutic prognostic factors in presentation survival of patients with lung cancer nine different ethnic groups. A retrospective review SEER database was conducted through years 2007–2012. Population differences were assessed via chi‐square testing. Multivariable analyses ( MVA ) used to detect overall OS total population TP , N = 153,027) for those presenting Stage IV 70,968). Compared Whites,...
To identify predictors for prolonged survival free from salvage whole brain radiation therapy (WBRT) in patients with metastases treated stereotactic radiosurgery (SRS) as their initial radiotherapy approach.Patients SRS 2001 to 2013 at our institution were identified. without WBRT was typically offered 1-4 metastases, Karnofsky performance status ≥70, and life expectancy ≥3 months. Three hundred eight met inclusion criteria analysis. Medical records reviewed patient, disease, treatment...
Our purpose was to report outcomes in patients with Child-Pugh B or C (CP B/C) hepatocellular carcinoma (HCC) treated stereotactic body radiation therapy (SBRT).Patients HCC suitable for SBRT were prospectively enrolled the study from 2012 2018. Outcomes CP B/C analyzed. Cox proportional hazard models used compare survival between baseline score and post-SBRT score.Twenty-three a total of 29 tumors SBRT. Eighty-seven percent B8-C10. Median tumor size 3.1 cm (range, 1-10 cm). dose delivered...
Many patients treated with stereotactic radiosurgery (SRS) alone as initial treatment require 1 or more subsequent salvage therapies. This study aimed to determine if commonly used strategies are associated differing risks of radiation necrosis (RN). All upfront SRS for brain metastases at our institution were retrospectively analyzed. Salvage details obtained failures. Patients who underwent repeat the same lesion excluded. RN was determined based on pathological confirmation advanced...
Background: Little is understood regarding the inter-relation between economic, marital, and racial/ethnic differences in presentation survival of surgically-resected lung cancer patients. Our investigation will assess these addition to known therapeutic, patient, histopathologic factors. Methods: A retrospective review SEER database was conducted through years 2007-2012.The population split into 9 different ethnic groups. Population were assessed via chi-square testing. Multivariable...
Our objective was to report safety and efficacy of stereotactic radiosurgery (SRS) the surgical bed following resection brain metastases.Eighty-seven consecutive patients who underwent cavity-directed SRS operative for treatment metastases between 2002 2010 were evaluated. required a gadolinium-enhanced, high-resolution, T1-weighted magnetic resonance imaging tumor targeting delivered median dose 18 Gy (14-22 Gy) prescribed encompass entire cavity. Whole irradiation reserved salvage....
For patients with hepatocellular carcinoma awaiting liver transplantation (LT), stereotactic body radiation therapy (SBRT) has emerged as a bridging treatment to ensure maintain priority status and eligibility per Milan criteria. In this study, we aimed determine the efficacy safety of SBRT in such situations.A retrospective analysis was conducted outcomes 27 treated who were listed for LT at 1 institution. Among these, 20 26 tumors went on focus study. Operative reports postoperative charts...