Abstract Aliphatic amine, especially tertiary aliphatic is one of the most popular functionalities found in pharmaceutical agents. The Mannich reaction a classical and widely used transformation for synthesis β-amino-carbonyl products. Due to an ionic nature mechanism, can only use non-enolizable aldehydes as substrates, which significantly limits further applications this powerful approach. Here we show, by employing radical process, are able utilize enolizable substrates develop...

The synthesis of C1-ketonyl glycosyl compounds featuring α-selectivity has seldom been reported. We herein devise a radical-based approach to facilely access stereoenriched ketonyl via an Ir photoredox-catalyzed desulfurative addition silyl enol ethers, using in situ-generated tetrafluoropyridinyl thioglycosides from 1-thiols as radical precursors. This protocol features readily prepared starting materials, mild conditions, excellent functional group tolerance, satisfactory scale-up, and...

The nitrogen‐rich compound guanidine is widely distributed in nature, but its utilization hindered by strong resonance stabilization. GdmH, a binuclear nickel enzyme from Synechocystis sp. PCC 6803, capable of directly converting guanidinium cation into urea and ammonium. In this study, we employed density functional calculations to investigate the reaction mechanism GdmH using chemical model derived enzyme's X‐ray crystal structure. revealed that GdmH‐catalyzed hydrolysis proceeds through...

Introduction Obesity is a complex metabolic disease, which often accompanied with impaired glucose and lipid metabolism chronic inflammation. Probiotics have been considered as strategy for treating obesity, while the genus of Lactobacillus most commonly tested approved probiotics. Some multi-strain probiotics were proven to produce synergistic effects on obesity compared mono-strain ones. Methods The purpose this study was investigate anti-obesity effect new probiotic formation contained...

Visible light induced desulfurization–deuteration method was developed using D₂O as the source of deuterium atoms. This radical approach features mild conditions, broad substrate scope, highly efficient D-incorporation and excellent functional group compatibility.

Herein we report a photocatalytic oxidative radical addition reaction for the synthesis of unsymmetrical 1,4-dicarbonyl compounds. This utilizes desulfurization process to generate electrophilic radicals, which add α-halogenated alkenes and undergo further oxidation deliver mild highly efficient method provides valuable alternative known strategies.

Unsymmetrical 1,6-dicarbonyl compounds are useful building blocks in organic synthesis. However, the synthetic methods limited. Herein we report a three-component one-pot reaction for synthesis of unsymmetrical 1,6-diketones. This utilizes sulfides as radical precursors and enol ethers blocks. It takes advantage photocatalysis Lewis acid catalysis. Its utility was demonstrated modification biorelevant compounds.

Through a relay olefination and radical addition process, we developed cascade Wittig/hydroalkylation reactions induced by visible light. This metal-free approach features mild conditions, robustness, excellent functionality tolerance.

α-Keton sulfides are versatile building blocks in organic synthesis. From thioic acids and alkenes, we were able to develop the direct synthesis of α-keton thiol esters via photocatalytic oxidative radical additions. This reaction well matches idea green chemistry. It takes advantage thioxanthone as an inexpensive photocatalyst, O2 a oxidant, EtOAc solvent, visible light sustainable energy source, only byproduct is water.

SznF, a member of the emerging family heme-oxygenase-like (HO-like) di-iron oxidases and oxygenases, employs two distinct domains to catalyze conversion N

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition NaBH4 to in situ reduce unstable peroxyl radical intermediate much broadened substrate scope. Different sp3 carbon-bearing were successfully employed substrates, including phenylacetic acid-type well aliphatic acids. This transformation worked smoothly on primary, secondary, tertiary

Main observation and conclusion A visible‐light‐induced metal‐free desulfurization method for thiols disulfides has been explored. This radical features mild conditions, robustness, excellent functionality compatibility. It was successfully applied not only to the of small molecules, but also peptides.

Abstract Background Although the inherited risk factors associated with fatty liver disease are well understood, little is known about genetic background of metabolic dysfunction-associated steatotic (MASLD) and its related health impacts. Compared to non-alcoholic (NAFLD), MASLD presents significantly distinct diagnostic criteria, epidemiological clinical features, but variants yet be investigated. Therefore, we conducted this study assess interactions between MASLD-related...

Abstract Aminoglycoside antibiotics are widely used for many life‐threatening infections. The use of aminoglycosides is often comprised by their deleterious side effects to the kidney and inner ear. A novel semisynthetic antibiotic, etimicin, has good antimicrobial activity against both gram‐positive gram‐negative bacteria. But its toxicity profile analysis still lacking. In present study, we compared in vivo toxic three aminoglycosides, gentamicin, amikacin, zebrafish embryos. We examined...

Abstract The selective cleavage of C-C bonds is fundamental interest because it provides an alternative approach to traditional chemical synthesis, which focused primarily on building up molecular complexity. However, current methods provide only limited opportunities. For example, C(sp 3 )-C(sp ) bond generally relies the use transition-metal open strained ring systems or iminyl and alkoxy radicals induce β-fragmentation. Here we show that by merging photoredox catalysis with copper...

Selective halogenation is important in synthetic chemistry. BesD, a new member of the non-heme Fe(II)/α-ketoglutarate (αKG)-dependent halogenase family, can activate sp3 C-H bond and halogenate lysine, particular without carrier protein. Using density functional calculations, chlorination mechanism BesD has been proposed, mainly including formation Cl-Fe(IV)=O through αKG decarboxylation, isomerization Cl-Fe(IV)=O, substrate hydrogen abstraction by Fe(IV)=O, rebound chloro to carbon radical....

With the informationization of higher education, colleges and universities can fully apply online teaching mode to education teaching. Therefore, analysis factors affecting quality college teachers in effectively make evaluation object (teachers) have a sense achievement pride, so as mobilize enthusiasm stimulate consciousness honor shame competition. This study adopts application DEMATEL Cluster technology, conducts questionnaire survey on 5 Henan Province, analyzes identifies teachers’...

Cytochrome P450 1B1 (CYP1B1) is induced during the early stage of cancer and universally overexpressed in tumors. Thus, it was considered as a potential biomarker for monitoring cancer. In this study, we designed synthesized CYP1B1-targeted near-infrared (NIR) fluorescence molecular probes based on latest reported open conformation CYP1B1-α-naphthoflavone (ANF) complex. According to architecture channel, introduced linkers Cy5.5 fragment at 5′ position ANF derivatives with strong CYP1B1...

Metabolic dysfunction-associated steatotic liver disease (MASLD) poses a considerable health risk. Nevertheless, its risk factors are not thoroughly comprehended, and the association between reticulocyte count MASLD remains uncertain. This study aimed to explore relationship MASLD.

β,γ-Unsaturated carbonyl compounds serve as versatile building blocks in organic synthesis and medicinal chemistry. Herein we reported the of β,γ-unsaturated from tetrafluoropyridine sulfides with vinyl halides. This cross-coupling reaction takes advantage photocatalysis, well zinc catalysis, which is preferred due to its less-toxic, earth abundant, cost-effective nature.

The

Abstract Background Studies have reported that 5hmC features in cell-free DNA (cfDNA) could serve as early warning biomarkers for the occurrence and progression of COVID-19, well myocardial injury. However, its roles acute coronary syndrome (ACS) following COVID-19 infection not been fully studied. Methods Firstly, we used 5hmC-Seal technique to obtain genome-wide profiles from plasma cfDNA 24 ACS2N patients (individuals experiencing ACS onset within 2 months after infection), 28 ACS2W...

Unnatural amino acids (UAAs) are highly valuable building blocks in organic synthesis, pharmaceuticals, and material sciences. Previously, we developed the LADA strategy for synthesis of UAAs. Herein, further expanded scope this to alkenylboronic acids. Interestingly, both photoinduced single-electron transfer (SET) energy (EnT) processes were involved reaction,

In this work, a series of Ce3+ ions activated K2CaP2O7 phosphors were prepared through solid-state reaction method. The luminescence spectra in the ultraviolet-visible range as well decay curves studied. enter one Ca2+ site host, two emission bands are at 347 nm and 369 nm. five 4f–5d excitation centroid shift determined low temperature. critical energy transfer distance thermal quenching properties also discussed.