A5017005728- Cellular Mechanics and Interactions
- Mathematical Biology Tumor Growth
- Pancreatic function and diabetes
- Microtubule and mitosis dynamics
- Natural Products and Biological Research
- 3D Printing in Biomedical Research
- Liver physiology and pathology
- Spectroscopy and Chemometric Analyses
- Organ Transplantation Techniques and Outcomes
- Hibiscus Plant Research Studies
Miami University
2017-2021
Abstract Colorectal cancer and other cancers often metastasize to the liver in later stages of disease, contributing significantly patient death. While biomechanical properties parenchyma (normal tissue) are known affect tumor cell behavior primary metastatic tumors, role these driving or inhibiting inception remains poorly understood, as longer-term multicellular dynamics. This study adopts a multi-model approach dynamics tumor-parenchyma interactions during seeding growth. We employ...
The role of fluid stresses in activating the hepatic stem/progenitor cell regenerative response is not well understood. This study hypothesized that immediate early genes (IEGs) with known links to liver regeneration will be upregulated progenitor cells (LPCs) exposed vitro shear on order those produced from elevated interstitial flow after partial hepatectomy. objectives were: (1) develop a chamber for application stress LPCs 3D culture; and (2) determine effects IEG expression LPCs. Two...
ABSTRACT Colorectal cancer (CRC) and other cancers often metastasize to the liver in later stages of disease, contributing significantly patient death. While biomechanical properties parenchyma (normal tissue) are known affect tumor cell behavior primary metastatic tumors, role these driving or inhibiting inception remains poorly understood, as longer-term multicellular dynamics. This study adopts a multi-model approach dynamics tumor-parenchyma interactions during seeding growth. We employ...