A5090879419- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Disease and Adiposity
- Heparin-Induced Thrombocytopenia and Thrombosis
- Complement system in diseases
- Cell Adhesion Molecules Research
- Pharmacological Effects and Toxicity Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cholesterol and Lipid Metabolism
- Effects of Radiation Exposure
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Atherosclerosis and Cardiovascular Diseases
- Blood disorders and treatments
- Lipoproteins and Cardiovascular Health
- Dietary Effects on Health
- Multiple Myeloma Research and Treatments
- Dialysis and Renal Disease Management
- Cancer, Lipids, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Blood groups and transfusion
University of Arkansas for Medical Sciences
2014-2025
Arkansas Children's Hospital
2025
Arkansas Children's Nutrition Center
2022-2024
University of Illinois Chicago
2013
Significance The human circulatory system includes the heart, arteries, veins, and capillaries, all of which are lined by endothelial cells to prevent escape vascular contents into surrounding tissues. Platelets blood that best known for their essential role in preventing loss after injury. Here, we employed sensitive methods measure changes barrier function vivo used them identify a platelets maintaining homeostasis. results highlight platelet collagen receptors dense granules, show vessels...
The platelet glycoprotein Ib-IX (GP Ib-IX) receptor is a well-characterized adhesion supporting hemostasis and thrombosis via interactions with von Willebrand factor. We examine the GP Ib-IX/von factor axis in murine polymicrobial sepsis, as modeled by cecal ligation puncture (CLP).Genetic absence of ligand, factor, prolongs survival after CLP, but receptor, Ib-IX, does not. Because either or significantly impairs thrombosis, we sought to define additional Ib-IX-dependent pathways impacting...
Perivascular adipose tissue (PVAT) regulates vascular tone and is composed of adipocytes several leukocyte subpopulations. Diet can modify PVAT function, as obesogenic diets cause morphological changes to skew the phenotype, leading dysregulation impaired vasoregulation. Of note, platelets, clot-forming cells, also modulate many facets activity, such infiltration polarity. We aimed determine whether platelets regulate populations residing within PVAT. Male C57Bl/6J mice were fed a Western...
Objective— Poor prognosis of sepsis is associated with bacterial lipopolysaccharide (LPS)-induced intravascular inflammation, microvascular thrombosis, thrombocytopenia, and disseminated coagulation. Platelets are critical for there has been increasing evidence the importance platelets in endotoxemia. The platelet adhesion receptor, glycoprotein Ib-IX complex (GPIb-IX), mediates to inflammatory vascular endothelium exposed subendothelium. Thus, we have investigated role GPIb-IX LPS-induced...
No study has compared pharmacologic properties of ticagrelor and clopidogrel in non-dialysis patients with stage 4–5 chronic kidney disease (CKD). We conducted a double-blind RCT to compare effects 48 CKD, the primary outcome ADP-induced platelet aggregation (WBPA) after 2 weeks DAPT. In parallel arm, we plus aspirin on mean changes WBPA markers thromboinflammation among non-CKD controls (n = 26) that CKD ticagrelor-arm. Average age was 53.7 years, 62% women, 54% African American, 42% 5 CKD....
We examined a set of 805 cases that underwent DNA sequencing using the FoundationOne Heme (F1H) targeted panel and gene expression profiling. Known likely variant calls from mutational data were analyzed for significant associations with defined translocation cyclin D (TC) molecular subgroups. The spectrum KRAS, NRAS, BRAF codon mutations varied across subgroups NRAS at Q61 being common in hyperdiploid (HRD) t(11;14) myeloma while rare MMSET MAF. In addition, presence RAS-RAF was inversely...
Key Points Patients with CKD have a reduced platelet count, higher volume, platelet-leukocyte interactions, and nonclassic monocytes. Platelet-derived cytokines are one of the central in correlation analysis 45-cytokine panel patients stages 4 or 5 CKD. Antiplatelet drugs had multifaceted effects on thromboinflammation, suggesting platelet-dependent -independent inflammation Background Chronic kidney disease (CKD) is characterized by dysregulated that worsens severity. The role platelets...
Abstract Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation being recognized. Here, we focus the platelet membrane receptor, glycoprotein VI (GPVI), its role in microparticle (pMP) release. The GPVI receptor is platelet-specific collagen that, upon ligand binding,...
At present, the worldwide prevalence of obesity has become alarmingly high with estimates foreshadowing a continued escalation in future. Furthermore, there is growing evidence attributing an individual’s predisposition for developing to maternal health during gestation. Currently, 60% pregnancies US are either overweight or obese mothers which turn contributes persistent rise rates. While itself problematic, it conveys increased risk several diseases such as diabetes, inflammatory...
The correlation between obesity and cardiovascular disease has long been understood, yet scant investigations endeavored to determine the impact of an obesogenic diet on platelet activation or function. As platelets drive clot formation, terminus events, we aimed elucidate longitudinal effect phenotype by assessing markers using flow cytometry. Male, weanling mice were fed either a Western (30% kcal sucrose, 40% fat, 8.0% sodium) Control (7% 10% 0.24% sodium). At 12, 16 20 weeks diets,...
Background: Perivascular adipose tissue (PVAT) is an adipocyte and leukocyte depot that encircles most peripheral arteries aids in the regulation of vascular tone. Under normal physiological conditions PVAT mediates relaxation, but under obesogenic conditions, such as those caused by poor nutrition, loses its anti-contractile properties, thus contributing to increased This change phenotype marked replacement native anti-inflammatory leukocytes with pro-inflammatory counterparts which...
Background: While it is known that obesity increases the risk for cardiovascular disease (CVD), there has been no clear investigation into effect an obesogenic diet exerts onto circulating platelets. As platelets are critical actors in formation of occlusive clots manifest as a myocardial infarction or stroke, pertinent to establish any potential link between and platelet activity. Methods: To examine Western on baseline activity, male C57BL6/J mice were fed either control (10% fat, 7%...
A dynamic reciprocating crosstalk between cancer cells and platelets presents both opportunities challenges for an increased understanding of tumorigenesis improved patient therapies (1). The importance this relationship finds merit in the widespread use cardiovascular that target normal platelet function but impact diseases seemingly unrelated to hemostasis or thrombosis (2). In case cancer, there exists expanding databases support anti-cancer effects common medications, such as aspirin...
Perivascular adipose tissue (PVAT) is an depot surrounding blood vessels and a paracrine regulator of vascular tone. Obesity associated with the loss PVAT-mediated anti-contractile properties, thus contributing to obesity-associated hypertension. Hydrogen sulfide (H2 S) gaseous signaling molecule that produced in vasculature important for regulating In PVAT, cystathionine gamma lyase (Cse) primary source H2 S which acts as adipose-derived relaxing factor. Dietary methionine restriction...