Abstract Background Tumor-associated macrophages (TAMs) play an important role in growth, progression and metastasis of tumors. In non-small cell lung cancer (NSCLC), TAMs' anti-tumor or pro-tumor is not determined. Macrophages are polarized into M1 (with function) M2 forms. This study was conducted to determine whether the macrophage densities NSCLC associated with patient's survival time. Methods Fifty patients average 1-year (short group) 50 5-year (long were included this retrospective...

Abstract Background Tumor microenvironment is composed of tumor cells, fibroblasts, endothelial and infiltrating immune cells. Tumor-associated cells may inhibit or promote growth progression. This study was conducted to determine whether the number microlocalization macrophages, mature dendritic cytotoxic T in non-small cell lung cancer are associated with patient's survival time. Methods Ninety-nine patients (NSCLC) were included this retrospective study. Paraffin-embedded NSCLC specimens...

Dysregulated microRNAs (miRNAs) play crucial roles in the regulation of cancer stem cells (CSCs), and CSCs are closely associated with tumor initiation, metastasis, recurrence. Here we found that miR-150-5p was significantly downregulated non-small-cell lung (NSCLC) its expression level negatively correlated disease progression poor survival patients NSCLC. Inhibition increased CSC population sphere formation NSCLC vitro stimulated cell tumorigenicity metastatic colonization vivo. In...

Recurrence is a challenge to survival after the initial treatment of esophageal squamous cell carcinoma (ESCC). But, its mechanism remains elusive and there are currently no biomarkers predict postoperative recurrence. Here, possibility sterile alpha motif domain-containing protein 9 (SAMD9) as predictor recurrence ESCC evaluated molecular mechanisms by which SAMD9 promotes elucidated. The authors found that high level correlated with poor prognosis ESCC. Overexpression tumor stemness,...

Background: Video-assisted thoracic surgery (VATS)-assisted lobectomy is widely used to treat non-small cell lung carcinoma (NSCLC). There are no reports concerning the comparison between single-port VATS and two-port in treating NSCLC. This study aimed compare perioperative short-term follow-up results these two methods for

Sarcoidosis, a multisystemic immune disease, significantly impacts patients' quality of life. The complexity and diversity its pathogenesis, coupled with limited comprehensive research, had hampered both diagnosis treatment, resulting in an unsatisfactory prognosis for many patients. In recent years, the research made surprising progress triggers sarcoidosis (genetic inheritance, infection environmental factors) abnormal regulations on immunity during formation granuloma. This review...

Breast cancer is the most prevalent malignant disease among women and affects of reproductive age (15-49 years) across globe. This study examines patterns trends in epidemiology breast using global burden data (1990-2021), with objective informing targeted public health strategies. Using from Global Burden Disease Study (GBD 2021), this analyzed temporal trends, regional disparities, inequalities 204 countries territories 1990 to 2021. The analysis employed methodologies including...

Depressive disorders significantly impact women of reproductive age (15–49 years), who face unique biological and social pressures—such as hormonal changes caregiving responsibilities—that elevate their mental health risks. Despite rising prevalence, regional disparities in burden remain poorly understood. Moreover, no studies to date have examined the relationship between depressive different categories workforce. This study examines global, regional, national trends from 1990 2021,...

Background Postoperative circulation tumor DNA (ctDNA) is a promising method to predict the risk of recurrence. However, amount ctDNA in patients with early NSCLC too small. Cell damages caused during intraoperative period leads significant increase cell free (cfDNA). Whether cfDNA content restored preoperative level within short time after surgery may indicate degree surgical trauma. In this study, dynamic changes combined perioperative were used explore possibility them as biomarker...

Background Programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors displayed considerable advantages in neoadjuvant therapy of non-small cell lung cancer (NSCLC), but the specific application immunotherapy has not been well determined, and long-term prognostic data immunochemotherapy combined with surgical resection NSCLC remains limited. In this study, we intended to assess efficacy PD-1 inhibitor prognosis patients resectable NSCLC. Methods We retrospectively analyzed...

Current treatment strategies for advanced non-small cell lung cancer (NSCLC) are highly individualized and subject to ongoing debates. In the era of immunotherapy, surgery assumes a critical role. The aim this study was investigate if subsequent surgical intervention, following favorable response immunotherapy chemotherapy, could yield more prognosis patients with stage III NSCLC compared continuation chemotherapy.

Cough is a common complication after pulmonary resection. However, the factors associated with cough that develop resection are still controversial. In this study, we used Simplified Score (SCS) and Leicester Questionnaire (LCQ) score to investigate potential risk for postoperative cough. Between January 2017 June 2021, collected clinical data of 517 patients, SCS at three days surgery LCQ two weeks six surgery. Then, univariate multivariate analyses were identify independent The baseline...

Cough is a major complication after lung cancer surgery, potentially impacting function and quality of life. However, effective treatments for managing long-term persistent postoperative cough remain elusive. In this study, we investigated the potential pulmonary rehabilitation training program to effectively address issue.

To present clinical experiences regarding surgical treatment of patients with severe cicatricial tracheal stenosis.From January 2008 to March 2020, 14 underwent resection and reconstruction under general anesthesia. Nine cases had cervical stenosis five thoracic stenosis. The mean diameter length strictured trachea was 0 - 8 mm a 4.5 ± 2.4 1 3 cm 1.67 0.63 cm, respectively. General anesthesia mechanical ventilation were performed in ten four femoral arteriovenous bypass surgery due...

Chronic obstructive pulmonary disease (COPD) will reduce the cardiopulmonary function and increase perioperative risk. The aim of this study is to investigate effect preoperative short-term high intensity lung rehabilitation training on postoperative complications in patients with COPD who are eligible for cancer surgery.We analysis 101 a diagnosis cancer, 43 group 58 conventional group. function, (PPCs) length stay (LOS) be compared between two groups, before after at same time.There were...

In this study, we aimed to summarize the extremely important lesson and experience in whole process of surgical treatments lung tumors for benefit steps taken prevent against unplanned reoperation.Demographical clinical information 7732 patients were retrospectively retrieved reviewed, who diagnosed with pulmonary tumor underwent from January 2016 March 2021. Those reoperation treatment severe complications focused carefully analyzed meticulously.A total forty-one (41/7732) received 44...

The optimal surgical approach for elderly patients with early-stage non-small cell lung cancer (NSCLC) remains a topic of debate. A retrospective analysis was conducted on who underwent pulmonary resection NSCLC at our single institution between January 2018 and December 2022. Propensity score matching used to balance baseline characteristics the sublobar lobectomy groups. Perioperative outcomes, function recovery, postoperative quality life, survival were compared two total 151 included, 42...

In this paper, the mechanism of destroying human alveolar epithelial cells and pulmonary tissue by 2019 novel coronavirus (2019-nCoV) was discussed firstly. There may be multiple mechanisms including killing directly target hyperinflammatory responses. Secondly, clinical features, CT imaging, short-term long-term function damage disease (COVID-19) analyzed. Finally, some suggestions for thoracic surgery practice in non-epidemic area during after epidemic COVID-19 were provided, to help all...

Background: Esophageal squamous cell carcinoma (ESCC) is a primary subtype of esophageal cancer (EC), with high morbidity and mortality. This study aimed to identify aberrant expression profiling non-coding RNAs in ESCC metastasis. Methods: The lncRNA/miRNA/mRNA was measured by RNA-sequencing tumor loci patients metastasis (metastasis group) without (primary group). Differentially expressed (DELs/DEMIs/DEMs) were identified group. DEMIs-DEMs interaction network, Kyoto Encyclopedia Genes...