A5051905577- Animal testing and alternatives
- Carcinogens and Genotoxicity Assessment
- Pesticide Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Agricultural safety and regulations
- Pesticide and Herbicide Environmental Studies
- Environmental Toxicology and Ecotoxicology
- Immunotoxicology and immune responses
- Insect Resistance and Genetics
- Pharmacogenetics and Drug Metabolism
- Methemoglobinemia and Tumor Lysis Syndrome
- Reproductive Biology and Fertility
- Pesticide Residue Analysis and Safety
- Algal biology and biofuel production
- Plant tissue culture and regeneration
- Toxic Organic Pollutants Impact
- Pharmaceutical studies and practices
- Sperm and Testicular Function
- Ovarian function and disorders
- Contact Dermatitis and Allergies
- Weed Control and Herbicide Applications
- Genetic Neurodegenerative Diseases
- Insect and Pesticide Research
- Chemical Safety and Risk Management
- Dye analysis and toxicity
Adama (Israel)
2019
Adama Science and Technology University
2019
The physiological factors which induce and maintain mammalian sperm maturation motility generally remain unclear, although several agents are known to be involved. We describe here the application of immunocytochemical immunoblotting methods identify angiotensin II type 1 (AT1) receptor in tails ejaculated rat human sperm. Motility data on stimulated unstimulated from volunteers patients attending fertility clinics showed that may increase both percentage motile their linear velocity, while...
The present agrochemical safety evaluation paradigm is long-standing and anchored in well-established testing procedures. However, it does not meet the present-day challenges of rapidly growing populations, food insecurity, pressures from climate change. To transform current framework apply modern strategies that better support sustainable agriculture, Health Environmental Sciences Institute (HESI) assembled a technical committee to reframe crop-protection products. composed international...
A comprehensive biometrical assessment was conducted to compare the performance of multiple test designs for acute dermal systemic toxicity support animal welfare update original OECD Test Guideline (TG) 402 toxicity. The evaluated included: (1) two, three, or five animals per dose group (2) evident lethality endpoints and (3) absence presence a one-animal sighting study. revision TG respected 3R principles (replace, reduce, refine) testing. results demonstrate that design can be optimised...
The metabolism and elimination of a xenobiotic has direct bearing on its potential to cause toxicity in an organism. confidence with which data from safety studies can be extrapolated humans depends, among other factors, upon knowing whether are systemically exposed the same chemical entities (i.e. parent compound metabolites) as laboratory animals used study toxicity. Ideally, understand metabolite terms safety, both structure systemic exposure would need determined. However, blood...
Understanding and estimating the exposure to a substance is one of fundamental requirements for safe manufacture use. Many approaches are taken determine substances, mainly driven by potential use regulatory need. There many opportunities improve optimise information chemical safety. The European Partnership Alternative Approaches Animal Testing (EPAA) therefore convened Partners' Forum (PF) explore considerations in human safety assessment industrial products agree key conclusions...
A global, harmonized evaluation system for crop protection chemicals based on exposure and risk will improve the ability to inform management decisions better support innovation. This would be achieved through assessment-based regulatory decision-making realized application of best available science, via integration new methods traditional data create tailored exposure-driven assessments. requirement achieve success is a structure that encourages direct communication between community...
The mouse local lymph node assay (LLNA) has become the preferred test for evaluating dermal sensitization potential of chemicals and requirements are now emerging its use in evaluation their formulated products, especially European Union. However, despite widespread extensive validation, this directly testing mixtures products been questioned, which could lead to repeat using multiple animal models. As pesticide formulations typically a specific complex blend as aqueous-based dilutions,...
Dermal absorption data are required on agrochemical formulations to conduct risk assessments for subpopulations who may be exposed dermally the formulation and/or its spray dilution, example, operators/sprayers, bystanders (incidental and residential), re-entry workers. In absence of formulation-specific data, European Food Safety Authority (EFSA) guidance proposes highly conservative default values very limited opportunities read-across existing data. this case study, from GLP OECD 428 test...