A5027578682- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Bone fractures and treatments
- Surgical Simulation and Training
- Cervical and Thoracic Myelopathy
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Anatomy and Medical Technology
- Mesenchymal stem cell research
- Medical Imaging and Analysis
- Sarcoma Diagnosis and Treatment
- Digital Imaging in Medicine
- Bone Tumor Diagnosis and Treatments
- Spinal Dysraphism and Malformations
- Meningioma and schwannoma management
- Management of metastatic bone disease
- Acute Ischemic Stroke Management
- Brain Metastases and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Cerebrovascular and Carotid Artery Diseases
- Tissue Engineering and Regenerative Medicine
University of Southern California
2019-2025
Keck Hospital of USC
2022-2024
Southwest Healthcare System
2023
Billings Clinic
2023
Mayo Clinic in Florida
2023
WinnMed
2023
Children's National
2023
Neurological Surgery
2023
<h3>Background</h3> As the elderly population grows, increasing prevalence of osteoporosis presents a unique challenge for surgeons. Decreased bone strength and quality are associated with hardware failure impaired healing, which may increase rate revision surgery development complications. The purpose this review is to determine impact on postoperative outcomes patients cervical degenerative disease or deformity. <h3>Methods</h3> A systematic using Preferred Reporting Items Systematic...
Ex vivo regional gene therapy is a promising tissue-engineering strategy for bone regeneration: osteogenic mesenchymal stem cells (MSCs) can be genetically modified to express an osteoinductive stimulus (e.g., morphogenetic protein-2), seeded onto osteoconductive scaffold, and then implanted into defect exert therapeutic effect. Compared recombinant human BMP-2 (rhBMP-2), which approved clinical use, may have unique benefits related the addition of MSCs sustained release BMP-2. However,...
Experts can assess surgeon skill using surgical video, but a limited number of expert surgeons are available. Automated performance metrics (APMs) promising alternative have not been created from operative videos in neurosurgery to date. The authors aimed evaluate whether video-based APMs predict task success and blood loss during endonasal endoscopic surgery validated cadaveric simulator vascular injury the internal carotid artery.
<h3>Importance</h3> Surgical data scientists lack video sets that depict adverse events, which may affect model generalizability and introduce bias. Hemorrhage be particularly challenging for computer vision–based models because blood obscures the scene. <h3>Objective</h3> To assess utility of Simulated Outcomes Following Carotid Artery Laceration (SOCAL)—a publicly available surgical set hemorrhage complication management with instrument annotations task outcomes—to provide benchmarks...
When delivering cells on a scaffold to treat bone defect, the cell seeding technique determines number and distribution of within scaffold, however optimal has not been established. This study investigated if human adipose-derived stem (ASCs) transduced with lentiviral vector overexpress morphogenetic protein 2 (BMP-2) loaded using dynamic orbital shaker could reduce total dose required heal critical sized defect when compared static seeding. Human ASCs were onto collagen/biphasic ceramic...
Background: There is considerable heterogeneity in findings and a lack of consensus regarding the interplay between osteoporosis outcomes patients with lumbar degenerative spine disease. Therefore, purpose this systematic review meta-analysis was to gather analyze existing data on effect radiographic, surgical, clinical following surgery for spinal disease.Methods: A performed determine incidence adverse after surgical intervention diseases. The approach focused radiographic outcomes,...
Study Design: Systematic review and meta-analysis. Objective: To compare radiographic outcomes across lumbar interbody fusion (LIF) techniques, assessing segmental global lordosis restoration. Summary of Background Data: LIF is a commonly utilized procedure to treat various spinal conditions, including degenerative pathology adult deformity. Common approaches include posterior (PLIF), transforaminal (TLIF), anterior (ALIF), oblique (OLIF), lateral (LLIF). Methods: A systematic meta-analysis...
Aneurysmal bone cysts are benign osseous lesions containing blood-filled cavities separated by walls of connective tissue. They can be difficult to identify clinically due similarities in presentation, imaging, and histology with other pathologies. Specifically, it is important distinguish these from malignant processes, as both surgical medical management differ. We present the case a 21-year-old patient who presented impaired motor sensory function his lower extremities. Radiologic...
Novel treatment strategies for segmental bone loss in orthopaedic surgery remain under investigation. Regional gene therapy that involves transduction of mesenchymal stem cells with a lentiviral vector expresses BMP-2 has gained particular interest as this strategy provides osteogenic and osteoinductive factors growth. In particular, transduced adipose-derived stems (ASCs) marrow-derived (BMSCs) have emerged the leading candidates defects preclinical models. The aim present study was to...