A5045904632- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Wnt/β-catenin signaling in development and cancer
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Hepatitis B Virus Studies
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Hepatitis C virus research
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Viral-associated cancers and disorders
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
Chinese General Hospital College of Nursing and Liberal Arts
2020-2024
Chinese People's Liberation Army
2020-2024
Chinese PLA General Hospital
2020-2022
People's Liberation Army No. 150 Hospital
2020
Background: Immune and stromal cells in the tumor microenvironment (TME) significantly contribute to prognosis of lung adenocarcinoma; however, TME-related immune prognostic signature is unknown. The aim this study was develop a novel model TME adenocarcinoma. Methods: First, scores among adenocarcinoma patients were determined using ESTIMATE algorithm accordance with Cancer Genome Atlas (TCGA) database. Differentially expressed immune-related genes (IRGs) between high low immune/stromal...
Abstract Background Clinical trials have shown that anti-PD1 therapy, either as a monotherapy or in combination, is effective and well-tolerated patients with recurrent unresectable hepatocellular carcinoma (HCC). In this study, we aimed to investigate the prognostic value of immune-nutritional biomarkers measuring effects therapy these patients. Methods We enrolled followed up 85 diagnosed advanced HCC who underwent at First Medical Centre Chinese People’s Liberation Army (PLA) General...
Liver hepatocellular carcinoma (LIHC) and cholangiocarcinoma (CHOL) are common primary liver cancers worldwide. stem cells have biopotential to differentiate into either hepatocytes cholangiocytes, the phenotypic overlap between LIHC CHOL has been acceptable as a continuous cancer spectrum. However, few studies directly investigated underlying molecular mechanisms CHOL.To identify candidate genes CHOL, three data series including GSE31370, GSE15765 GSE40367 were downloaded from Gene...
Objective Aberrant activation of Wnt/β-catenin signaling contributes to the maintenance cancer stem cells and chemoresistance in colorectal (CRC). Retinoic acid-induced 2 (RAI2) was proved be a tumor suppressor CRC our previous report. In this study, role RAI2 further investigated. Methods As transcriptional co-regulator, C-terminal Binding Protein (CtBP2) reported involved Wnt multiple complex ways. The correlation CtBP2 analyzed by TCGA dataset, interaction between explored...
China is a high endemic area for the hepatitis B virus (HBV). The studies established epidemiology between HBV and diffuse large B-cell lymphoma (DLBCL), but further research necessary to clarify potential link DLBCL.A total of 319 patients diagnosed with DLBCL were recruited as cases at First Medical Centre Chinese PLA General Hospital from September 2010 December 2018. During same time, two age- sex-matched controls selected each case, control groups comprised non-hematological malignancy...
4592 Background: Advanced HCC is a deadly disease with few systemic therapeutic options. VEGF blockade potentiates the effect of PD-1 inhibition by opposing immunosuppressive effects VEGF-A (increased DC maturation, enhanced T-cell infiltration, reduced MDSCs and Tregs in tumors). A sBLA has been submitted for an anti-PD-L1 + anti-VEGF combination as 1L treatment advanced HCC. Penpulimab novel humanized anti-PD-1 IgG1 antibody complete removal Fc receptor mediated effect, featuring slow...
The main aim of this study was to compare the efficacy and safety different biliary drainage strategies, including percutaneous transhepatic (PTBD) versus endoscopic stenting (EBS) unilateral bilateral stenting, in patients with unresectable malignant hilar strictures (MHBSs).This a retrospective review inoperable MHBSs who underwent by either EBS or PTBD. Efficacy were compared between two pathways group. survival duration analyzed K-M curves Log rank tests.From January 2015 December 2019,...
<title>Abstract</title> <bold>Background:</bold> The widespread application of computed tomography (CT) for pulmonary disease screening has led to an increased detection nodules. However, this also resulted in a high false-positive rate suspected malignancies that ultimately prove be benign. It is crucial explore the clinical and imaging characteristics these patients avoid unnecessary major resections. This study aims evaluate surgically resected benign nodules were initially presumed lung...
Increasing bodies of evidence reveal that targeting a programmed cell death protein 1 (PD-1) monoclonal antibody is promising immunotherapy for lung adenocarcinoma. Although PD receptor ligand (PDL1) expression widely recognized as the most powerful predictive biomarker anti-PD-1 therapy, its regulatory mechanisms in adenocarcinoma remain unclear. Therefore, we conducted this study to explore differentially expressed genes (DEGs) and elucidate mechanism PDL1 adenocarcinoma.The GSE99995 data...
Abstract Background: A hepatitis B virus (HBV) infection is one of the major risk factors hepatocellular carcinoma (HCC) in China. Altered expression miRNAs has been observed tumors. Our study aimed to identify potential microRNAs (miRNA)-messenger RNAs (mRNAs) regulatory pathways contributing pathogenesis HBV-related HCC. Methods: Microarray GSE67882 was downloaded from Gene Expression Omnibus (GEO) database. GEO2R used conduct differential analysis. Functional enrichment...
306 Background: Combined therapy of an immune checkpoint inhibitor with a targeted antiangiogenic agent had been proved to be effective for the treatment uHCC. Penpulimab was engineered eliminate FcγR binding and ADCC/ADCP completely, where effects could induce T-cell apoptosis clearance then compromise anti-tumor activity. demonstrated slower PD-1 antigen off-rate, which resulted in better cellular activity higher receptor occupancy. also showed numerous contacts N58 glycosylation on BC...