A5082101935- Genetics, Aging, and Longevity in Model Organisms
- Cardiac Arrest and Resuscitation
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Prenatal Screening and Diagnostics
- Respiratory Support and Mechanisms
- Fetal and Pediatric Neurological Disorders
- Single-cell and spatial transcriptomics
- Genetic Mapping and Diversity in Plants and Animals
- Gene expression and cancer classification
- Evolution and Genetic Dynamics
- Ethics in Clinical Research
- Birth, Development, and Health
- RNA modifications and cancer
- Airway Management and Intubation Techniques
- Genetics and Physical Performance
- Cytokine Signaling Pathways and Interactions
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Neonatal Respiratory Health Research
- Spaceflight effects on biology
- Organophosphorus compounds synthesis
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Balance, Gait, and Falls Prevention
- Synthesis and characterization of novel inorganic/organometallic compounds
University of Chicago
2019-2025
Duke University
2014-2019
University of Illinois Chicago
2019
Trinity College
2015
University of Toronto
2005
Noninvasive prenatal genetic testing is becoming available worldwide--particularly in low- and middle-income countries--but practical ethical challenges must be overcome.
daf-16/FoxO is required to survive starvation in Caenorhabditis elegans, but how daf-16IFoxO promotes resistance unclear. We show that restructures carbohydrate metabolism by driving carbon flux through the glyoxylate shunt and gluconeogenesis into synthesis of trehalose, a disaccharide glucose. Trehalose well-known stress protectant, capable preserving membrane organization protein structure during abiotic stress. Metabolomic, genetic, pharmacological analyses confirm increased trehalose...
Maternal effects of environmental conditions produce intergenerational phenotypic plasticity. Adaptive value these depends on appropriate anticipation in the next generation, and mismatch between may contribute to disease. However, regulation plasticity is poorly understood. Dietary restriction (DR) delays aging but maternal have not been investigated. We demonstrate DR roundworm C. elegans. Worms cultured fewer larger progeny. Nutrient availability assessed late larvae young adults, rather...
ABSTRACT Background Perioperative myocardial infarction (PMI) after noncardiac surgery results in significant morbidity and mortality. While comprehensive management, including imaging guideline‐directed medical therapy (GDMT), improves outcomes, utilization of these strategies the impact physician evaluation on their are unknown. This study evaluates frequency cardiology PMI its association with guideline‐recommended care. Methods Using IBM MarketScan (2016–2021), we analyzed claims for...
Parts-based representations, such as non-negative matrix factorization and topic modeling, have been used to identify structure from single-cell sequencing data sets, in particular that is not well captured by clustering or other dimensionality reduction methods. However, interpreting the individual parts remains a challenge. To address this challenge, we extend methods for differential expression analysis allowing cells partial membership multiple groups. We call grade of (GoM DE)....
To understand the genetic basis of complex traits, it is important to be able efficiently phenotype many genetically distinct individuals. In nematode Caenorhabditis elegans, individuals have been isolated from diverse populations around globe and whole-genome sequenced. As a result, hundreds wild strains with known genome sequences can used for genome-wide association studies (GWAS). However, phenotypic analysis these laborious, particularly quantitative traits requiring multiple...
Noninvasive prenatal testing (NIPT), a new technology that uses cell-free fetal DNA in maternal plasma to detect aneuploidies, is currently entering clinical practice. NIPT offers great benefits as it much more accurate than current screening, allows earlier testing, and eliminates the risk of miscarriage associated with amniocentesis chorionic villus sampling (CVS). In future, may become enough replace invasive testing. To date, no attention has been given literature role through might play...
Parts-based representations, such as non-negative matrix factorization and topic modeling, have been used to identify structure from single-cell sequencing data sets, in particular that is not well captured by clustering or other dimensionality reduction methods. However, interpreting the individual parts remains a challenge. To address this challenge, we extend methods for differential expression analysis allowing cells partial membership multiple groups. We call grade of (GoM DE)....
Functional capacity assessment is a core component of current perioperative cardiovascular evaluation and management guidelines for noncardiac surgery. The authors investigated the ability standardized physical function questions to predict whether participants engaged in moderate activity as measured by hip accelerometers.Participant responses functioning they were extracted from National Health Nutrition Examination Survey (2003 2004 2005 2006). Physical intensity was using accelerometers....
<ns4:p><ns4:bold>Background: </ns4:bold>Both genetic and environmental factors appear to contribute joint health disease. For example, pathological levels of biomechanical stress on joints play a notable role in initiation progression osteoarthritis (OA), common chronic degenerative disease affecting articular cartilage underlying bone. Population-level gene expression studies cells experiencing may uncover gene-by-environment interactions relevant human health.</ns4:p><ns4:p>...
Variable temperature n.m.r. spectra are consistent with hindered rotation about the P–N bond in bis-(1,2-dimethylhydroxylamino)halogenophosphines.
Abstract Osteoarthritis ( OA ) is a common chronic degenerative joint disease affecting articular cartilage and underlying bone. Both genetic environmental factors appear to contribute the development of this disease. Specifically, pathological levels biomechanical stress on joints play notable role in initiation progression. Population-level gene expression studies cells experiencing may uncover gene-by-environment interactions relevant human health. To build foundation for such studies, we...
<ns4:p><ns4:bold>Background: </ns4:bold>Both genetic and environmental factors appear to contribute joint health disease. For example, pathological levels of biomechanical stress on joints play a notable role in initiation progression osteoarthritis (OA), common chronic degenerative disease affecting articular cartilage underlying bone. Population-level gene expression studies cells experiencing may uncover gene-by-environment interactions relevant human health.</ns4:p><ns4:p>...
Abstract Background Walking cadence has been suggested as a measure of activity intensity; however, it remains uncertain if prefrail and frail older adults can increase their walking doing so leads to improvements in functional capacity. We aimed determine be increased this improvement capacity adults. Methods performed secondary data analysis intervention living retirement communities. Patients were randomized Casual Speed (CSW) High-Intensity (HIW) groups. Our primary outcome was 6-minute...
ABSTRACT To understand the genetic basis of complex traits, it is important to be able efficiently phenotype many genetically distinct individuals. In nematode Caenorhabditis elegans , individuals have been isolated from diverse populations around globe and whole-genome sequenced. As a result, hundreds wild strains with known genome sequences can used for genome-wide association studies (GWAS). However, phenotypic analysis these laborious, particularly quantitative traits requiring multiple...
Gunning, Samantha; La, Ashley; Hung, Anthony; Rubin, Daniel S.; Koyner, Jay L. Author Information