A5089978533- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Advanced Vision and Imaging
- Endometrial and Cervical Cancer Treatments
- RNA and protein synthesis mechanisms
- Oral health in cancer treatment
- Advanced Image Processing Techniques
- Ear and Head Tumors
- Insect-Plant Interactions and Control
- Prostate Cancer Treatment and Research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Prostate Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Machine Learning in Bioinformatics
- Lung Cancer Diagnosis and Treatment
- Video Coding and Compression Technologies
- Thyroid Cancer Diagnosis and Treatment
- Microscopic Colitis
- Cancer Immunotherapy and Biomarkers
- Video Surveillance and Tracking Methods
- Renal and related cancers
Icahn School of Medicine at Mount Sinai
2016-2025
University of California, San Francisco
2023-2025
Neurological Surgery
2023-2025
University of California, Berkeley
2024
Memorial Sloan Kettering Cancer Center
2023
Mount Sinai Health System
2021
Sunnybrook Research Institute
2021
Sunnybrook Hospital
2021
Kaiser Permanente Oakland Medical Center
2019-2021
Advanced Technologies Group (United States)
2020
Abstract T cell-based immunotherapies hold promise in treating cancer by leveraging the immune system’s recognition of cancer-specific antigens 1 . However, their efficacy is limited tumours with few somatic mutations and substantial intratumoural heterogeneity 2–4 Here we introduce a previously uncharacterized class tumour-wide public neoantigens originating from RNA splicing aberrations diverse types. We identified cell receptor clones capable recognizing targeting derived aberrant GNAS...
ABSTRACT Conifers are resistant to attack from a large number of potential herbivores or pathogens. Previous molecular and biochemical characterization selected conifer defence systems support model multigenic, constitutive induced defences that act on invading insects via physical, chemical, ecological (multitrophic) mechanisms. However, the genomic foundation complex resistance mechanisms conifers is largely unknown. As part genomics strategy characterize inducible possible against insect...
As part of a genomics strategy to characterize inducible defences against insect herbivory in poplar, we developed comprehensive suite functional resources including cDNA libraries, expressed sequence tags (ESTs) and microarray platform. These are designed complement the existing poplar genome (Populus spp.) ESTs by focusing on herbivore- elicitor-treated tissues incorporating normalization methods capture rare transcripts. From set 15 standard, normalized or full-length generated 139,007...
Abstract: Background : The success of osseointegrated implants ad modum Brånemark for single‐tooth restorations is documented. Future developments should aim at improving the benefits to patients by decreasing treatment time, minimizing surgical stages, and maximizing esthetic outcomes. Using knowledge from studies immediate implant placement, one‐stage, loading protocols, authors developed provisional. Purpose purpose this study was develop a protocol provide an solution restoring single...
High-risk histology including UPSC, CC, and high-grade (G3) endometrioid adenocarcinoma (EAC) have a worse prognosis compared to G1-2 EAC. It is unknown whether G3EAC outcomes are more similar UPSC/CC or The purpose of this study was compare overall survival (OS) among G1-3 EAC, for International Federation Gynecology Obstetrics stages I III.The National Cancer Data Base queried patients diagnosed with (1988 classification) Stage I-III EAC from 1998 2012 who underwent surgery as definitive...
Abstract Background The sequencing and analysis of ESTs is for now the only practical approach large-scale gene discovery annotation in conifers because their very large genomes are unlikely to be sequenced near future. Our objective was produce extensive collections cDNA clones support manufacture microarrays white spruce ( Picea glauca [Moench] Voss). Results We produced 16 libraries from different tissues a variety treatments, partially 50,000 clones. High quality 3' 5' reads were...
Wearable digital self-tracking technologies for monitoring individuals' health condition have become more accessible to the public in recent years with development of connected portable devices, such as smart phones, watches, bands, and other personal biometric devices. Mining behavioural patterns from wearable data along available sensory data, has potential offer an objective, insightful service clinical professionals healthcare. For example, accurate identification human activities could...
We present a novel compression algorithm for reducing the storage of LiDAR sensor data streams. Our model exploits spatio-temporal relationships across multiple sweeps to reduce bitrate both geometry and intensity values. Towards this goal, we propose conditional entropy that models probabilities octree symbols by considering coarse level previous sweeps' geometric information. then use learned probability encode full stream into compact one. experiments demonstrate our method significantly...
Abstract Background Accurate delineation of organs at risk (OARs) is crucial yet time‐consuming in the radiotherapy treatment planning workflow. Modern artificial intelligence (AI) technologies had made automation OAR contouring feasible. This report details a single institution's experience evaluating two commercial auto‐contouring software tools and making well‐informed decisions about their clinical adoption. Methods A cohort 36 patients previously treated our institution were selected...
Abstract Purpose: To investigate the relationship between spatial parotid dose and risk of xerostomia in patients undergoing head-and-neck cancer radiotherapy, using machine learning (ML) methods.
Methods: Prior to conducting voxel-based ML analysis dose, two steps were taken: 1) The was standardized through deformable image registration a reference patient; 2) Bilateral doses regrouped into contralateral ipsilateral portions depending on their proximity gross tumor target....
Abstract Background: High tumor heterogeneity and low mutational burden in cancers pose significant challenges for immunotherapy. To address this, we developed a novel silico pipeline to characterize cancer-specific splicing events (neojunctions; NJs) expressed ubiquitously across ten cancer types. This approach successfully identified tumor-wide, public, alternatively neoantigens (ASNs) that elicit CD8+ T-cell-mediated cytotoxicity multiple cancers. Methods: Our SSNIP recurring public NJs...
In this paper we tackle the problem of stereo image compression, and leverage fact that two images have overlapping fields view to further compress representations. Our approach leverages state-of-the-art single-image compression autoencoders enhances with novel parametric skip functions feed fully differentiable, disparity-warped features at all levels encoder/decoder second image. Moreover, model probabilistic dependence between codes using a conditional entropy model. experiments show an...
Thirteen cDNA libraries constructed from small amounts of leaf rust mRNA using optimized methods served as the source for generation 25 558 high-quality DNA sequence reads. Five life-cycle stages were sampled: resting urediniospores, urediniospores germinated over water or plant extract, compatible, interactive during appressorium haustorium formation just before sporulation, and an incompatible interaction. populations subjected to treatments such full-length production, subtractive...
Objectives/Hypothesis This study examined saliva weight over time and its association with diet patient‐rated swallowing, dry mouth, sticky saliva, dysgeusia quality of life in head neck cancer (HNCA) patients treated surgery plus adjuvant chemoradiotherapy (CRT), or primary CRT. Study Design Prospective cohort an outpatient HNCA center setting. Methods Patients were seen pretreatment, 1, 3, 6, 12, 24, 36 + months post‐treatment. All had newly diagnosed oral, oropharynx, nasopharynx,...
T-cell-mediated immunotherapies are limited by the extent to which cancer-specific antigens homogenously expressed throughout a tumor. We reasoned that recurrent splicing aberrations in cancer represent potential source of tumor-wide and public neoantigens, test this possibility, we developed novel pipeline for identifying neojunctions uniformly within tumor across diverse types. Our analyses revealed multiple recur patients either exhibited intratumor heterogeneity or, some cases, were...
AIMTo uncover the role of hepatocyte nuclear factor 4 alpha (HNF4α) in regulating hepatic expression microRNAs. METHODSMicroarray and real-time PCR were used to determine microRNAs young-adult mice lacking Hnf4α liver (Hnf4α -LivKO).Integrative genomics viewer software was analyze public chromatin immunoprecipitation-sequencing datasets for DNA-binding HNF4α, RNA polymerase-Ⅱ, histone modifications loci mouse human hepatoma cells.Dual-luciferase reporter assay conducted effects HNF4α on...